1-9 A-D E-G H-M N-P Q-S T-Z

PVP K 30 (POLYVINYLPYRROLIDONE)

PVP K 30

SYNONYMS:

pvpK 30; PVPK30; PVP, K, 30; pvp, k, 30; Polyvinylpyrrolidone; Poly, vinyl, pyrro, lidone; pvpk30; PVPK, 30; Poly(vinylpolypyrrolidone); Polyvinylpyrrolidone and Vinylpyrrolidone Co PVP K-30 (POLY VINYL PYRROLIDONE ) POLİ VİNİL PİROLİDON
CAS NO:9003-39-8
SYNONYMS :pvpK 30; PVPK30; PVP, K, 30; pvp, k, 30; Polyvinylpyrrolidone; Poly, vinyl, pyrro, lidone; pvpk30; PVPK, 30; Poly(vinylpolypyrrolidone); Polyvinylpyrrolidone and Vinylpyrrolidone Copolymers (PVP); Hydrophilic Polymers; Hydrophobic Polymers; Mat3 RP; 2-Pyrrolidinone, 1-ethenyl, homopolymer; 2- 3611; Crospovidone; Crospovidonum; Crospovidonum, [INN-Latin]; EPA Pesticide Chemical Code 079033; 1-vinylpyrrolidin-2-one homopolymer; Plasdone K29-32; Plasdone K29/32; Polyvinylpyrrolidone K 30; Polyvinylpyrrolidone K-29/32; Polyvinylpyrrolidone K30; Povidone K29-32; Povidone K29/32; PVP K-30; PVP K30; PVP-K 30; Ganex P 804; Ganex p-804; Hemodesis; Hemodez; HSDB 205; K 115 (polyamide); K 115 (VAN); K 15; K 25 (polymer); K 25 (VAN); K 30 (polymer); K 30 (VAN); K 60 (polymer); K 60 (VAN); K 90; Peviston; Plasdone; Plasdone 4; Plasdone K 29-32; Plasdone K-26/28; Plasdone No. 4; N-Vinyl-2-pyrrolidone polymer; N-Vinylbutyrolactam polymer; N-Vinylpyrrolidinone polymer; N-Vinylpyrrolidone polymer; Plasdone XL; Plasmosan; Polividona; Polividona [INN-Spanish]; Polividone; Polividone [DCIT]; Poly(1-(2-oxo-1-pyrrolidinyl)-1,2-ethanediyl), alpha-hydro-omega-((4-(iodo-(sup 131)I)phenyl)methyl)-; Poly(1-(2-oxo-1-pyrrolidinyl)ethylene); Poly(1-ethenyl-2-pyrrolidinone); Poly(1-vinyl-2-pyrrolidinone); Poly(1-vinyl-2-pyrrolidinone) homopolymer; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.1; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.2; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.3; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.4; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.5; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.6; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.7; Poly(1-vinyl-2-pyrrolidone); Poly(1-vinylpyrrolidinone); Poly(N-vinyl-2-pyrrolidinone); Poly(N-vinyl-2-pyrrolidone); Poly(N-vinylbutyrolactam); Poly(N-vinylpyrrolidinone); Poly(N-vinylpyrrolidone); Poly(vinylpyrrolidinone); Poly-N-vinyl pyrrolidone; Toxobin; UNII-2S780E561; UNII-333AG72FWJ; UNII-40UAA97IT9; UNII-68401960MK; UNII-6B46OH7T95; UNII-C67P1734QJ; UNII-E54VE15114; UNII-FZ989GH94E; UNII-H7AGY1OJO8; UNII-K0KQV10C35; UNII-RDH86HJV5Z; UNII-SZR7Z3Q2YH; UNII-U725QWY32X; Vinisil; Vinylpyrrolidinone polymer; Vinylpyrrolidone polymer; polivinilpirolidon; Poli (vinylpolypyrrolidone); Polivinilpirolidon ve Vinilpirolidon Kopolimerleri (PVP); Hidrofilik Polimerler; Hidrofobik Polimerler; Malzeme Bilimi; Poli (vinilpirolidinon) (PVP); Poli (vinilpirolidon); Poli (vinilpirolidon) (PVP) ve Kopolimerler; Polimer Bilimi, Polimerler, Vinilpiridin ve Vinipirrolidon Polimerler; Plasdone, PVP, Polyvidone, Povidone; 2-Pirolidinon, 1-etenil-, homopolimer (9003-39-8); PVP, Povidon; PVPP, Crospovidone, Polyvidone; PNVP; Poli [1- (2-okso-1-pirrolidinil) etilen]; 1-Etenil-2-pirolidon homopolimeri; 1-vinil-2-pirrolidinon-Polymere; K25; K60; POP; PVP; k115; pvp2; pvp3; pvp4; pvp5; pvp6; Kollidon 25; Vinylpirolidonun Homopolimeri; polivinilpirolidon; 1-Etenil-2-pirolidinon homopolimeri; 1-Etenil-2-pirolidinon polimerleri; 1-Etenil-2-pirolidinon, homopolimer; 1-Vinil-2-pirolidinon homopolimeri; 1-Vinil-2-pirolidinon polimer; 1-Vinil-2-pirolidon polimer; 143 RP; 2-Pirolidinon, 1-etenil, homopolimer; 2-Pirolidinon, 1-vinil-, polimerler; 2-Pirolidinon, 1-vinil-, polimerler, compd. alüminyum asetat ile; Ajan 717; alfa-Hidro-omega- (p-iyodobenzil) poli (1- (2-okso-1-pirolidinil) etilen) - (sup 131) I; alfa-Hidro-omega- (p-iyodobenzil) poli (1- (2-okso-1-pirolidinil) etilen) - (sup 131) I; (İyotun küçük bir kısmı, radyoaktif izotoptur, (sup 131) I); Antaron P 804; AT 717; Caswell No. 681; CCRIS 3611; Krospovidon; Crospovidonum; Crospovidonum, [INN-Latin]; EPA Pestisit Kimyasal Kodu 079033; 1-vinilpirolidin-2-on homopolimer; Plasdone K29-32; Plasdone K29 / 32; Polivinilpirolidon K 30; Polivinilpirolidon K-29/32; Polivinilpirolidon K30; Povidone K29-32; Povidone K29 / 32; PVP K-30; PVP K30; PVP-K30; Ganex P 804; Ganex p-804; Hemodesis; Hemodez; HSDB 205; K 115 (poliamid); K 115 (VAN); K 15; K25 (polimer); K25 (VAN); K30 (polimer); K30 (VAN); K60 (polimer); K 60 (VAN); K 90; Peviston; Plasdone; Plazdon 4; Plasdon K 29-32; Plasdon K-26/28; 4 No'lu Plasdone; N-Vinil-2-pirolidon polimer; N-Vinylbutyrolaktam polimer; N-Vinilpirrolidinon polimer; N-Vinilpirrolidon polimer; Plasdone XL; Plasmosan; Polividona; Polividona [INN-İspanyolca]; Polividone; Polividone [DCIT]; Poli (1- (2-okso-1-pirolidinil) -1,2-etandiil), alfa-hidro-omega - ((4- (iyodo- (sup 131) I) fenil) metil) -;
Poli (1- (2-okso-1-pirrolidinil) etilen); Poli (1-etenil-2-pirrolidinon); Poli (1-vinil-2-pirrolidinon); Poli (1-vinil-2-pirolidinon) homopolimeri; Poli (1-vinil-2-pirolidinon) Hueter Polimer No.1; Poli (1-vinil-2-pirolidinon) Hueper Polimer No.2; Poli (1-vinil-2-pirolidinon) Hueper Polimer No.3; Poli (1-vinil-2-pirolidinon) Kaliper Polimer No.4; Poli (1-vinil-2-pirolidinon) Daha Dayanıklı Polimer No.5; Poli (1-vinil-2-pirolidinon) Kaliper Polimer No.6; Poli (1-vinil-2-pirolidinon) Daha Dayanıklı Polimer No. 7; Poli (1-vinil-2-pirolidon); Poli (1-vinilpirolidinondur); Poli (N-vinil-2-pirrolidinon); Poli (N-vinil-2-pirolidon); Poli (N-Vinilbutirolaktam); Poli (N-vinilpirolidinondur); Poli (N-vinil pirolidon); Poli (vinilpirolidinondur); Poli-N-vinil pirolidon; Toxobin; LXVIII-2S780E561; LXVIII-333AG72FWJ; LXVIII-40UAA97IT9; LXVIII-68401960MK; LXVIII-6B46OH7T95; LXVIII-C67P1734QJ; LXVIII-E54VE15114; LXVIII-FZ989GH94E; LXVIII-H7AGY1OJO8; LXVIII-K0KQV10C35; LXVIII-RDH86HJV5Z; LXVIII-SZR7Z3Q2YH; LXVIII-U725QWY32X; Vinisil; Vinilpirrolidinon polimer; Vinilpirrolidon polimer; pvpK 30;

Technical Datasheet | Supplied by Ashland Specialty Chemical
PVP K-30 by Ashland Specialty Chemical is a hygroscopic, amorphous polyvinylpyrrolidone. Used in industrial, specialty and imaging coatings & paints and as a media component in digital ink jet-printing. Offers high polarity, dispersancy, hydrophilicity, adhesion, cohesivity and high glass transition temperature. PVP K-30 can be plasticized with water and most common organic plasticizers.
PVP K-30 100% Powder is soluble in water and many organic solvents and it forms hard, transparent, glossy film. Ashland's PVP is compatible with most inorganic salts and many resins. PVP stabilizes emulsions, dispersions and suspensions. While PVP is used as a film former in hair styling products, PVP can also be used as an emulsion stabilizer in creams and lotions and as a dispersant for hair colorants. Additionally, pharmaceutical grade PVP can be used in toothpastes and mouthwashes. PVP K-30 100% Powder appears as a white powder.
Polyvinylpyrrolidone (PVP K-30) pure

9003-39-8

HSN Code : 29420090
IMDG Identification : Not Regulated for Transport (Non-Haz)
Molecular Formula : (C6H9NO)x
Molecular Weight : ~40000
Storage : Room Temperature
Shelf Life : 60 Months

MSDS
Product Datasheet
Stock Check & Taxation Details
Enter Batch No. for COA

Online Certificate of Analysis
Polyvinylpyrrolidone (PVP K-30) pure

Specifications

Ürün Adı POLIVINIL PROLIDON - PVP K 30


Appearance (Colour) White to off - white
Appearance (Form) Crystalline powder
Solubility (Turbidity) 10% aq. solution Clear
Nitrogen content (N) 11.5 - 12.5%
pH (5% aq. solution) 3.0 - 7.0
Sulphated Ash max. 0.1%
Heavy Metals (Pb) max. 0.001%
K-value ~ 30
Vinyl pyrrolidone max. 0.8%
Water (KF) max. 5%
Chemical Name:Polyvinylpyrrolidone
Polyvinylpyrrolidone
Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone:[1]
Uses
Medical
PVP was used as a plasma volume expander for trauma victims after the 1950s.

It is used as a binder in many pharmaceutical tablets;[2] it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.[3] The long-term effects of crospovidone or povidone within the lung are unknown.)

PVP added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.[4] This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others.

It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.[5]

PVP is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Examples of this use include Bausch & Lomb's Ultra contact lenses with MoistureSeal Technology[6] and Air Optix contact lens packaging solution (as an ingredient called "copolymer 845").[7]

PVP is used as a lubricant in some eye drops, e.g. Bausch & Lomb's Soothe.[8]

Technical
PVP is also used in many technical applications:

as an adhesive in glue stick and hot-melt adhesives
as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process
as an emulsifier and disintegrant for solution polymerization
to increase resolution in photoresists for cathode ray tubes (CRT)[9]
in aqueous metal quenching
for production of membranes, such as dialysis and water purification filters
as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating
as a thickening agent in tooth whitening gels[10]
as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation
as an additive to Doro's RNA extraction buffer[citation needed]
as a liquid-phase dispersion enhancing agent in DOSY NMR [11]
as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly[12]
as a stabilizing agent in all inorganic solar cells[13]
Other uses
PVP binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers.

PVP is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions.[14][15] PVP is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some.

As a food additive, PVP is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers.

In molecular biology, PVP can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.

In microscopy, PVP is useful for making an aqueous mounting medium.[16]

PVP can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.[17]

Safety
The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses,[18] and it is generally considered safe. However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP has come in contact with autologous serum (internal blood fluids) and mucous membranes. For example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP component of the solution.[19] A woman, who had previously experienced urticaria (hives) from various hair products, later found to contain PVP, had an anaphylactic response after povidone-iodine solution was applied internally. She was found to be allergic to PVP.[20] In another case, a man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP.[21]

Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses, although testing results in some patients show no signs of allergy to the suspect chemical. Allergies attributed to these other chemicals may possibly be caused by the PVP instead.[22][23]

Properties
PVP is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol,[24] as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin).[25] When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings.

A 2014 study found fluorescent properties of PVP and its oxidized hydrolyzate.[26]

History
PVP was first synthesized by Walter Reppe and a patent was filed in 1939 for one of the derivatives of acetylene chemistry. PVP was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production.[27][28]


Product #
Description
PVP40 Polyvinylpyrrolidone, average mol wt 40,000,
PVP10 Polyvinylpyrrolidone, average mol wt 10,000,
PVP360 Polyvinylpyrrolidone, average mol wt 360,000,
81420 Polyvinylpyrrolidone, K 30,
437190 Polyvinylpyrrolidone, average Mw ~1,300,000 by LS,
81440 Polyvinylpyrrolidone, K 90,
P0930 Polyvinylpyrrolidone, powder, BioXtra, suitable for mouse embryo,
P2307 Polyvinylpyrrolidone, plant cell culture tested, average mol wt 10,000,
234257 Polyvinylpyrrolidone, powder, average Mw ~29,000,
856568 Polyvinylpyrrolidone, powder, average Mw ~55,000,
P5288 Polyvinylpyrrolidone, for molecular biology, nucleic acid hybridization tested, mol wt 360,000,
90268 Polyvinylpyrrolidone, K 25, tested according to Ph Eur,

 

Synonymsk25;k60;POP;PVP;k115;pvp2;pvp3;pvp4;pvp5;pvp6
CBNumber:CB4209342
Molecular Formula:CH4
Formula Weight:16.04246
PVP K-series
Chemistry: PVP polymers and VP derivatives
INCI: PVP
SDS Link >
Polyvinylpyrrolidone is a hygroscopic, amorphous polymer supplied as a white, free-flowing powder or a clear aqueous solution. Available in several molecular weight grades, they are characterized by K-value, and used in a great variety of applications. Polyvinylpyrrolidone can be plasticized with water and most common organic plasticizers. It is considered to be physiologically inert:

Applications take advantage of one or more properties inherent in the polymer, typically due to the lactam ring.
High polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts.
Dispersancy, where components in a mixture are uniformly distributed through the use of polyvinylpyrrolidone.
Hydrophilicity, where the substantial water solubility of polyvinylpyrrolidone is its dominant feature and frequently a factor along with other properties valuable to numerous applications.
Adhesion, taking advantage of the higher molecular weight polyvinylpyrrolidones formulating in aqueous media, then evaporating sufficient water to generate a solid product for the desired application.
Cohesivity, where cohesive strength is achieved through a variety of dry blending and granulation techniques.
Polyvinylpyrrolidone is cross-linkable to a water insoluble, swellable material either in the course of vinylpyrrolidone polymerization, by addition of an appropriate multifunctional comonomer or by post-reaction, typically through hydrogen abstraction chemistry.
POLİVİNİL PROLİDON (PVP)


Tanım

: Hafif karakteristik kokulu beyaz toz.

Ambalaj birimi

: 90 kg PE varil.

Cas No

: 9003-39-8

Kimyasal adı

: Vinilprolidonun homopolimerleri (polivinilprolidon).

Spesifikasyonlar

:

PVP K 30 Toz

 

 

 

Vinil prolidon

: < 2 mg/kg

Katı içerik

: 96,3 g/100 g

K değeri

: 30,0

pH değeri, %10 suda

: 3,4

Monomer ünitesi molekül ağırlığı: 111,14 g/mol

Sulu çözeltileri berrak ve renksiz-hafif sarımsı'dır. Toz ürünler, beyazdır.

Çözünürlük: Suda,etanol ve izopropanolde çözünür. Elektrolitik karaktere sahip değildir. Sulu çözeltileri, farklı suda çözünen selüloz türevlerinin çözletileriyle karıştırılabilir. Onlar genelde kullanılan non-iyonik, anyonik veya katyonik ürünlerle ve poliakrilatlar, poliquatlar, tuzlar, asitler ve bazlarla kombine edilebilirler. PVP K çeşitleri, nispeten yüksek miktarda tuz eklenmesiyle çözeltilerden çöktürülebilir. PVP K 90, K 17'den hissedilir derecede daha fazla çökme gösterir. PVP'nin farklı organik solventlerdeki çözünürlüğü geniş bir alanda farklılık gösterir. PVP K çeşitleri en az % 10 PVP içeren çözeltiler verecek şekilde aşağıdaki solventlerde çözünürler:

Alkoller: Etanol, n-propanol,izopropanol, n-butanol, 2-etil-1-hekzanol, siklohekzanol, metilsiklohekzanol, propilen glikol, 1,3-butandiol, metilizobutil karbinol, gliserol.

Esterler: etil laktat

Eter Alkolleri: Hekzaetilen glikol, dietilenglikol, monometil eter, polietilen glikol 400, etilenglikol monoetil eter, dietilen glikol, trietilenglikol

Ketonlar: siklohekzanon (ısıtarak) metil siklo hekzanon,

Asitler: Formik asit, asetik asit, propiyonik asit

Aminler: sikloheksilamin, dietanolamin, trietanol amin, etilendiamin, monoetanol amin

Depolama: 6'nın üzerindeki pH ‘a sahip sulu çözeltilerin viskositesi, artan sıcaklık ve uzayan depolama sırasında artar. %30'un altındaki konsantrasyonlardaki asitleştirilmiş çözeltiler, depolama sırasında küf gelişimine eğilim gösterirler.Bu polihekzametilen biguadin HCl gibi bir koruyucu eklenerek önlenebilir. OH veya NH2 gruplarıyla reaksiyon veren koruyucularun kullanımı önerilmez.

PVP K 80'in K değeri istisnai olarak uzun depolama sırasında düşer.

Depolama ve kararlılık: PVP K 17,30,80 ve 90 çözeltileri 25 oC'nin altında açılmamış orijinal ambalajında en az 3 yıl raf ömrüne sahiptir. PVP K 30, 80, 85Q ve K90 çözeltileri 20 oC'nin altında tercihen 4 oC'de açılmamış orijinal ambalajında en az 2 yıl raf ömrüne sahiptir.

Uygulamalar ve teknik özellikler: Kozmetikte çeşitli uygulamalar için kullanılır. Kalınlaştırıcı ajanlar, emülsifiyerler, yağlayıcı ve bağlayıcılar olarak kozmetikte kullanılırlar. Temizleyici, boya veya cilt ve saç görünümünü yükselten kozmetik ürünlerine eklenmesi uygundur. PVP K 30 toz ve PVP K 90 toz yağlı ve yağsız bazlı belirli kremlerin her ikisininde formülasyonlarında kulllanılabilir. PVP K 30 saç şekillendirici preparatlarda sertleştirici ajan olarak rol oynar ve şampuanların, saç boyası ve benzeri preparatların kıvamını ayarlar. PVP K 30 toz, cildi korumak amacıyla şampuan ve ev deterjanlarına eklenebilir. Anyonik kolloidlerin tersine, PVP K 30 toz'un boyaları bağlama eğiliminde olduğu hesaba katılması gerekmesine rağmen, PVP K çeşitleri örn;bazik boyalar ve katyonik maddelerle birleştirilebilirler. PVP K 30 Toz, şekillendirici jeller ve çözeltiler gibi saç bakım preparatlarında kullanılabilir.

Teknik uygulamaların özeti: Süspansiyonlar, dağıtıcılar ve emülsiyonlar: Sulu süspansiyon, emülsiyon ve dağılımlar PVP K ürünleri eklenerek kararlı hale getirilebilir. Onlar, kendilerinin koagüle olmasını engelleyen koloid partiküllerin yüzeyinde ince bir tabaka olarak emilirler.

Plastik üretimleri: Katı plastik polimerlerin üretiminde , PVP K ürünleri koruyucu kolloidler ve polimerizasyon stabilize edicileri olarak kullanılırlar.

Yapıştırıcılar: K 90 ve K 80, sodyum stearat bazlı yapıştırıcı stiklerde kalınlaştırıcı ve yapıştırıcı olarak kullanılabilirler. Farklı PVP K ürünleri, istenen yoğunlukta yapıştırıcı stikleri vermesi amacıyla harmanlanabilir. Yapıştırıcı dağılımlarda PVP K ürünleri, koruyucu kolloidler ve kalınlaştırıcı ajanlar olarak kullanılırlar. PVP K ürünleri suda kolayca çözünebildiği gibi, posta pulları, zarflar vs... için ıslatıcı reçinelerde kullanılabilir.

Boyalar: K 30 ve K 90 emülsiyon boyalar ve dispersiyon kaplamalarında koruyucu kolloidler ve dağıtıcı olarak kullanılırlar ve dağılımların reolojisini etkilerler.

Kağıt yapımı: Suda hızlı çözünmesi nedeniyle kağıt kaplamada kullanılırlar. (eğer bir sonraki adımda kağıdı tekrar ıslatmak tasarlanmıyorsa).Kağıdı kıvrılmaktan alıkoyar ve pürüzsüz, düzgün bir yüzey sağlar.

Çamaşır deterjanları: Bir katkı olarak, yıkama sıvılarının kir (leke) kapasitesini artırır. Ve boyaların tekrar tortu bırakmasını engeller. Enzimlerin üretiminde tozu bastırmak için, enzimler için bir kaplayıcı olarak kullanılabilirler.

Cam elyafı: K 90 elyafın yüzeyini düzeltmek için haşıl preparatlarında bir komponent olarak kullanılırlar.

Baskı ve diğer mürekkepler: İstenen viskositeyi elde etmek için kullanılabilir.

Seramikler: K 90, kolay işlenemeyen killer için bir bağlayıcı olarak kullanılabilir. Diğer bağlayıcılara göre avantajı, ateşleme sırasında tamamen yanmaya devam etmesi ve bu nedenle seramik kütlesini etkilememesi. Bu özellikle Na iyonlarını içermeyen elektriksel yalıtkanların üretiminde önemlidir. PVP K 90, ayrıca yanmaz pervazların gücünü artırır.

Tabletleme yardımcıları: PVP K 30, ilaca ait olmayan (dişçiliğe ait temizleme tabletleri veya boya ve boya kutularının tabletleri gibi) amaçlar için kullanılan tabletlerin tamamı için bir bağlayıcı olarak kullanılır.

Fotoğraf filmleri: PVP K 30, koruyucu kolloid ve yapışma tetikçisi olarak fotoğraf filmlerinin üretiminde kullanılabilir. K 17, fotoğraf kağıdında bir bağlayıcı olarak kullanılır.

Böcek ilaçlarında: K 90, böcek ilacı dağılımlarında bir dağıtıcı olarak kullanılır ve aktif maddenin bitkiye yapışmasını iyileştirir.

Yapıştırıcı bandajların hazırlanması: K 30 ve K 90 kullanımı kolay plaster bandajları için bir bağlayıcı olarak kullanılabilir. Bandaja, PVP K 30 ve K 90 ilavesi içeren bir metanoik süspansiyon olarak uygulanır ve sonradan kurutulur.

Not: İlaç preparatlarında kullanıma uygun değildir.

Ek bilgi: Film yapıcı ve kalınlaştırıcı olarak kullanılır.Farklı molekül ağırlıklı vinil prolidon homopolimerleridir. Moleküler ağırlık PVP nin setting özelliklerini belirler. Moleküler ağırlık ne kadar yüksekse, setting'de o kadar büyük olur. Jel tipi uyuglamalarda Carbomer tipi kalınlaştırıcı ve diğer karşıt bağlı poliakrilatlarla uyumludur. Bitmiş ürünlerde yüksek saflık istenen su bazlı uygulamalarda kullanım için idealdir.Özellikle ıslak görünüm jelleri saç kremleri, pompalı spreyler ve sıvı saç şekillendirme (setting) preparatlarında normalden-sert'e kadar bir tutuş sağlar. PVP K 30 Toz, saç bakımı ürünleri (şekillendirme jel ve solüsyonlar gibi) üretiminde kullanılabilir. Saç jeli formülasyonunun yanı sıra, PVP K 30 düşük viskositenin önem taşıdığı pompalı spreylerde kullanılır. K 80 ve K 90 saç jelleri ve kremleri gibi yüksek tutuşlu ve yüksek viskositeli ürünler içindir.

Polyvinylpyrrolidone K 30
Molecular Formula: (-CH(NCH2CH2CH2CO)CH2
-)n
Molecular Weight: 35,000-51,000
CAS # : 9003-39-8
Synonym: PVP
Physical Description: White to off white powder
Solubility: Soluble in water (> 100 mg/ml), methanol, ethanol, alcohol, chloroform and glycerol, acetic acid; insoluble in dimethyl ether,
ethyl acetate, acetone, toluene, xylene, mineral oil, carbon tetrachloride. If the pH value of the solutions is higher than 6, the viscosity
will increase slightly on storage, particularly at elevated temperatures; if the pH value is less than 7 and the concentration is lower than
30%, the solutions tend to become moldy during storage.1 The addition of a preservative can prevent mold and fungus growth during
storage. Addition of large quantities of salts will precipitate the PVP from solution.
Molecular Weight 10 K 30 K 40 K 360 K
K value*: 12-18 27-33 28-32 90-103
Synonym: PVP K 15 PVP K 30 PVP K 30 PVP K 90
Bulk Density (lb/cu ft) 36 29 20 --
*K values are derived from viscosity measurements and are calculated according to Fikentscher's formula.
Description: Typically used as thickeners, dispersing agents, detoxicant, complexing agent, lubricants and binders.
Availability:
Catalog Number Description Size
196056 Polyvinylpyrrolidone, average MW 10000;
typically used as a cryoprotectant and in
plant cell cultures.
100 g
500 g
102786 Polyvinylpyrrolidone, average MW 30000 100 g
500 g
1 kg
5 kg
195451 Polyvinylpyrrolidone, average MW 40000 100 g
500 g
1 kg
102787 Polyvinylpyrrolidone, average MW 360000 100 g
500 g
1 kg
5 kg
194017 Polyvinylpyrrolidone, average MW 360000,
molecular biology reagent; typically used in
nucleic acid hybridizations.
Povidone
Povidones are available in different molecular weights. The higher the molecular weight, the greater the viscosity and consequently the adhesive strength. The K-value denotes the intrinsic viscosity of the polymer related to the molecular weight, and is derived from the relative viscosity of the aqueous solution measured at 25°C. The direct correlation between the molecular weight and properties enables the appropriate grade to be used in each formulation in the appropriate concentration in order to achieve the optimum effect.

 

In order to provide formulators with flexibility in the choice of wet granulation binders with good adhesive strength and ease of handing, JRS PHARMA offers 2 grades of wet binders: VIVAPHARM® PVP K30 and VIVAPHARM® PVP K25.

 

Grade
Diclofenac sodium is a non-steroidal anti-inflammatory agent with a short biological half-life (1-2 hr) and requires multiple dosing. This research was carried out to develop and optimize diclofenac sodium loaded alginate-PVP K 30 microbeads to eliminate the need for multiple dosing and adverse effects.

Methods
Diclofenac sodium loaded alginate-PVP K 30 microbeads were prepared by ionotropic gelation. Particle size, drug release, swelling, FTIR and SEM analyses were performed.

Results
Optimized microbeads showed particle size of 0.589±0.054 to 0.620±0.067 mm, and drug entrapment efficiency of 97.88±2.86 to 98.60±3.55%. The in vitro drug release from microbeads was sustained over 10 hrs and followed controlled-release pattern. FTIR analysis indicated the possibility of intermolecular hydrogen bonding interactions, i.e., -OH...O=C in microbeads.

Conclusion
Microbeads for oral controlled delivery of diclofenac sodium were successfully developed by ionotropic gelation.
Alginate, the monovalent form of alginic acid, belong to the family of linear copolymers composed of ß-D- mannuronic acid monomers (M), regions of ?-L- guluronic acid residues (G), and regions of interspersed M and G units (1). It is used as matrix material in various formulations due to its hydrogel-forming properties (2). Alginates undergo gelation due to ionic interaction between carboxylic acid groups located on polymer backbone and these cations like Ca2+, Al3+, etc (3, 4). Various drugs have been successfully incorporated in alginate hydrogels and have exhibited different drug release profiles (1, 4-6).

Diclofenac sodium (DS) is a non-steroidal anti-inflammatory agent widely used as analgesic (7). Its biological half-life is 1-2 hr (2) and requires multiple dosing to maintain therapeutic concentration in blood. Hence, the controlled release systems of DS can eliminate the need for multiple dosing and adverse effects. Several investigations on formulation of DS-loaded alginate-based microparticles/beads using different polymer-blend have been reported (7-10). However, no attempt has been taken to formulate DS-loaded bead system using alginate-polyvinyl pyrrolidone (PVP) blend. Therefore in the present investigation, an attempt was made to develope and optimize DS-loaded alginate-PVP K 30 microbeads. The effects of ratios of sodium alginate to PVP K 30 and CaCl2 (cross-linker) concentrations on drug entrapment and release were analyzed using central composite design (CCD).

Go to:
MATERIAL AND METHODS
Materials
DS (Techno Remedies, India), calcium chloride, sodium alginate and PVP K 30 (Loba Chemie, India) were used in this study. Other chemicals used were of analytical grades.

Microbead preparation
DS-loaded alginate-PVP K 30 microbeads were prepared by ionotropic gelation (2). Sodium alginate and PVP K 30 aqueous solutions were mixed together. Then, DS was added to the mixture and homogenized (for 10 min, 1000 rpm). The resulting mixture (drug : polymer=1:2) was dropped into CaCl2 solution via 26-gauge needle. After 15 min, beads were collected by decantation, washed repeatedly with deionized water and dried at 45°C for 12 hrs.

DS-loaded alginate microbeads were prepared by the same method but without addition of PVP K 30.

Experimental design
The experimental factors were selected as polymer-blend ratio and CaCl2 concentration; while responses were Drug Entrapment Efficiency (DEE) and drug release after 10 hrs (R10hr). The factors and levels are reported in table 1. The quadratic model was used to evaluate responses using Design-Expert® Software according to CCD (11):
Used as binders in tablets, capsules & granules, stabilizers in oral suspensions, film formers, dispersants for pigments, thickeners and bioavailability improver.

Paracetamol tablets were prepared by wet granulation method using PVP K30, PVP K90 and mixture of PVP K30 and PVP K90 as binding agents. The effect of binding agents on the physical characteristics i.e. granule size, bulk density and angle of repose of the paracetamol granules were studied. The analysis of active constituents was followed by the study of weight variation, hardness, disintegration time, friability and dissolution test of all tablet formulations. All formulations comply with the weight variation test. Hardness of the tablets was significantly (p < 0.05) increased with increasing the concentration of the binders. Tablets prepared using only PVP K30 (2%) failed the friability test. The maximum disintegration time was 135 seconds and all tablets passed the dissolution test. A good correlation between various physical parameters of granules and tablets was observed. The PVP K90 showed better binding properties compared to the PVP K30 or mixture of PVP K90 and PVP K30.


Polyvinyl pyrrolidone is used as a powder and solution in the production of pharmaceutical tablets because of its adhesion properties.
This product is completely compatible and does not interact to other tablet components.
Since PVP K30 quickly forms a clear solution, it is suitable for producing high-solubility tablets. This product can be used as a solubility enhancer in polar solvents for topical and oral applications.
In addition, PVP K30 also plays an important role in emulsion stability and anti-sedimentation.
Polyvinyl pyrrolidone, due to its chemical structure (the presence of a lactam ring), can form a complex with many molecules containing functional groups such as hydroxyl, carboxylic and amine.
Applications:
• As a binder in a variety of oral tablets.
• Film forming in coated tablets.
• Contribute to the uniform distribution of pigment, stabilization and preservation of the composition of the percentage of pigments in the coating
• Stabilization of suspensions.
It finds use in detergents as an anti-redeposition agent(especially on carbonaceous soil) and as an anti-dyetransfer agent, where it complexes and solubilizes vagrant
dyes keeping clothes more color-pure.


• Essential or auxiliary material in a variety of liquid, glue stick and wound adhesives
• Production of various types of membranes for various applications such as dialysis, water specialization ...
• Containing film in seed veneers to create antimicrobial coating or seed protection and ...
• Color stabilizer and leveling agent for dyeing of all kinds of polyester, woolen and ...
• Anti- crystallization in syrups
• Stabilizing enzymes and thermally sensitive agents
Polyvinylpyrrolidone K 30
extra pure
Molecularbiology
PVP, Polyvidone, Povidon

Empirical formula (C6H9NO)n
Molar mass (M) ca. 40000 g/mol
WGK 1
CAS No.[9003-39-8]
Polyvinylpyrrolidone K 30
em number: 4607
Polyvinylpyrrolidone K 30
extra pure
CAS No.: 9003-39-8 print date: 24.11.2017
formula: (C6H9NO)n
density:
molcular weight: ~40000 g/mol
Type analysis
Appearance white to off-white powder
K-value 27,0-32,4
Nitrogen content (N) 11,5-12,8 %
Clearness (5 % in H2O) clear
Water (KF) ?5,0 %
Sulphated ash ?0,1 %
pH-value (5 % in H2O) 3,0-5,0
Vinylpyrrolidone (HPLC) ?0,001 %
Heavy metals ?0,001 %
Aldehyde ?0,05 %
Hydrazine ?0,0001 %
Peroxides (as H2O2) ?0,04 %

SECTION 1: Identification of the substance/mixture and of the
company/undertaking
1.1 Product identifier
Identification of the substance Polyvinylpyrrolidone
Article number 4607
Registration number (REACH) This information is not available.
EC number none
CAS number 9003-39-8
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses: laboratory chemical
laboratory and analytical use
1.3 Details of the supplier of the safety data sheet
Carl Roth GmbH + Co KG
Schoemperlenstr. 3-5
D-76185 Karlsruhe
Germany
Telephone: +49 (0) 721 - 56 06 0
Telefax: +49 (0) 721 - 56 06 149
e-mail: sicherheit@carlroth.de
Website: www.carlroth.de
Competent person responsible for the safety data
sheet
: Department Health, Safety and Environment
e-mail (competent person) : sicherheit@carlroth.de
1.4 Emergency telephone number
Emergency information service Poison Centre Munich: +49/(0)89 19240
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
Classification acc. to GHS
Classification acc. to GHS
Section Hazard class Hazard class and category
Hazard
statement
3.1O acute toxicity (oral) (Acute Tox. 5) H303
2.2 Label elements
Labelling GHS
Signal word Warning
Safety data sheet
Safe Work Australia - Code of Practice
Polyvinylpyrrolidone K 30 extra pure
article number: 4607
Version: GHS 2.0 en
Replaces version of: 2018-02-07
Version: (GHS 1)
date of compilation: 2018-02-07
Revision: 2018-04-24
Australia (en) Page 1 / 11
Hazard statements
H303 May be harmful if swallowed
Precautionary statements
Precautionary statements - response
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
Labelling of packages where the contents do not exceed 125 ml
Signal word: Warning
H303 May be harmful if swallowed.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
2.3 Other hazards
There is no additional information.
SECTION 3: Composition/information on ingredients
3.1 Substances
Name of substance Polyvinylpyrrolidone
CAS number 9003-39-8
Molecular formula (C6H9NO)n
Molar mass ~40,000 g
/mol
SECTION 4: First aid measures
4.1 Description of first aid measures
General notes
Take off contaminated clothing.
Following inhalation
Provide fresh air. In all cases of doubt, or when symptoms persist, seek medical advice.
Following skin contact
Rinse skin with water/shower. In all cases of doubt, or when symptoms persist, seek medical advice.
Following eye contact
Rinse cautiously with water for several minutes. In all cases of doubt, or when symptoms persist, seek
medical advice.
Following ingestion
Rinse mouth. Call a doctor if you feel unwell.
4.2 Most important symptoms and effects, both acute and delayed
Symptoms and effects are not known to date
4.3 Indication of any immediate medical attention and special treatment needed
none
Safety data sheet
Safe Work Australia - Code of Practice
Polyvinylpyrrolidone K 30 extra pure
article number: 4607
Australia (en) Page 2 / 11
SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Co-ordinate fire-fighting measures to the fire surroundings
water spray, foam, dry extinguishing powder, carbon dioxide (CO2)
Unsuitable extinguishing media
water jet
5.2 Special hazards arising from the substance or mixture
Combustible.
Hazardous combustion products
In case of fire may be liberated: nitrogen oxides (NOx), carbon monoxide (CO), carbon dioxide (CO2)
5.3 Advice for firefighters
Fight fire with normal precautions from a reasonable distance. Wear self-contained breathing apparatus.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
For non-emergency personnel
Wearing of suitable protective equipment (including personal protective equipment referred to under Section 8 of the safety data sheet) to prevent any contamination of skin, eyes and personal clothing. Do not breathe dust. Do not breathe dust. Avoid contact with skin, eyes and clothes.
6.2 Environmental precautions
Keep away from drains, surface and ground water.
6.3 Methods and material for containment and cleaning up
Advices on how to contain a spill
Covering of drains.
Advices on how to clean up a spill
Take up mechanically. Control of dust.
Other information relating to spills and releases
Place in appropriate containers for disposal. Ventilate affected area.
6.4 Reference to other sections
Hazardous combustion products: see section 5. Personal protective equipment: see section 8. Incompatible materials: see section 10. Disposal considerations: see section 13.
Safety data sheet
Safe Work Australia - Code of Practice
Polyvinylpyrrolidone K 30 extra pure
article number: 4607
Australia (en) Page 3 / 11
SECTION 7: Handling and storage
7.1 Precautions for safe handling
Avoid dust formation.
• Measures to prevent fire as well as aerosol and dust generation
Removal of dust deposits.
Advice on general occupational hygiene
Wash hands before breaks and after work.
7.2 Conditions for safe storage, including any incompatibilities
Keep container tightly closed. Store in a dry place.
Incompatible substances or mixtures
Observe hints for combined storage.
Consideration of other advice
• Ventilation requirements
Use local and general ventilation.
• Specific designs for storage rooms or vessels
Recommended storage temperature: 15?-?25 °C.
7.3 Specific end use(s)
No information available.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
National limit values
Occupational exposure limit values (Workplace Exposure Limits)
Data are not available.
8.2 Exposure controls
Individual protection measures (personal protective equipment)
Eye/face protection
Use safety goggle with side protection.
Skin protection
• hand protection
Wear suitable gloves. Chemical protection gloves are suitable, which are tested according to EN 374.
For special purposes, it is recommended to check the resistance to chemicals of the protective gloves
mentioned above together with the supplier of these gloves.
• type of material
Safety data sheet
Safe Work Australia - Code of Practice
Polyvinylpyrrolidone K 30 extra pure
article number: 4607
Australia (en) Page 4 / 11
NBR (Nitrile rubber)
• material thickness
>0,11 mm
• breakthrough times of the glove material
>480 minutes (permeation: level 6)
• other protection measures
Take recovery periods for skin regeneration. Preventive skin protection (barrier creams/ointments) is
recommended.
Respiratory protection
Respiratory protection necessary at: Dust formation. Particulate filter device (EN 143).
Environmental exposure controls
Keep away from drains, surface and ground water.
SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
Appearance
Physical state solid (powder)
Colour white - light beige
Odour faintly perceptible
Odour threshold No data available
Other physical and chemical parameters
pH (value) 3?-?5 (50 g
/l
, 20 °C)
Melting point/freezing point 130 °C
Initial boiling point and boiling range This information is not available.
Flash point not applicable
Evaporation rate no data available
Flammability (solid, gas) These information are not available
Explosive limits
• lower explosion limit (LEL) (25 g/m³)
• upper explosion limit (UEL) this information is not available
Explosion limits of dust clouds these information are not available
• lower explosion limit (LEL) 25 g/m³
Vapour pressure This information is not available.
Density 1.2 g
/cm³ at 20 °C
Vapour density This information is not available.
Safety data sheet
Safe Work Australia - Code of Practice
Polyvinylpyrrolidone K 30 extra pure
article number: 4607
Australia (en) Page 5 / 11
Relative density Information on this property is not available.
Solubility(ies)
Water solubility soluble
Partition coefficient
n-octanol/water (log KOW) This information is not available.
Auto-ignition temperature >400 °C
Decomposition temperature >130 °C
Viscosity not relevant (solid matter)
Explosive properties Shall not be classified as explosive
Oxidising properties none
9.2 Other information
There is no additional information.
SECTION 10: Stability and reactivity
10.1 Reactivity
Dust explosibility.
10.2 Chemical stability
Hygroscopic solid.
10.3 Possibility of hazardous reactions
Electrospraying technique has been successfully used to synthesize composite submicron particles of polyvinylpyrrolidone (PVP) and green tea extract (GTE). The precursor solutions were PVP in ethanol (15 wt%) and GTE in ethanol (10 wt%), which were then mixed at varying ratio. The mixed solution then underwent electrospraying process at an applied voltage of 15 kV, a distance of collector to the nozzle at 15 cm, and a flow rate of 3 µL/min. The composite submicron particles of PVP-GTE showed smooth and fine spherical morphology without fibers or beaded fibers. To a certain degree, the increase of GTE content in the PVP-GTE mixed solution decreased the average diameter of PVP-GTE composite particles. Moreover, the analysis of the FTIR spectra confirmed the existing molecular interaction between PVP and GTE in the composite submicron particles as shown by the shift of PVP wavenumber towards GTE, which has typically smaller wavenumber.

Preparation and characterization of solid dispersion freeze-dried efavirenz - polyvinylpyrrolidone K-30.

PubMed

Fitriani, Lili; Haqi, Alianshar; Zaini, Erizal

2016-01-01

The aim of this research is to prepare and characterize solid dispersion of efavirenz - polyvinylpyrrolidone (PVP) K-30 by freeze drying to increase its solubility. Solid dispersion of efavirenz - PVP K-30 was prepared by solvent evaporation method with ratio 2:1, 1:1, and 1:2 and dried using a freeze dryer. Characterizations were done by scanning electron microscopy (SEM), powder X-ray diffraction analysis, differential thermal analysis (DTA), and Fourier transform infrared (FT-IR) spectroscopy. Solubility test was carried out in CO2-free distilled water, and efavirenz assay was conducted using high-performance liquid chromatography with acetonitrile:acetic acid (80:20) as the mobile phases. Powder X-ray diffractogram showed a decrease in the peak intensity, which indicated the crystalline altered to amorphous phase. DTA thermal analysis showed a decrease in the melting point of the solid dispersion compared to intact efavirenz. SEM results indicated the changes in the morphology of the crystal into an amorphous form compared to pure components. FT-IR spectroscopy analysis showed a shift wavenumber of the spectrum efavirenz and PVP K-30. The solubility of solid dispersion at ratio 2:1, 1:1, and 1:2 was 6.777 μg/mL, 6.936 μg/mL, and 14,672 μg/mL, respectively, whereas the solubility of intact efavirenz was 0.250 μg/mL. In conclusion, the solubility of solid dispersion increased significantly (P < 0.05).

Polyvinylpyrrolidone (PVP)-assisted solvothermal synthesis of flower-like SrCO{sub 3}:Tb{sup 3+} phosphors

SciTech Connect

Xue, Yannan; Ren, Xiaolei; Zhai, Xuefeng

Graphical abstract: A simple solvothermal method for the synthesis of flower-like SrCO{sub 3}:Tb{sup 3+} phosphors with the assistance of polyvinylpyrrolidone (PVP, K30). Highlights: Black-Right-Pointing-Pointer Well-crystallized flower-like SrCO{sub 3}:Tb{sup 3+} phosphors could be easily prepared by a simple solvothermal method with the assistance of polyvinylpyrrolidone (PVP). Black-Right-Pointing-Pointer The amount of PVP and the reaction time have a strong effect on controlling the morphology and optical properties of SrCO{sub 3}:Tb{sup 3+} particles. Black-Right-Pointing-Pointer The main synthesizing process and the growth mechanism for the formation of final samples were proposed. -- Abstract: Well-crystallized flower-like SrCO{sub 3}:Tb{sup 3+} phosphors have been synthesized by anmore » inexpensive and friendly solvothermal process using polyvinylpyrrolidone (PVP, K30) as an additive without further annealing treatment. X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FT-IR), and field emission scanning electron microscopy (FESEM) as well as photoluminescence spectroscopy (PL) were used to characterize the resulting samples. The amount of PVP and the reaction time have strong effect on the morphology of the SrCO{sub 3}:Tb{sup 3+} particles. The results of XRD confirm the formation of a well-crystallized SrCO{sub 3} phase with an orthorhombic structure. The possible formation mechanism for flower-like SrCO{sub 3}:Tb{sup 3+} phosphor is proposed. The SrCO{sub 3}:Tb{sup 3+} phosphors show the characteristic {sup 5}D{sub 4}-{sup 7}F{sub J} (J = 6, 5, 4, 3) emission lines with green emission {sup 5}D{sub 4}-{sup 7}F{sub 5} (544 nm) as the most prominent group under ultraviolet excitation.« less

Electrospun polyvinylpyrrolidone (PVP)/green tea extract composite nanofiber mats and their antioxidant activities

NASA Astrophysics Data System (ADS)

Pusporini, Pusporini; Edikresnha, Dhewa; Sriyanti, Ida; Suciati, Tri; Miftahul Munir, Muhammad; Khairurrijal, Khairurrijal

2018-05-01

Electrospinning was employed to make PVP (polyvinylpyrrolidone)/GTE (green tea extract) composite nanofiber mats. The electrospun PVP nanofiber mat as well as the PVP/GTE nanofiber mats were uniform. The average fiber diameter of PVP/GTE composite nanofiber mat decreased with increasing the GTE weight fraction (or decreasing the PVP weight fraction) in the PVP/GTE solution because the PVP/GTE solution concentration decreased. Then, the broad FTIR peak representing the stretching vibrations of Oâ€"H in hydroxyl groups of phenols and the stretching of Nâ€"H in amine groups of the GTE paste shifted to higher wavenumbers in the PVP/GTE composite nanofiber mats. These peak shifts implied that PVP and catechins of GTE in the PVP/GTE composite nanofiber mats had intermolecular interactions via hydrogen bonds between carbonyl groups of PVP and hydroxyl groups of catechins in GTE. Lastly, the antioxidant activity of the PVP/GTE composite nanofiber mat increased with reducing the average fiber diameter because the amount of catechins in the composite nanofiber mat increased with the increase of surface area due to the reduction of the average fiber diameter.

Biomimetic Branched Hollow Fibers Templated by Self-assembled Fibrous Polyvinylpyrrolidone (PVP) Structures in Aqueous Solution

PubMed Central

Qiu, Penghe; Mao, Chuanbin

2010-01-01

Branched hollow fibers are common in nature, but to form artificial fibers with a similar branched hollow structure is still a challenge. We discovered that polyvinylpyrrolidone (PVP) could self-assemble into branched hollow fibers in an aqueous solution after aging the PVP solution for about two weeks. Based on this finding, we demonstrated two approaches by which the self-assembly of PVP into branched hollow fibers could be exploited to template the formation of branched hollow inorganic fibers. First, inorganic material such as silica with high affinity against the PVP could be deposited on the surface of the branched hollow PVP fibers to form branched hollow silica fibers. To extend the application of PVP self-assembly in templating the formation of hollow branched fibers, we then adopted a second approach where the PVP molecules bound to inorganic nanoparticles (using gold nanoparticles as a model) co-self-assemble with the free PVP molecules in an aqueous solution, resulting in the formation of the branched hollow fibers with the nanoparticles embedded in the PVP matrix constituting the walls of the fibers. Heating the resultant fibers above the glass transition temperature of PVP led to the formation of branched hollow gold fibers. Our work suggests that the self-assembly of the PVP molecules in the solution can serve as a general method for directing the formation of branched hollow inorganic fibers. The branched hollow fibers may find potential applications in microfluidics, artificial blood vessel generation, and tissue engineering. PMID:20158250

New metastable form of glibenclamide prepared by redispersion from ternary solid dispersions containing polyvinylpyrrolidone-K30 and sodium lauryl sulfate.

PubMed

Thongnopkoon, Thanu; Puttipipatkhachorn, Satit

2016-01-01

Modification of polymorphic forms of poorly water-soluble drugs is one way to achieve the desirable properties. In this study, glibenclamide (GBM) particles with different polymorphic forms, including a new metastable form, were obtained from redispersion of ternary solid dispersion systems. The ternary solid dispersion systems, consisting of GBM, polyvinylpyrrolidone-K30 (PVP-K30) and sodium lauryl sulfate (SLS), were prepared by solvent evaporation method and subsequently redispersed in deionized water. The precipitated drug particles were then collected at a given time period. The drug particles with different polymorphic forms could be achieved depending on the polymer/surfactant ratio. Amorphous drug nanoparticles could be obtained by using a high polymer/surfactant ratio, whereas two different crystalline forms were obtained from the systems containing low polymer/surfactant ratios. Interestingly, a new metastable form IV of GBM with improved dissolution behavior could be obtained from the system of GBM:PVP-K30:SLS with the weight ratio of 2:2:4. This new polymorphic form IV of GBM was confirmed by differential scanning calorimetry (DSC), Fourier transform infrared (FT-IR) spectroscopy, powder X-ray diffractometry (PXRD) and solid state 13 C nuclear magnetic resonance (NMR) spectroscopy. The molecular arrangement of the new polymorphic form IV of GBM was proposed. The GBM particles with polymorphic form IV also showed an improved dissolution behavior. In addition, it was found that the formation of the new polymorphic form IV of GBM by this process was reproducible.

Solid dispersion tablets of breviscapine with polyvinylpyrrolidone K30 for improved dissolution and bioavailability to commercial breviscapine tablets in beagle dogs.

PubMed

Cong, Wenjuan; Shen, Lan; Xu, Desheng; Zhao, Lijie; Ruan, Kefeng; Feng, Yi

2014-09-01

Breviscapine, one of cardiovascular drugs extracted from a Chinese herb Erigeron breviscapinus, has been frequently used to treat cardiovascular diseases such as hypertension, angina pectoris, coronary heart disease and stroke. However, its poor water solubility and low bioavailability in vivo severely restrict the clinical application. To overcome these drawbacks, breviscapine solid dispersion tablets consisting of breviscapine, polyvinylpyrrolidone K30 (PVP K30), microcrystalline cellulose and crospovidone were appropriately prepared. In vitro dissolution profiles showed that breviscapine released percentage of solid dispersion tablets reached 90 %, whereas it was only 40 % for commercial breviscapine tablets. Comparative pharmacokinetic study between solid dispersion tablets and commercial products was investigated on the normal beagle dogs after oral administration. Results showed that the bioavailability of breviscapine was greatly increased by 3.45-fold for solid dispersion tablets. The greatly improved dissolution rate and bioavailability might be attributed to intermolecular hydrogen bonding reactions between PVP K30 and scutellarin. These findings suggest that our solid dispersion tablets can greatly improve the bioavailability as well as the dissolution rate of breviscapine.

Synthesis of Polyvinylpyrrolidone (PVP)-Green Tea Extract Composite Nanostructures using Electrohydrodynamic Spraying Technique

NASA Astrophysics Data System (ADS)

Kamaruddin; Edikresnha, D.; Sriyanti, I.; Munir, M. M.; Khairurrijal

2017-05-01

Green Tea Extract (GTE) as an active substance has successfully loaded to PVP nanostructures using electrohydrodynamic spraying technique. The precursor solution was the mixture of ethanolic polyvinylpyrrolidone (PVP) with a molecular weight of 1,300 kg/mol and ethanolic GTE solutions at a weight concentration of 4 wt.% and 2 wt.%, respectively, and it was estimated that the entanglement number was 2. The electrospraying was conducted at the voltage of 15 kV, the flow rate of 10 µL/min., and the distance between the collector and the tip of the nozzle of 10 cm. The SEM images showed that the PVP/GTE nanostructures had a combination of agglomerated beads (less spherical particles) and nanofibers. This occurred because if the PVP concentration is low, the PVP/GTE composite has weak core structures that cause the shell to be easily agglomerated each other. The intermolecular interaction between PVP and GTE in the PVP/GTE nanostructures occurred as confirmed by the peak at 3396 cm-1, which is the carboxyl group, proving that the PVP/GTE nanostructures contained water, alcohols, and phenols. The peak at 1040 cm-1, which is the stretching of C-O group in amino acid, gave another proof to the intermolecular interaction.

Polymeric behavior evaluation of PVP K30-poloxamer binary carrier for solid dispersed nisoldipine by experimental design.

PubMed

Kyaw Oo, May; Mandal, Uttam K; Chatterjee, Bappaditya

2017-02-01

High melting point polymeric carrier without plasticizer is unacceptable for solid dispersion (SD) by melting method. Combined polymer-plasticizer carrier significantly affects drug solubility and tableting property of SD. To evaluate and optimize the combined effect of a binary carrier consisting PVP K30 and poloxamer 188, on nisoldipine solubility and tensile strength of amorphous SD compact (SD compact ) by experimental design. SD of nisoldpine (SD nisol ) was prepared by melt mixing with different PVP K30 and poloxamer amount. A 3 2 factorial design was employed using nisoldipine solubility and tensile strength of SD compact as response variables. Statistical optimization by design expert software, and SD nisol characterization using ATR FTIR, DSC and microscopy were done. PVP K30:poloxamer, at a ratio of 3.73:6.63, was selected as the optimized combination of binary polymeric carrier resulting nisoldipine solubility of 115 μg/mL and tensile strength of 1.19 N/m 2 . PVP K30 had significant positive effect on both responses. Increase in poloxamer concentration after a certain level decreased nisoldipine solubility and tensile strength of SD compact . An optimized PVP K30-poloxamer binary composition for SD carrier was developed. Tensile strength of SD compact can be considered as a response for experimental design to optimize SD.

Polyvinylpyrrolidone- (PVP-) coated silver aggregates for high performance surface-enhanced Raman scattering in living cells.

PubMed

Tan, Xuebin; Wang, Zhuyuan; Yang, Jing; Song, Chunyuan; Zhang, Ruohu; Cui, Yiping

2009-11-04

A biocompatible and stable surface-enhanced Raman scattering (SERS) probe has been successfully synthesized through a simple route with silver aggregates. Polyvinylpyrrolidone (PVP), a biocompatible polymer, was utilized to control the aggregation process and improve the chemical stability of the aggregates. Extinction spectroscopy and TEM results show the aggregation degree and core-shell structure of the probe. It is found that when we employ 4-mercaptobenzoic acid (4MBA), crystal violet (CV), Rhodamine 6G (R6G) or 4,4'-bipyridine molecules as Raman reporters, the SERS signal from the proposed probe can remain at a high level under aggressive chemical environments, even after being incorporated into living cells. In comparison with the traditional probes without the PVP shell, the new ones exhibit strong surface-enhanced effects and low toxicity towards living cells. We demonstrate that the PVP-coated silver aggregates are highly SERS effective, for which the fabrication protocol is advantageous in its simplicity and reproducibility.

Solid dispersion of efavirenz in PVP K-30 by conventional solvent and kneading methods.

PubMed

Alves, Lariza Darlene Santos; de La Roca Soares, Mônica Felts; de Albuquerque, Camila Tavares; da Silva, Elica Rodrigues; Vieira, Alexandre Couto Carneiro; Fontes, Danilo Augusto Ferreira; Figueirêdo, Camila Bezerra Melo; Soares Sobrinho, José Lamartine; Rolim Neto, Pedro José

2014-04-15

Efavirenz (EFV) used as a part of the treatment of first choice in antiretroviral therapy for AIDS has low aqueous solubility and presents problems of absorption. We thus initially present a phase solubility diagram with carriers of different classes. With a view to obtaining a solid dispersion (SD) with suitable consistency to that of a solid formulation, we chose to use PVP K-30, since polymers present some of the best results. The kneading (KN) and solvent evaporation (EV) methods were thus used at different rates. These were characterized by the way of DSC, FT-IR, SEM, DR-X and dissolution. SD EV proved unsatisfactory, resulting in a decreased dissolution rate, despite the amorphous state of the samples, while the SD KN 4:1 (EFV:polymer) and physical mixtures (PM) had a higher rate of dissolution. SD KN and PM 4:1 were also evaluated for stability after storage, with benefits being observed in relation to EFV. Copyright © 2014. Published by Elsevier Ltd.

Polyvinylpyrrolidone (PVP)-Capped Pt Nanocubes with Superior Peroxidase-Like Activity

SciTech Connect

Ye, Haihang; Liu, Yuzi; Chhabra, Ashima

2016-12-21

Peroxidase mimics of inorganic nanoparticles are expected to circumvent the inherent issues of natural peroxidases, providing enhanced performance in important applications such as diagnosis and imaging. Despite the report of a variety of peroxidase mimics in the past decade, very limited progress has been made on improving their catalytic efficiency. The catalytic efficiencies of most previously reported mimics are only up to one order of magnitude higher than those of natural peroxidases. In this work, we demonstrate a type of highly efficient peroxidase mimic â€" polyvinylpyrrolidone (PVP)-capped Pt nanocubes of sub-10 nm in size. These PVP-capped Pt cubes are ~200-foldmore » more active than the natural counterparts and exhibit a record-high specific catalytic efficiency. In addition to the superior efficiency, the new mimic shows several other promising features, including excellent stabilities, well-controlled uniformity in both size and shape, controllable sizes, and facile and scalable production.« less

Physiochemical Characterization and Release Rate Studies of SolidDispersions of Ketoconazole with Pluronic F127 and PVP K-30

PubMed Central

Kumar, Pankaj; Mohan, Chander; KanamSrinivasan Uma Shankar, Mara; Gulati, Monica

2011-01-01

In the present study solid dispersions of the antifungal drug Ketoconazole were prepared with Pluronic F-127 and PVP K-30 with an intention to improve its dissolution properties. Investigations of the properties of the dispersions were performed using release studies, Differential scanning calorimetery (DSC), X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR). The results obtained showed that the rate of dissolution of Ketoconazole was considerably improved when formulated in solid dispersions with PVP K-30 and Pluronic F-127 as compared with pure drug and physical mixtures. The results from DSC and XRD studies showed the transition of crystalline nature of drug to amorphous form, while FTIR studies demonstrated the absence of drug-carriers interaction. PMID:24250403

Temperature-responsive and biodegradable PVA:PVP k30:poloxamer 407 hydrogel for controlled delivery of human growth hormone (hGH).

PubMed

Taheri, Azade; Atyabi, Fatemeh; Dinarvnd, Rassoul

2011-01-01

Recombinant human growth hormone (rhGH) is used for replacement therapy of pediatric hypopituitary dwarfism. Growth rate in children was observed to be better on the daily injection schedule compared with the currently used therapeutic regimen of thrice a week injection. Thus, a controlled release formulation would overcome the drawback of traditional rhGH therapy such as the need for multiple injections. Poloxamers are a family of triblock copolymers consisting of two hydrophilic blocks of polyoxyethylene separated by a hydrophobic block of polyoxypropylene, which form micelles at low concentrations and form clear thermally reversible gels at high concentrations. We used poloxamer gels to develop a controlled release formulation of hGH. The objective of this study was to develop an in situ gel forming drug delivery system for hGH using the minimum possible ratio of poloxamer 407 (P407). Decreasing the concentration of poloxamer could reduce the risk of hypertriglyceridemia induction. Different additives were added to the poloxamer formulations. It was observed that among different additives polyvinylpyrrolidone k30 (PVP k30) and polyvinyl alcohol (PVA) decrease poloxamer concentration required to form in situ gelation from 18% to 10%. The dynamic viscoelastic properties of the samples were determined. Both the storage modulus and the loss modulus of the samples increased abruptly as the temperature passed a certain point. It can be concluded that combining P407 and PVP and PVA could be a promising strategy for preparation of thermally reversible in situ gel forming delivery systems of hGH with low poloxamer concentration.

Measurement of clay surface areas by polyvinylpyrrolidone (PVP) sorption and its use for quantifying illite and smectite abundance

USGS Publications Warehouse

Blum, A.E.; Eberl, D.D.

2004-01-01

A new method has been developed for quantifying smectite abundance by sorbing polyvinylpyrrolidone (PVP) on smectite particles dispersed in aqueous solution. The sorption density of PVP-55K on a wide range of smectites, illites and kaolinites is ~0.99 mg/m2, which corresponds to ~0.72 g of PVP-55K per gram of montmorillonite. Polyvinylpyrrolidone sorption on smectites is independent of layer charge and solution pH. PVP sorption on SiO2, Fe2O3 and ZnO normalized to the BET surface area is similar to the sorption densities on smectites. γ-Al2O3, amorphous Al(OH)3 and gibbsite have no PVP sorption over a wide range of pH, and sorption of PVP by organics is minimal. The insensitivity of PVP sorption densities to mineral layer charge, solution pH and mineral surface charge indicates that PVP sorption is not localized at charged sites, but is controlled by more broadly distributed sorption mechanisms such as Van der Waalsâ€TM interactions and/or hydrogen bonding. Smectites have very large surface areas when dispersed as single unit-cell-thick particles (~725 m2/g) and usually dominate the total surface areas of natural samples in which smectites are present. In this case, smectite abundance is directly proportional to PVP sorption. In some cases, however, the accurate quantification of smectite abundance by PVP sorption may require minor corrections for PVP uptake by other phases, principally illite and kaolinite. Quantitative XRD can be combined with PVP uptake measurements to uniquely determine the smectite concentration in such samples.

To study the linear and nonlinear optical properties of Se-Te-Bi-Sn/PVP (polyvinylpyrrolidone) nanocomposites

NASA Astrophysics Data System (ADS)

Tyagi, Chetna; Yadav, Preeti; Sharma, Ambika

2018-05-01

The present work reveals the optical study of Se82Te15Bi1.0Sn2.0/polyvinylpyrrolidone (PVP) nanocomposites. Bulk glasses of chalcogenide was prepared by well-known melt quenching technique. Wet chemical technique is proposed for making the composite of Se82Te15Bi1.0Sn2.0 and PVP polymer as it is easy to handle and cost effective. The composites films were made on glass slide from the solution of Se-Te-Bi-Sn and PVP polymer using spin coating technique. The transmission as well as absorbance is recorded by using UV-Vis-NIR spectrophotometer in the spectral range 350-700 nm. The linear refractive index (n) of polymer nanocomposites are calculated by Swanepoel approach. The linear refractive index (n) PVP doped Se82Te15Bi1.0Sn2.0 chalcogenide is found to be 1.7. The optical band gap has been evaluated by means of Tauc extrapolation method. Tichy and Ticha model was utilized for the characterization of nonlinear refractive index (n2).

Chitosan/zinc oxide-polyvinylpyrrolidone (CS/ZnO-PVP) nanocomposite for better thermal and antibacterial activity.

PubMed

Karpuraranjith, M; Thambidurai, S

2017-11-01

A new biopolymer based ZnO-PVP nanocomposite was successfully synthesized by single step in situ precipitation method using chitosan as biosurfactant, zinc chloride as a source material, PVP as stabilizing agent and sodium hydroxide as precipitating agent. The chemical bonding and crystalline behaviors of chitosan, zinc oxide and PVP were confirmed by FT-IR and XRD analysis. The biopolymer connected ZnO particles intercalated PVP matrix was layer and rod like structure appeared in nanometer range confirmed by HR-SEM and TEM analysis. The surface topography image of CS/ZnO-PVP nanocomposite was obtained in the average thickness of 12nm was confirmed by AFM analysis. Thermal stability of cationic biopolymer based ZnO intercalated PVP has higher stability than CS-PVP and chitosan. Consequently, antimicrobial activity of chitosan/ZnO-PVP matrix acts as a better microbial inhibition activity than PVP-ZnO nanocomposite. The obtained above results demonstrate that CS and ZnO intercalated PVP matrix has better reinforced effect than other components. Therefore, Chitosan/ZnO-PVP nanocomposite may be a promising material for the biomedical applications. Copyright © 2017 Elsevier B.V. All rights reserved.

The effect of minimal concentration of ethylene glycol (EG) combined with polyvinylpyrrolidone (PVP) on mouse oocyte survival and subsequent embryonic development following vitrification.

PubMed

Wang, Yao; Okitsu, Osamu; Zhao, Xiao-Ming; Sun, Yun; Di, Wen; Chian, Ri-Cheng

2014-01-01

Vitrification techniques employ a relatively high concentration of cryoprotectant in vitrification solutions. Exposure of oocytes to high concentrations of cryoprotectant is known to damage the oocytes via both cytotoxic and osmotic effects. Therefore, the key to successful vitrification of oocytes is to strike a balance between the usage of minimal concentration of cryoprotectant without compromising their cryoprotective actions. The minimal concentration of ethylene glycol (EG) on mouse oocyte survival and subsequent embryonic development was evaluated following vitrification-warming and parthenogenetic activation. Polyvinylpyrrolidone (PVP) combined with EG on mouse oocyte survival and subsequent embryonic development as well as morphology of the spindle and chromosome alignment were also evaluated. Vitrification system was adapted with JY Straw and the cooling rate was approximately 442-500 °C/min. In contrast, the warming rate was approximately 2,210-2,652 °C/min. Survival rate of oocytes increased significantly when 15 % EG was combined with 2 % PVP in vitrification solution (VS). The effect of combination of EG and PVP was not significant when the concentration of EG was 20 % and higher. Although there were no significant differences in embryonic development, the percentage of abnormal spindle and chromosome alignment was significantly higher in the oocytes without 2 % PVP in VS. Our data provide a proof of principle for oocyte vitrification that may not require a high concentration of cryoprotectant. There are synergic effects of EG combined with PVP for oocyte vitrification, which may provide important information to the field in developing less cytotoxic VS.

Hydrogels of polyvinylpyrrolidone (PVP) and poly(acrylic acid) (PAA) synthesized by radiation-induced crosslinking of homopolymers


pH-sensitive PVP-PAA hydrogels have been prepared by electron-beam-induced irradiation at pH close to pKa of carboxylic groups. Protonation of these groups promoted the formation of hydrogen bonds between the PAA and PVP segments within the crosslinked structure and caused interpolymer complex formation. To demonstrate possible future application of such gels, we tested them as simple chemical detectors. When loaded with glucose oxidase, the PAA-PVP gel's turbidity and shrinkage was triggered by the presence of glucose due to a drop in pH caused by the enzymatic reaction.

Porous PVDF/PANI ion-exchange membrane (IEM) modified by polyvinylpyrrolidone (PVP) and lithium chloride in the application of membrane capacitive deionisation (MCDI).

PubMed

Zhang, Yiming; Zhang, Wei; Cházaro-Ruiz, Luis F

2018-05-01

In this work, polyvinylidene fluoride (PVDF)/polyaniline (PANI) heterogeneous anion-exchange membranes filled with pore-forming agents polyvinylpyrrolidone (PVP) and lithium chloride were prepared by the solution-casting technique using the solvent 1-methyl-2-pyrrolidone (NMP) and a two-step phase inversion procedure. Key properties of the as-prepared membranes, such as hydrophilicity, water content, ion exchange capacity, fixed ion concentration, conductivity and transport number were examined and compared between membranes in different conditions. The pore-forming hydrophilic additives PVP and lithium chloride to the casting solution appeared to improve the ion-exchange membranes (IEMs) by increasing the conductivity, transport number and hydrophilicity. The effects of increasing membrane drying time on the porosity of the as-prepared membranes were found to lower membrane porosity by reducing membrane water content. However, pore-forming agents were found to be able to stabilise membrane transport number with different drying times. As-prepared PVDF/PANI anion-exchange membrane with pore-forming agent is demonstrated to be a more efficient candidate for water purification (e.g. desalination) and other industrial applications.
Violent reaction with: Strong alkali
10.4 Conditions to avoid
Protect from moisture. Keep away from heat. Decompostion takes place from temperatures above:
>130 °C.
10.5 Incompatible materials
There is no additional information.
10.6 Hazardous decomposition products
Hazardous combustion products: see section 5.
SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity
Exposure route Endpoint Value Species Source
oral LD50 >2,000 mg/kg rat TOXNET
Skin corrosion/irritation
Shall not be classified as corrosive/irritant to skin.
Serious eye damage/eye irritation
Shall not be classified as seriously damaging to the eye or eye irritant.
Respiratory or skin sensitisation
Shall not be classified as a respiratory or skin sensitiser.
Safety data sheet
Safe Work Australia - Code of Practice
Polyvinylpyrrolidone K 30 extra pure
article number: 4607
Australia (en) Page 6 / 11
Summary of evaluation of the CMR properties
Shall not be classified as germ cell mutagenic, carcinogenic nor as a reproductive toxicant
• Specific target organ toxicity - single exposure
Shall not be classified as a specific target organ toxicant (single exposure).
• Specific target organ toxicity - repeated exposure
Shall not be classified as a specific target organ toxicant (repeated exposure).
Aspiration hazard
Shall not be classified as presenting an aspiration hazard.
Symptoms related to the physical, chemical and toxicological characteristics
• If swallowed
data are not available
• If in eyes
data are not available
• If inhaled
Inhalation of dust may cause irritation of the respiratory system
• If on skin
data are not available
Other information
None
SECTION 12: Ecological information
12.1 Toxicity
acc. to 1272/2008/EC: Shall not be classified as hazardous to the aquatic environment.
Aquatic toxicity (acute)
Endpoint Value Species Exposure time
LC50 >10,000 mg/l orfe (Leuciscus idus) 96 h
12.2 Process of degradability
Theoretical Oxygen Demand with nitrification: Theoretical Oxygen Demand: Theoretical Carbon Dioxide:
12.3 Bioaccumulative potential
Data are not available.
12.4 Mobility in soil
Data are not available.
12.5 Results of PBT and vPvB assessment
Data are not available.
12.6 Other adverse effects
Data are not available.
Safety data sheet
Safe Work Australia - Code of Practice
Polyvinylpyrrolidone K 30 extra pure
article number: 4607
Australia (en) Page 7 / 11
SECTION 13: Disposal considerations
13.1 Waste treatment methods
This material and its container must be disposed of as hazardous waste. Dispose of contents/container in accordance with local/regional/national/international regulations.
Sewage disposal-relevant information
Do not empty into drains.
Sewage disposal-relevant information
Do not empty into drains.
13.2 Relevant provisions relating to waste
The allocation of waste identity numbers/waste descriptions must be carried out according to the
EEC, specific to the industry and process.
13.3 Remarks
Waste shall be separated into the categories that can be handled separately by the local or national
waste management facilities. Please consider the relevant national or regional provisions.
SECTION 14: Transport information
14.1 UN number (not subject to transport regulations)
14.2 UN proper shipping name not relevant
14.3 Transport hazard class(es) not relevant
Class -
14.4 Packing group not relevant
14.5 Environmental hazards none (non-environmentally hazardous acc. to the dangerous goods regulations)
14.6 Special precautions for user
There is no additional information.
14.7 Transport in bulk according to Annex II of MARPOL and the IBC Code
The cargo is not intended to be carried in bulk.
14.8 Information for each of the UN Model Regulations
• Transport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN)
Not subject to ADR, RID and ADN.
• International Maritime Dangerous Goods Code (IMDG)
Not subject to IMDG.
• International Civil Aviation Organization (ICAO-IATA/DGR)
Not subject to ICAO-IATA.
Safety data sheet
Safe Work Australia - Code of Practice
Polyvinylpyrrolidone K 30 extra pure
article number: 4607
Australia (en) Page 8 / 11
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National inventories
Country National inventories Status
AU AICS substance is listed
CA DSL substance is listed
CN IECSC substance is listed
JP CSCL-ENCS substance is listed
KR KECI substance is listed
MX INSQ substance is listed
NZ NZIoC substance is listed
PH PICCS substance is listed
TW TCSI substance is listed
US TSCA substance is listed
Legend
AICS Australian Inventory of Chemical Substances
CSCL-ENCS List of Existing and New Chemical Substances (CSCL-ENCS)
DSL Domestic Substances List (DSL)
IECSC Inventory of Existing Chemical Substances Produced or Imported in China
INSQ National Inventory of Chemical Substances
KECI Korea Existing Chemicals Inventory
NZIoC New Zealand Inventory of Chemicals
PICCS Philippine Inventory of Chemicals and Chemical Substances
TCSI Taiwan Chemical Substance Inventory
TSCA Toxic Substance Control Act
15.2 Chemical Safety Assessment
No Chemical Safety Assessment has been carried out for this substance.
SECTION 16: Other information
16.1 Indication of changes (revised safety data sheet)
Section Former entry (text/value) Actual entry (text/value) Safetyrelevant
2.1 Classification acc. to GHS:
This substance does not meet the criteria for
classification in accordance with Regulation No
1272/2008/EC. This substance does not meet
the criteria for classification.
Classification acc. to GHS yes
2.1 Classification acc. to GHS:
change in the listing (table)
yes
2.2 Labelling GHS:
not required
Labelling GHS yes
2.2 Signal word:
not required
Signal word:
Warning
yes
2.2 Hazard statements yes
2.2 Hazard statements:
change in the listing (table)
yes
Safety data sheet
Safe Work Australia - Code of Practice
Polyvinylpyrrolidone K 30 extra pure
article number: 4607
Australia (en) Page 9 / 11
Section Former entry (text/value) Actual entry (text/value) Safetyrelevant
2.2 Precautionary statements yes
2.2 Precautionary statements - response yes
2.2 Precautionary statements - response:
change in the listing (table)
yes
2.2 Labelling of packages where the contents do
not exceed 125 ml:
Signal word: Warning
yes
2.2 Labelling of packages where the contents do
not exceed 125 ml:
change in the listing (table)
yes
2.2 Labelling of packages where the contents do
not exceed 125 ml:
change in the listing (table)
yes
Abbreviations and acronyms
Abbr. Descriptions of used abbreviations
ADN Accord européen relatif au transport international des marchandises dangereuses par voies de navigation
intérieures (European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways)
ADR Accord européen relatif au transport international des marchandises dangereuses par route (European
Agreement concerning the International Carriage of Dangerous Goods by Road)
CAS Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)
CMR Carcinogenic, Mutagenic or toxic for Reproduction
DGR Dangerous Goods Regulations (see IATA/DGR)
GHS "Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations
IATA International Air Transport Association
IATA/DGR Dangerous Goods Regulations (DGR) for the air transport (IATA)
ICAO International Civil Aviation Organization
IMDG International Maritime Dangerous Goods Code
MARPOL International Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")
PBT Persistent, Bioaccumulative and Toxic
REACH Registration, Evaluation, Authorisation and Restriction of Chemicals
RID Règlement concernant le transport International ferroviaire des marchandises Dangereuses (Regulations
concerning the International carriage of Dangerous goods by Rail)
vPvB very Persistent and very Bioaccumulative
Key literature references and sources for data
- UN Recommendations on the Transport of Dangerous Good
- Dangerous Goods Regulations (DGR) for the air transport (IATA)
- International Maritime Dangerous Goods Code (IMDG)
List of relevant phrases (code and full text as stated in chapter 2 and 3)
Safety data sheet
Safe Work Australia - Code of Practice
Polyvinylpyrrolidone K 30 extra pure
article number: 4607
Australia (en) Page 10 / 11
Code Text
H303 may be harmful if swallowed
Disclaimer
The above information describes exclusively the safety requirements of the product and is based on
our present-day knowledge. The information is intended to give you advice about the safe handling of
the product named in this safety data sheet, for storage, processing, transport and disposal. The information cannot be transferred to other products. In the case of mixing the product with other
products or in the case of processing, the information on this safety data sheet is not necessarily valid for the new made-up material.
Safety data sheet
Safe Work Australia - Code of Practice
Polyvinylpyrrolidone K 30 extra pure
article number: 4607

anım

: Belirsiz kokulu renksiz-sarımsı solüsyonlar ve beyaz toz formunda.

 

 

 

 

 

 

Spesifikasyonlar

:

 

Ürün

K değeri

(%1 Etanol'de)

Katı içeriği, %

Su, %

PH değeri, (%10 sulu çözelti)

NVP içeriği %

Vac içeriği %

PVP/VA 37 E

: 28,0-36,0

: 48,0-52,0

: <0,5

: -

: <0,01

: <0,03

PVP/VA 37 I

: 25,0-31,0

: 48,0-52,0

: <0,5

: -

: <0,01

: <0,03

PVP/VA 55 I

: 22,0-28,0

: 48,0-52,0

: <0,5

: -

: <0,01

: <0,03

PVP/VA 64 Powder

: 26,0-34,0

: >% 95

: <0,5

. 3,8-6,0

: <0,01

: <0,03

PVP/VA 64 W

: 26,0-34,0

: 48,0-52,0

: Yak.50

: 5,0-7,0

: <0,01

: <0,03

PVP/VA 73 W

: 24,0-32,0

: 48,0-52,0

: Yak.50

: 5,0-7,0

: <0,01

: <0,03

PVP/VA 73 E

: 28,0-38,0

: 48,0-52,0

: <0,5

: -

: <0,01

: <0,03


Özellikleri: Etanoik (E), izopropanoik (I) ve sulu (W) çeşitlerinin her biri yaklaşık %50 polimer içerir. PVP VA 64 Powder yaklaşık % 100 toz üründür. PVP/VA tipleri, saç fixative (sabitleyici) olarak özellikle aerosol spreylerinde, pompa spreylerinde, sıvı ürünlerde, mousse'ler ve jellerde kullanılan non-iyonik, polimerik film oluşturucu ajanlardır.

Çözünürlük: PVP VA'nın sudaki çözünürlük derecesi, VP/VA oranına bağlıdır. Yüksek vinil prolidon oranlı ürünler (PVP/VA 64 ve PVP/VA 73) suda berrak çözeltiler oluşturur. Diğer çeşitler suda dağıtılabilir. Çözeltileri hafif asidiktir. Polimerler non-iyoniktir, bu yüzden nötralize edilmeye ihtiyaç duymazlar. Bütün PVP cinsleri, etanol, izopropanol, n-propanol, gliserin, metilen klorür, esterler ve ketonlarda çözünürler. Etanol ve izopropanol'deki çözeltilerinde soğukta oluşan tortular, ısıtmayla tekrar ortadan kalkar. PVP/VA 37, etanol abs., etanol % 96 ve etanol/su (VOC % 80 ve VOC % 55) içinde berrak çözelti oluştururlar. İzopropanoldeki çözeltiler berrak, zaman zaman mavimsi tondadır. Bu ürünler bir çözücü olmadan eter ve alifatik hidrokarbonlarda çözünürler.

Saç spreylerine uygunluk: PVP/VA tipleri film oluşturucu ajanlar olarak ve fixative olarak saç bakımlarında kullanılırlar. Aerosol spreyleri ve aerosol olmayan ürünlerin her ikisi için de mükemmel özelliklere sahiptir. Vinil prodilon'un daha yüksek bir oranı, PVP/VA tipini olduğundan daha higroskopik yapar. PVP/VA filmlerinin (örn; PVP/VA 64 ve PVP/VA 73) saça yapışması, polimerin non-iyonik yapısı sayesinde vinil prolidonun oranıyla mükemmel tarama ve yıkama (sonrası) özelliklerine ters etki olmaksızın artar. PVP/VA 37 ve PVP/VA 55 özellikle, filmlerinin fırçalamayla saçtan uzaklaşması mümkün olması gereken saç spreyleri için kullanışlıdır. Bu saç, fırçalamayla tekrar yağlansa bile, yağ Luviskol filmiyle birlikte etkili bir şekilde uzaklaşır.

PVP/VA 64 tipleri ve PVP/VA 55 tipleri, tersine, özellikle hidrofilik bir yapıya sahip olacak olan saç spreyleri için tercih edilir.(örn, kuru havada kullanım için). Ayrıca yüksek bir su içeriğine sahip spreyler için kullanışlıdır. Kırılgan ve kuru saç için olan saç spreyleri bir polietilen glikol benzeri Peg 400, veya dimetil ftalat, Luvitol EHO, silikon yağları veya , kozmetikte sıkça kullanılan diğer plastikleştiriciler gibi plastikleştiricinin küçük bir miktarını (% 0,1-0,2) içermelidirler.

Propellant (itici) uyumluluğu: PVP/VA tiplerinin uyumluluğu dimetil eterle iyi bir şekilde uyumludur. Propan, butan, izobutan, pentan DME/pentan ve DME/butan karışımları etanol ve metilen klorür gibi solventlerle birlikte kullanılabilir.

Saç ayarlama çözeltileri ve jellere uyumluluğu: Sudaki iyi çözünürlüğü nedeniyle PVP/VA 64 ve PVP/VA 73 özellikle sıvı saç şekillendirici ürünler ve jeller için kullanışlıdır. Dahası, bu polimerler mükemmel şekillendirme özelliklerine sahiptirler. Bütün bu PVP/VA tipleri, düz bir şekilde yıkamayla saçtan tamamiyle uzaklaştırılabilir.

Hem PVP/VA 64 toz hem de PVP/VA'nın kolay kullanılan sulu çözeltileri, özellikle alkol bulundurmayan formülasyonlar için uygundur. Genel konsantrasyonlarda (%1-5 katı polimer) suda berrak çözeltiler oluştururlar ve karbomerlerle uyumludurlar. PVP/VA 37'nin orta kararda hidrokarbon uyumluluğu, küçük miktarlarda su ekleyerek ilerletilebilir. Bu, onun 0 oC'nin altında bir bulanma noktasını elde etmeyi muhtemel kılar.

Uygulama örnekleri: Saç spreylerinin bileşimi faktörlerin bir sayısına bağlıdır. Bunlar; saç tipi (kalın,ince, kuru, yağlı), hava (kuru,nemli), yasal gereklilikler ve çeşitli iticilerin uygunluk statüleri, solvent sistemi (susuz veya suyla birlikte) ve tüketici alışkanlıkları'dır. Aerosol spreyleri durumunda, en uygun formülasyonun seçim faaliyetini gerçekleştirmek için, bulanma noktası, yoğunluk ve basınç verilmiştir. Her formülasyona bir numara tahsil edilmiştir. Saç spreyleri ve şekillendiricilerin(ayarlayıcı) üretiminde, olabilecek herhangi partikülleri uzaklaştırmak için doldurmadan önce solüsyonun filtrasyonu önemlidir.

 

Aerosol saç spreyleri

: % 2-6

Pompa spreyler

: % 3-7

Şekillendirme losyonları, Setting mousse, Jeller, Saç waxları

: % 1-5

 

 

 

ETİKETLER : PVP / VA ( POLİVİNİL PROLİDON ) NEDİR,PVP / VA ( POLİVİNİL PROLİDON ) NEREDE KULLANILIR,PVP / VA ( POLİVİNİL PROLİDON ) NEDEN KULLANILIR,PVP / VA ( POLİVİNİL PROLİDON ) HANGİ ÜRÜNLERDE KULLANILIR,PVP / VA ( POLİVİNİL PROLİDON ) FORMÜLÜ,PVP / VA ( POLİVİNİL PROLİDON ) FORMÜLLERİ,PVP / VA ( POLİVİNİL PROLİDON ) MSDS,PVP / VA ( POLİVİNİL PROLİDON ) KİMYASAL VE FİZİKSEL ÖZELLİKLERİ,PVP / VA ( POLİVİNİL PROLİDON ) HANGİ ALANLARDA KULLANILIR,PVP / VA ( POLİVİNİL PROLİDON ) ÖZELLİKLERİ,PVP / VA ( POLİVİNİL PROLİDON ) ÇEŞİTLERİ,PVP / VA ( POLİVİNİL PROLİDON ) TÜRLERİ.

olymers (PVP); Hydrophilic Polymers; Hydrophobic Polymers; Materials Science; Poly(vinylpyrrolidinone) (PVP); Poly(vinylpyrrolidone); Poly(vinylpyrrolidone) (PVP) and Copolymers; Polymer Science, Polymers, Vinylpyridine and Vinypyrrolidone Polymers; Plasdone, PVP, Polyvidone, Povidone; 2-Pyrrolidinone, 1-ethenyl-, homopolymer (9003-39-8); PVP, Povidone; PVPP, Crospovidone, Polyvidone; PNVP; Poly[1-(2-oxo-1-pyrrolidinyl)ethylen]; 1-Ethenyl-2-pyrrolidon homopolymer; 1-Vinyl-2-pyrrolidinon-Polymere; k25; k60; POP; PVP; k115; pvp2; pvp3; pvp4; pvp5; pvp6; Kollidon 25; Homopolymer of Vinylpyrrolidone; Polyvinylpyrrolidone; 1-Ethenyl-2-pyrrolidinone homopolymer; 1-Ethenyl-2-pyrrolidinone polymers; 1-Ethenyl-2-pyrrolidinone, homopolymer; 1-Vinyl-2-pyrrolidinone homopolymer; 1-Vinyl-2-pyrrolidinone polymer; 1-Vinyl-2-pyrrolidone polymer; 143 RP; 2-Pyrrolidinone, 1-ethenyl, homopolymer; 2-Pyrrolidinone, 1-vinyl-, polymers; 2-Pyrrolidinone, 1-vinyl-, polymers, compd. with aluminum acetate; Agent AT 717; alpha-Hydro-omega-(p-iodobenzyl)poly(1-(2-oxo-1-pyrrolidinyl)ethylene)-(sup 131)I; alpha-Hydro-omega-(p-iodobenzyl)poly(1-(2-oxo-1-pyrrolidinyl)ethylene)-(sup 131)I.; (A small part of the iodine is the radioactive isotope, (sup 131)I.); Antaron P 804; AT 717; Caswell No. 681; CCRIS 3611; Crospovidone; Crospovidonum; Crospovidonum, [INN-Latin]; EPA Pesticide Chemical Code 079033; 1-vinylpyrrolidin-2-one homopolymer; Plasdone K29-32; Plasdone K29/32; Polyvinylpyrrolidone K 30; Polyvinylpyrrolidone K-29/32; Polyvinylpyrrolidone K30; Povidone K29-32; Povidone K29/32; PVP K-30; PVP K30; PVP-K 30; Ganex P 804; Ganex p-804; Hemodesis; Hemodez; HSDB 205; K 115 (polyamide); K 115 (VAN); K 15; K 25 (polymer); K 25 (VAN); K 30 (polymer); K 30 (VAN); K 60 (polymer); K 60 (VAN); K 90; Peviston; Plasdone; Plasdone 4; Plasdone K 29-32; Plasdone K-26/28; Plasdone No. 4; N-Vinyl-2-pyrrolidone polymer; N-Vinylbutyrolactam polymer; N-Vinylpyrrolidinone polymer; N-Vinylpyrrolidone polymer; Plasdone XL; Plasmosan; Polividona; Polividona [INN-Spanish]; Polividone; Polividone [DCIT]; Poly(1-(2-oxo-1-pyrrolidinyl)-1,2-ethanediyl), alpha-hydro-omega-((4-(iodo-(sup 131)I)phenyl)methyl)-; Poly(1-(2-oxo-1-pyrrolidinyl)ethylene); Poly(1-ethenyl-2-pyrrolidinone); Poly(1-vinyl-2-pyrrolidinone); Poly(1-vinyl-2-pyrrolidinone) homopolymer; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.1; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.2; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.3; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.4; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.5; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.6; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.7; Poly(1-vinyl-2-pyrrolidone); Poly(1-vinylpyrrolidinone); Poly(N-vinyl-2-pyrrolidinone); Poly(N-vinyl-2-pyrrolidone); Poly(N-vinylbutyrolactam); Poly(N-vinylpyrrolidinone); Poly(N-vinylpyrrolidone); Poly(vinylpyrrolidinone); Poly-N-vinyl pyrrolidone; Toxobin; UNII-2S780E561; UNII-333AG72FWJ; UNII-40UAA97IT9; UNII-68401960MK; UNII-6B46OH7T95; UNII-C67P1734QJ; UNII-E54VE15114; UNII-FZ989GH94E; UNII-H7AGY1OJO8; UNII-K0KQV10C35; UNII-RDH86HJV5Z; UNII-SZR7Z3Q2YH; UNII-U725QWY32X; Vinisil; Vinylpyrrolidinone polymer; Vinylpyrrolidone polymer; polivinilpirolidon; Poli (vinylpolypyrrolidone); Polivinilpirolidon ve Vinilpirolidon Kopolimerleri (PVP); Hidrofilik Polimerler; Hidrofobik Polimerler; Malzeme Bilimi; Poli (vinilpirolidinon) (PVP); Poli (vinilpirolidon); Poli (vinilpirolidon) (PVP) ve Kopolimerler; Polimer Bilimi, Polimerler, Vinilpiridin ve Vinipirrolidon Polimerler; Plasdone, PVP, Polyvidone, Povidone; 2-Pirolidinon, 1-etenil-, homopolimer (9003-39-8); PVP, Povidon; PVPP, Crospovidone, Polyvidone; PNVP; Poli [1- (2-okso-1-pirrolidinil) etilen]; 1-Etenil-2-pirolidon homopolimeri; 1-vinil-2-pirrolidinon-Polymere; K25; K60; POP; PVP; k115; pvp2; pvp3; pvp4; pvp5; pvp6; Kollidon 25; Vinylpirolidonun Homopolimeri; polivinilpirolidon; 1-Etenil-2-pirolidinon homopolimeri; 1-Etenil-2-pirolidinon polimerleri; 1-Etenil-2-pirolidinon, homopolimer; 1-Vinil-2-pirolidinon homopolimeri; 1-Vinil-2-pirolidinon polimer; 1-Vinil-2-pirolidon polimer; 143 RP; 2-Pirolidinon, 1-etenil, homopolimer; 2-Pirolidinon, 1-vinil-, polimerler; 2-Pirolidinon, 1-vinil-, polimerler, compd. alüminyum asetat ile; Ajan 717; alfa-Hidro-omega- (p-iyodobenzil) poli (1- (2-okso-1-pirolidinil) etilen) - (sup 131) I; alfa-Hidro-omega- (p-iyodobenzil) poli (1- (2-okso-1-pirolidinil) etilen) - (sup 131) I; (İyotun küçük bir kısmı, radyoaktif izotoptur, (sup 131) I); Antaron P 804; AT 717; Caswell No. 681; CCRIS 3611; Krospovidon; Crospovidonum; Crospovidonum, [INN-Latin]; EPA Pestisit Kimyasal Kodu 079033; 1-vinilpirolidin-2-on homopolimer; Plasdone K29-32; Plasdone K29 / 32; Polivinilpirolidon K 30; Polivinilpirolidon K-29/32; Polivinilpirolidon K30; Povidone K29-32; Povidone K29 / 32; PVP K-30; PVP K30; PVP-K30; Ganex P 804; Ganex p-804; Hemodesis; Hemodez; HSDB 205; K 115 (poliamid); K 115 (VAN); K 15; K25 (polimer); K25 (VAN); K30 (polimer); K30 (VAN); K60 (polimer); K 60 (VAN); K 90; Peviston; Plasdone; Plazdon 4; Plasdon K 29-32; Plasdon K-26/28; 4 No'lu Plasdone; N-Vinil-2-pirolidon polimer; N-Vinylbutyrolaktam polimer; N-Vinilpirrolidinon polimer; N-Vinilpirrolidon polimer; Plasdone XL; Plasmosan; Polividona; Polividona [INN-İspanyolca]; Polividone; Polividone [DCIT]; Poli (1- (2-okso-1-pirolidinil) -1,2-etandiil), alfa-hidro-omega - ((4- (iyodo- (sup 131) I) fenil) metil) -;
Poli (1- (2-okso-1-pirrolidinil) etilen); Poli (1-etenil-2-pirrolidinon); Poli (1-vinil-2-pirrolidinon); Poli (1-vinil-2-pirolidinon) homopolimeri; Poli (1-vinil-2-pirolidinon) Hueter Polimer No.1; Poli (1-vinil-2-pirolidinon) Hueper Polimer No.2; Poli (1-vinil-2-pirolidinon) Hueper Polimer No.3; Poli (1-vinil-2-pirolidinon) Kaliper Polimer No.4; Poli (1-vinil-2-pirolidinon) Daha Dayanıklı Polimer No.5; Poli (1-vinil-2-pirolidinon) Kaliper Polimer No.6; Poli (1-vinil-2-pirolidinon) Daha Dayanıklı Polimer No. 7; Poli (1-vinil-2-pirolidon); Poli (1-vinilpirolidinondur); Poli (N-vinil-2-pirrolidinon); Poli (N-vinil-2-pirolidon); Poli (N-Vinilbutirolaktam); Poli (N-vinilpirolidinondur); Poli (N-vinil pirolidon); Poli (vinilpirolidinondur); Poli-N-vinil pirolidon; Toxobin; LXVIII-2S780E561; LXVIII-333AG72FWJ; LXVIII-40UAA97IT9; LXVIII-68401960MK; LXVIII-6B46OH7T95; LXVIII-C67P1734QJ; LXVIII-E54VE15114; LXVIII-FZ989GH94E; LXVIII-H7AGY1OJO8; LXVIII-K0KQV10C35; LXVIII-RDH86HJV5Z; LXVIII-SZR7Z3Q2YH; LXVIII-U725QWY32X; Vinisil; Vinilpirrolidinon polimer; Vinilpirrolidon polimer; pvpK 30; PVPK30; PVP, K, 30; pvp, k, 30; Polyvinylpyrrolidone; Poly, vinyl, pyrro, lidone; pvpk30; PVPK, 30; Poly(vinylpolypyrrolidone); Polyvinylpyrrolidone and Vinylpyrrolidone Copolymers (PVP); Hydrophilic Polymers; Hydrophobic Polymers; Materials Science; Poly(vinylpyrrolidinone) (PVP); Poly(vinylpyrrolidone); Poly(vinylpyrrolidone) (PVP) and Copolymers; Polymer Science, Polymers, Vinylpyridine and Vinypyrrolidone Polymers; Plasdone, PVP, Polyvidone, Povidone; 2-Pyrrolidinone, 1-ethenyl-, homopolymer (9003-39-8); PVP, Povidone; PVPP, Crospovidone, Polyvidone; PNVP; Poly[1-(2-oxo-1-pyrrolidinyl)ethylen]; 1-Ethenyl-2-pyrrolidon homopolymer; 1-Vinyl-2-pyrrolidinon-Polymere; k25; k60; POP; PVP; k115; pvp2; pvp3; pvp4; pvp5; pvp6; Kollidon 25; Homopolymer of Vinylpyrrolidone; Polyvinylpyrrolidone; 1-Ethenyl-2-pyrrolidinone homopolymer; 1-Ethenyl-2-pyrrolidinone polymers; 1-Ethenyl-2-pyrrolidinone, homopolymer; 1-Vinyl-2-pyrrolidinone homopolymer; 1-Vinyl-2-pyrrolidinone polymer; 1-Vinyl-2-pyrrolidone polymer; 143 RP; 2-Pyrrolidinone, 1-ethenyl, homopolymer; 2-Pyrrolidinone, 1-vinyl-, polymers; 2-Pyrrolidinone, 1-vinyl-, polymers, compd. with aluminum acetate; Agent AT 717; alpha-Hydro-omega-(p-iodobenzyl)poly(1-(2-oxo-1-pyrrolidinyl)ethylene)-(sup 131)I; alpha-Hydro-omega-(p-iodobenzyl)poly(1-(2-oxo-1-pyrrolidinyl)ethylene)-(sup 131)I.; (A small part of the iodine is the radioactive isotope, (sup 131)I.); Antaron P 804; AT 717; Caswell No. 681; CCRIS 3611; Crospovidone; Crospovidonum; Crospovidonum, [INN-Latin]; EPA Pesticide Chemical Code 079033; 1-vinylpyrrolidin-2-one homopolymer; Plasdone K29-32; Plasdone K29/32; Polyvinylpyrrolidone K 30; Polyvinylpyrrolidone K-29/32; Polyvinylpyrrolidone K30; Povidone K29-32; Povidone K29/32; PVP K-30; PVP K30; PVP-K 30; Ganex P 804; Ganex p-804; Hemodesis; Hemodez; HSDB 205; K 115 (polyamide); K 115 (VAN); K 15; K 25 (polymer); K 25 (VAN); K 30 (polymer); K 30 (VAN); K 60 (polymer); K 60 (VAN); K 90; Peviston; Plasdone; Plasdone 4; Plasdone K 29-32; Plasdone K-26/28; Plasdone No. 4; N-Vinyl-2-pyrrolidone polymer; N-Vinylbutyrolactam polymer; N-Vinylpyrrolidinone polymer; N-Vinylpyrrolidone polymer; Plasdone XL; Plasmosan; Polividona; Polividona [INN-Spanish]; Polividone; Polividone [DCIT]; Poly(1-(2-oxo-1-pyrrolidinyl)-1,2-ethanediyl), alpha-hydro-omega-((4-(iodo-(sup 131)I)phenyl)methyl)-; Poly(1-(2-oxo-1-pyrrolidinyl)ethylene); Poly(1-ethenyl-2-pyrrolidinone); Poly(1-vinyl-2-pyrrolidinone); Poly(1-vinyl-2-pyrrolidinone) homopolymer; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.1; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.2; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.3; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.4; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.5; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.6; Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.7; Poly(1-vinyl-2-pyrrolidone); Poly(1-vinylpyrrolidinone); Poly(N-vinyl-2-pyrrolidinone); Poly(N-vinyl-2-pyrrolidone); Poly(N-vinylbutyrolactam); Poly(N-vinylpyrrolidinone); Poly(N-vinylpyrrolidone); Poly(vinylpyrrolidinone); Poly-N-vinyl pyrrolidone; Toxobin; UNII-2S780E561; UNII-333AG72FWJ; UNII-40UAA97IT9; UNII-68401960MK; UNII-6B46OH7T95; UNII-C67P1734QJ; UNII-E54VE15114; UNII-FZ989GH94E; UNII-H7AGY1OJO8; UNII-K0KQV10C35; UNII-RDH86HJV5Z; UNII-SZR7Z3Q2YH; UNII-U725QWY32X; Vinisil; Vinylpyrrolidinone polymer; Vinylpyrrolidone polymer; polivinilpirolidon; Poli (vinylpolypyrrolidone); Polivinilpirolidon ve Vinilpirolidon Kopolimerleri (PVP); Hidrofilik Polimerler; Hidrofobik Polimerler; Malzeme Bilimi; Poli (vinilpirolidinon) (PVP); Poli (vinilpirolidon); Poli (vinilpirolidon) (PVP) ve Kopolimerler; Polimer Bilimi, Polimerler, Vinilpiridin ve Vinipirrolidon Polimerler; Plasdone, PVP, Polyvidone, Povidone; 2-Pirolidinon, 1-etenil-, homopolimer (9003-39-8); PVP, Povidon; PVPP, Crospovidone, Polyvidone; PNVP; Poli [1- (2-okso-1-pirrolidinil) etilen]; 1-Etenil-2-pirolidon homopolimeri; 1-vinil-2-pirrolidinon-Polymere; K25; K60; POP; PVP; k115; pvp2; pvp3; pvp4; pvp5; pvp6; Kollidon 25; Vinylpirolidonun Homopolimeri; polivinilpirolidon; 1-Etenil-2-pirolidinon homopolimeri; 1-Etenil-2-pirolidinon polimerleri; 1-Etenil-2-pirolidinon, homopolimer; 1-Vinil-2-pirolidinon homopolimeri; 1-Vinil-2-pirolidinon polimer; 1-Vinil-2-pirolidon polimer; 143 RP; 2-Pirolidinon, 1-etenil, homopolimer; 2-Pirolidinon, 1-vinil-, polimerler; 2-Pirolidinon, 1-vinil-, polimerler, compd. alüminyum asetat ile; Ajan 717; alfa-Hidro-omega- (p-iyodobenzil) poli (1- (2-okso-1-pirolidinil) etilen) - (sup 131) I; alfa-Hidro-omega- (p-iyodobenzil) poli (1- (2-okso-1-pirolidinil) etilen) - (sup 131) I; (İyotun küçük bir kısmı, radyoaktif izotoptur, (sup 131) I); Antaron P 804; AT 717; Caswell No. 681; CCRIS 3611; Krospovidon; Crospovidonum; Crospovidonum, [INN-Latin]; EPA Pestisit Kimyasal Kodu 079033; 1-vinilpirolidin-2-on homopolimer; Plasdone K29-32; Plasdone K29 / 32; Polivinilpirolidon K 30; Polivinilpirolidon K-29/32; Polivinilpirolidon K30; Povidone K29-32; Povidone K29 / 32; PVP K-30; PVP K30; PVP-K30; Ganex P 804; Ganex p-804; Hemodesis; Hemodez; HSDB 205; K 115 (poliamid); K 115 (VAN); K 15; K25 (polimer); K25 (VAN); K30 (polimer); K30 (VAN); K60 (polimer); K 60 (VAN); K 90; Peviston; Plasdone; Plazdon 4; Plasdon K 29-32; Plasdon K-26/28; 4 No'lu Plasdone; N-Vinil-2-pirolidon polimer; N-Vinylbutyrolaktam polimer; N-Vinilpirrolidinon polimer; N-Vinilpirrolidon polimer; Plasdone XL; Plasmosan; Polividona; Polividona [INN-İspanyolca]; Polividone; Polividone [DCIT]; Poli (1- (2-okso-1-pirolidinil) -1,2-etandiil), alfa-hidro-omega - ((4- (iyodo- (sup 131) I) fenil) metil) -;
Poli (1- (2-okso-1-pirrolidinil) etilen); Poli (1-etenil-2-pirrolidinon); Poli (1-vinil-2-pirrolidinon); Poli (1-vinil-2-pirolidinon) homopolimeri; Poli (1-vinil-2-pirolidinon) Hueter Polimer No.1; Poli (1-vinil-2-pirolidinon) Hueper Polimer No.2; Poli (1-vinil-2-pirolidinon) Hueper Polimer No.3; Poli (1-vinil-2-pirolidinon) Kaliper Polimer No.4; Poli (1-vinil-2-pirolidinon) Daha Dayanıklı Polimer No.5; Poli (1-vinil-2-pirolidinon) Kaliper Polimer No.6; Poli (1-vinil-2-pirolidinon) Daha Dayanıklı Polimer No. 7; Poli (1-vinil-2-pirolidon); Poli (1-vinilpirolidinondur); Poli (N-vinil-2-pirrolidinon); Poli (N-vinil-2-pirolidon); Poli (N-Vinilbutirolaktam); Poli (N-vinilpirolidinondur); Poli (N-vinil pirolidon); Poli (vinilpirolidinondur); Poli-N-vinil pirolidon; Toxobin; LXVIII-2S780E561; LXVIII-333AG72FWJ; LXVIII-40UAA97IT9; LXVIII-68401960MK; LXVIII-6B46OH7T95; LXVIII-C67P1734QJ; LXVIII-E54VE15114; LXVIII-FZ989GH94E; LXVIII-H7AGY1OJO8; LXVIII-K0KQV10C35; LXVIII-RDH86HJV5Z; LXVIII-SZR7Z3Q2YH; LXVIII-U725QWY32X; Vinisil; Vinilpirrolidinon polimer; Vinilpirrolidon polimer;

CAS NUMBER: 9003-39-8
Linear Formula (C6H9NO)n
MDL number MFCD00149016
3D model (JSmol)
Interactive image
Abbreviations PVP, PVPP, NVP, PNVP
ChEMBL
ChEMBL1909074 ☒
ChemSpider
none
ECHA InfoCard 100.111.937
E number E1201 (additional chemicals)
SMILES

Properties
Chemical formula
(C6H9NO)n
Molar mass 2,500 - 2,500,000 g·mol-1
Appearance white to light yellow, hygroscopic, amorphous powder
Density 1.2 g/cm3
Melting point 150 to 180 °C (302 to 356 °F; 423 to 453 K) (glass temperature)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Appearance (Colour) White to off - white
Appearance (Form) Crystalline powder
Solubility (Turbidity) 10% aq. solution Clear
Nitrogen content (N) 11.5 - 12.5%
pH (5% aq. solution) 3.0 - 7.0
Sulphated Ash max. 0.1%
Heavy Metals (Pb) max. 0.001%
K-value ~ 30
Vinyl pyrrolidone max. 0.8%
Water (KF) max. 5%

PVP K-30 is a hygroscopic, amorphous polyvinylpyrrolidone. Used in industrial, specialty and imaging coatings & paints and as a media component in digital ink jet-printing. Offers high polarity, dispersancy, hydrophilicity, adhesion, cohesivity and high glass transition temperature. PVP K-30 can be plasticized with water and most common organic plasticizers. They are linear nonionic polymers thar are soluble in water and organi solvents and are pH stable. pvp k 30 forms hard glossy transparent films and have adhesive, cohesive and dispersive properties.
PVP K-30 100% Powder is soluble in water and many organic solvents and it forms hard, transparent, glossy film. PVP is compatible with most inorganic salts and many resins. PVP stabilizes emulsions, dispersions and suspensions. While PVP is used as a film former in hair styling products, PVP can also be used as an emulsion stabilizer in creams and lotions and as a dispersant for hair colorants. Additionally, pharmaceutical grade PVP can be used in toothpastes and mouthwashes. PVP K-30 100% Powder appears as a white powder.
Applications
adhesives, ceramics, glass (fibers), coating/inks, electronic appliations, lithography and photography, fibers and textiles, membranes, metallurgy, paper, polymerizations, water and waste teratment, and hygiene.

Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone:
PVP was used as a plasma volume expander for trauma victims after the 1950s.

It is used as a binder in many pharmaceutical tablets;[2] it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.[3] The long-term effects of crospovidone or povidone within the lung are unknown.)
PVP added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.[4] This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others.
It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.[5]
PVP is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Examples of this use include Bausch & Lomb's Ultra contact lenses with MoistureSeal Technology[6] and Air Optix contact lens packaging solution (as an ingredient called "copolymer 845").[7]
PVP is used as a lubricant in some eye drops, Soothe.[8]

Technical
PVP is also used in many technical applications:
as an adhesive in glue stick and hot-melt adhesivesas a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process
as an emulsifier and disintegrant for solution polymerization to increase resolution in photoresists for cathode ray tubes (CRT)[9] in aqueous metal quenching for production of membranes, such as dialysis and water purification filters
as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating
as a thickening agent in tooth whitening gels[10]
as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation
as an additive to Doro's RNA extraction buffer[citation needed]
as a liquid-phase dispersion enhancing agent in DOSY NMR [11]
as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly[12]
as a stabilizing agent in all inorganic solar cells[13]

Other uses
PVP binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers.
PVP is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions.[14][15] PVP is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some.
As a food additive, PVP is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers.
In molecular biology, PVP can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.
In microscopy, PVP is useful for making an aqueous mounting medium.[16]
PVP can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.[17]

Safety
The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses,[18] and it is generally considered safe. However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP has come in contact with autologous serum (internal blood fluids) and mucous membranes. For example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP component of the solution.[19] A woman, who had previously experienced urticaria (hives) from various hair products, later found to contain PVP, had an anaphylactic response after povidone-iodine solution was applied internally. She was found to be allergic to PVP.[20] In another case, a man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP.[21]
Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses, although testing results in some patients show no signs of allergy to the suspect chemical. Allergies attributed to these other chemicals may possibly be caused by the PVP instead.[22][23]

Properties
PVP is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol,[24] as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin).[25] When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings.
A 2014 study found fluorescent properties of PVP and its oxidized hydrolyzate.[26]

History
PVP was first synthesized by Walter Reppe and a patent was filed in 1939 for one of the derivatives of acetylene chemistry. PVP was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production

Vinylpyrrolidone polymer
Polyvinylpyrrolidone is abbreviated as PVP, and is the polymer of vinylpyrrolidone. According to the different degree of polymerization, it is further classified into soluble PVP and insoluble PVPP (polyvinyl polypyrrolidone). Molecular weight of the soluble PVP is 8,000 to 10,000.The soluble PVP can be used as a precipitating agent which can be settle down through its action with polyphenols. Using this method, it is easily to have residual PVP in the alcohol. Due to the savings effect of PVP inside the human body, the World Health Organization doesn't recommend to apply this substance. In recent years, the use of soluble PVP has been rare. Insoluble PVPP system had began to be used in the beer industry since the early 1960s. It has a relative molecule weight greater than the relative mass greater than 700,000. It is a insoluble polymer derived from the further cross-linking and polymerization of PVP and can be used as an adsorbent of polyphenols with a good efficacy.
The molecular formula of Polyvinylpyrrolidone
The molecular formula of Polyvinylpyrrolidone
Polyvinylpyrrolidone PVP is one of the three major pharmaceutical new excipients and can be used as the co-solvent of tablets, granules, and injection, as the glidant of capsules, as the dispersant agent of liquid preparations and the colorant, as the stabilizer of enzyme and heat sensitive drug, as the co-precipitating agent of poorly soluble drugs, and as the detoxicant of ophthalmic drugs and lubricants.
It is industrially used as expanded polystyrene additive, as the gelling agents for suspension polymerization, stabilizer, and fiber treating agents, paper processing aids, adhesives, and thickening agents.
Polyvinylpyrrolidone PVP and its copolymers CAP is an important raw material of cosmetics, mainly used for hair retaining agent. The film it formed in the hair is elastic and shiny, and has excellent carding property as well as being free of dust. Adopting different category of resin can meet various kinds of relative humidity climatic conditions. Therefore, it is an indispensable raw material in styling hair cream, hair gel, and mousse. It can also be used for the cosmetics of skin moisturizing agents and the dispersants for grease based hair dying, also as foam stabilizers, and can improve the consistency of the shampoo.
Insoluble PVP is the stabilizer of beer and juice which can improve its transparency, color, and flavor.
Water-soluble polyamides
Polyvinyl pyrrolidone (PVP) is a water soluble polyamide. Commercially available PVP is divided into four viscosity grades according to its press K value (Fikentscher K value): K-15, K-30, K-60, K-90, with the average molecular weight being 10,000, 40000,160000, and 360000, respectively. K value or molecular weight is an important factor which decides the various properties of PVP.
Polyvinyl pyrrolidone (PVP) is dissolved in water, chlorinated solvents, alcohol, amine, nitro-paraffin and low molecular weight fatty acids, and is mutually soluble with most inorganic salts and a variety of resin; insoluble in acetone and ether. PVP used for the matrix of dropping pill matrix is odorless, tasteless, white to pale yellow waxy solid with the relative density being 1.062, and its 5% aqueous solution pH being 3 to 7. PVP is hygroscopic and of good thermal stability, and can be dissolved in various kinds of organic solvents, and has high melting point. Adding certain natural or synthetic polymers or organic compounds can effectively adjust the PVP's hygroscopicity and softness. PVP is not prone to have chemical reaction. Under normal storage conditions, dry PVP is quite stable. PVP has excellent physical inertia and biocompatibility and has not stimulation to skin, eyes no stimulation with no allergic reactions and being non-toxic.
Because of the hydrogen bonding or complexation effect, PVP's viscosity is increased and this further inhibits the formation and growth of crystallized nuclei of drugs, making the drug being in the amorphous state. The dropping pill whose matrix is PVP can enhance the dissolution and bioavailability of poorly soluble drugs. In general, the greater the PVP amount, the higher dissolution and solubility of drug in the medium. Susana et al have studied the dissolution of the PVP solid dispersant of the slightly soluble drug albendazole. The increased amount of PVP (k30) can increase the dissolution rate and efficiency of drug inside the solid dispersant. Teresa et al have studied the dissolution of the poorly soluble drugs, flunarizine in PVP solid dispersant and obtained similar conclusion. PVP also found that the higher the content, the more significant increase in dissolution. IR has showed that flunarizine and PVP has no chemical reaction except in some cases that a best dissolution efficacy is obtained only in certain ratio between some drugs with the PVP. Tantishaiyakul et al has found that: when the ratio of piroxicam: PVP is 1:5 and 1:6, the dissolution of the solid dispersant is the largest with a 40 times as high as that of single drug within 5min.
PVP can also be dissolved in another molten dropping pill matrix, such as polyethylene glycol (PEG), polyoxyethylene monostearate (S-40), poloxamer and stearyl acid, glyceryl monostearate, etc for making complex matrix.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Physical and chemical properties
Commonly used PVP level in the cosmetic industry is K-30. Commercialized PVP is white and free flowing powder or solids with its content in the mass fraction of 20%, 30%, 45% and 50% aqueous solution. PVP is soluble in water and is hygroscopic with a moisture equilibrium being 1/3 of the relative humidity of the environment. Similar as the protein hydration action, each monomer associates with 0.5mol water.Chart 1 and Chart 2 lists the reference quality standard of various types of polyvinylpyrrolidone PVP:
Food grade and pharmaceutical grade polyvinylpyrrolidone PVP
Chart 1: Food grade and pharmaceutical grade polyvinylpyrrolidone PVP
Cosmetics and industrial polyvinylpyrrolidone PVP (Luvikol K, BASF)
Chart 2: Cosmetics and industrial polyvinylpyrrolidone PVP (Luvikol K, BASF)
PVP is not easy to have chemical reaction. When stored at normal conditions, dry PVP is quite stable. Solution undergone mildew treatment is also stable. When heated in air to 150 °C or mixed with ammonium persulfate to heat at 90 °C for 30min, PVP will be exchanged to become a water-insoluble compound. In the presence of azo compound or a dichromate oxidizing agent, light will cause PVP solution to become gel. The co-heating of PVP solution with strong base (such as sodium silicate or trisodium phosphate) will generate precipitation. Many different compounds can generate complexes with PVP. For example, the complexes of PVP and iodine is very stable and have a good bactericidal effect and can reduce its toxicity; Adding the copolymers of the polyacrylic acid, tannic acid or methyl vinyl ether and maleic acid to the aqueous solution of PVP will generate insoluble complexes which are insoluble in water, alcohols and ketones. But when being treated with base for neutralize the poly-acid can reverse the reaction; complexation between PVP and toxins, drugs and toxic chemicals can reduce their toxicity; some kinds of dyes can also form a strong complex with PVP, which is the basis for using PVP as a dye bleaching agent.
The use of polyvinylpyrrolidone
In the early 1950s, older, with shellac and oil-based hairspray had been rapidly replaced by PVP sprays which are still widely used until now. It can form wet, transparent film on the hair which is shiny and has good lubrication effect. PVP has good compatibility with a variety of good propellant and also has corrosion resistance. It is widely used in hair styling, as the film former in combing products, as the creatinine and stabilizer of skin care lotions and creams, as the base stock material for eye and facial cosmetics and lipstick base, and also as hair dye dispersants and shampoo foam stabilizer. PVP has detoxification effect and can reduce the irritation effects of other preparation on the skin and eyes. It is also used as toothpaste detergents, gelling agents and antidotes. The main drawback of PVP is its sensitivity to moisture. However, this issue can be tackled by using its vinyl acetate copolymer in order to mitigate the effects of moisture and humidity. In addition, PVP also has wide application in the pharmaceutical, beverage and textile industries.
Rheological properties of solutions
Water and methanol is the preferred solvent of PVP. pH value has little effect on the viscosity of the aqueous solution of PVP, for example, at 25 °C, pH range: 0.1~10, aqueous solution of PVP K-30 with a mass fraction of 5% concentration has a viscosity of 2.3~2.4mPa • s; in concentrated hydrochloric acid, this is 4.96mPa • s. Effect of temperature on the viscosity of the PVP aqueous solution is also relatively not obvious. Un-cross-linked PVP solution is not particularly thixotropic unless under very high concentration and display a short relaxation time. The chart 3 below lists the viscosity of PVP K-30 in a variety of solvents.
Viscosity of PVP K-30 in various organic solvents (w %) (At room temperature)
Chart 3: Viscosity of PVP K-30 in various organic solvents (w %) (At room temperature)
Reference: Edited by Binyi Qiu, "Compendium of cosmetic chemistry and technology" Volume 1 Beijing: China Light Industry Press, 1997.
Compatibility
Polyvinylpyrrolidone is mainly used as pharmaceutical excipient, blood compatibilizer, cosmetics thickening agents, latex stabilizers, and clarifying agent of beer brewing.
Not matter whether in solution or in the form of film, PVP always has a high degree of compatibility. It has good compatibility with various kinds of inorganic salt solution, many natural and synthetic resins and other chemical compatibility. Examples of their compatibility are seen at chart 4 and Figure 5.
The compatibility of PVP and some other substances in water and ethanol
Chart 4: The compatibility of PVP and some other substances in water and ethanol The solubility and compatibility of PVP in various solvents
Chart 5: The solubility and compatibility of PVP in various solvents
Safety
PVP is physiologically inert. Acute oral toxicity of PVP: LD50 > 100g/kg. It does not irritate the skin or eyes, do not cause skin allergies. A large number of long-term toxicology studies have confirmed that polyvinylpyrrolidone (PVP) can tolerate intraperitoneal, intramuscular, intravenous administration and parenteral applications. Subacute and chronic toxicity result was negative.
Identification test
Solubility: soluble in water, ethanol and chloroform and insoluble in ether. This is measured by the OT-42 method.
Dichromate precipitation test: in 5 mL of2% sample solution, add 5 mL dilute hydrochloric acid solution (TS-117), further add 5 mL of water plus 2 mL of 10% potassium dichromate solution and 2ml. This should form an orange precipitate.
Take 75 mg of cobalt nitrate and 300 mg of ammonium thiocyanate for being dissolved in 2ml of water; add 5 mL of 2% aqueous sample solution; after the mixing, add dilute hydrochloric acid test solution (TS-117) for acidification. This should form light blue precipitate.
Take 5 mL of 2% sample solution; add 1 mL of 25% hydrochloric acid, 5 mL of 5% barium chloride and 1 mL 5% molybdenum tungsten phosphoric acid solution. This should generate a lot of white precipitate which gradually turns blue in the sunlight.
The pH value of 5% sample solution should be 3.0 to 3.7. This is measured by conventional means.
Adding a few drops of iodine test solution (TS-124) to 5 mL of 0.5% sample solution should produce a deep red color.
Take 1 g of sample, add water to 10 ml as a suspension, add 0.1 mL of iodine test solution (TS-124), after mixing by shaking for 30s, iodine test solution should fade (to distinguish polyvinylpyrrolidone due to that polyvinylpyrrolidone can form red color). Add 1 mL of starch test solution (TS-235), after shaking and mixing, there should be no blue color formed. to produce blue.
Content Analysis
Estimated from the nitrogen content according to the following index of quality.
Toxicity
ADI 0~50 (FAO/WHO, 2001)
LD50> 100g/kg (rat, oral).
ADI does not make special provision (FAO/WHO, 2001).
It is safe for food (FDA, §121.1110, §173.50, 2000).
LD50:12g/kg (mice, abdominal injection).
Limited use
GB 2760-1996: beer GMP.
Chemical Properties
It is the cross-linked homopolymer of pure vinylpyrrolidone. It is hygroscopic and free-flowing white or off-white powder. It has a slight foul smell. It is insoluble in common solvents such as water, ethanol and ether. So its molecule weight range can't be measured. However, PVP has ability to form complex with various kinds of substances (such as "Hu" class substance which can lead to the discoloration of a variety of wines and beverages discoloration). Also it is easily to be removed after filtration because of its insolubility.
Uses
Clarifying agent; pigment stabilizer; colloidal stabilizer; It is mainly used for beer clarifying and quality stabilizing (reference amount 8~20g/100L, maintained for 24h and remove it by filtration), and can also be applied in combination with enzymes (protease) and protein adsorbents. It is also used to clarify the wine and as a stabilizer to prevent discoloration (reference amount 24~72g/100L).
Clarifying agents; stabilizers; thickeners agent; tablet fillers; dispersants; PVP of molecular weight 360,000 are often used as the clarifying agent of beer, vinegar, and grape wine.
Used as the fixing liquid for gas chromatography.
It is used as a colloidal stabilizer and clarifying agent for beer clarification. Apply proper amount according the demands of production.
It can be used for pharmacy, aquaculture, and livestock disinfectant for the sterilization of the skin and mucous.
PolyFilterTM molecule has an amide bond for absorbing the hydroxyl groups located in polyphenol molecule to form hydrogen bonds, and therefore, can be used as the stabilizer of beer, fruit wine/grape wine, and drinking wine to extend their shelf life and improve the transparency, color and taste. The products have two specifications: disposable type and regeneration type. Disposable products are suitable for application by SMEs; renewable products demand the purchase of special filtration equipment; but since it is recyclable, it is suitable for large breweries for recycle application.
In daily cosmetics, PVP and its copolymer has good dispersion property and filming property, and thus being able to be used as a setting lotion, hair spray and styling mousse, as opacifiers for hair care agents, as the stabilizer of shampoo foam, as wave styling agent and as the dispersants and affinity agents in hair dye. Adding PVP to cream, sunscreen, and hair removal agent can enhance wetting and lubricating effect. Taking advantage of the excellent properties of PVP such as surface activity, film-forming and non-irritating to the skin, no allergic reactions, etc., has broad prospects in its application in hair care and skin care products.
Production method
Its crude product comes from the polymerization of vinylpyrrolidone under basic catalyst or the existence of N, N'-divinyl amidine and further cross-inking reaction. Then use water, 5% acetic acid and 50% ethanol for reflux to until extract ≤50mg/kg (for over 3h).
The 30% to 60% aqueous solution of the purified 1-vinyl-2-pyrrolidone, in the presence of ammonia or amines and also with hydrogen peroxide as the catalyst, has cross-linking and homo-polymerization reaction at a temperature of 50 °C and subject to further purification to obtain the final product.
Chemical Properties
Hygroscopic, white or yellowish-white powder or flakes.
Chemical Properties
Povidone occurs as a fine, white to creamy-white colored, odorless or almost odorless, hygroscopic powder. Povidones with K-values equal to or lower than 30 are manufactured by spray-drying and occur as spheres. Povidone K-90 and higher K-value povidones are manufactured by drum drying and occur as plates.
Uses
suitable for gene delivery
Definition
ChEBI: A vinyl polymer composed of repeating -CH2-CR- units where R is a 2-oxopyrrolidin-1-yl group.
Production Methods
Povidone is manufactured by the Reppe process. Acetylene and formaldehyde are reacted in the presence of a highly active copper acetylide catalyst to form butynediol, which is hydrogenated to butanediol and then cyclodehydrogenated to form butyrolactone. Pyrrolidone is produced by reacting butyrolactone with ammonia. This is followed by a vinylation reaction in which pyrrolidone and acetylene are reacted under pressure. The monomer, vinylpyrrolidone, is then polymerized in the presence of a combination of catalysts to produce povidone.
brand name
Kollidon CL (BASF); Kollidon CLM (BASF); Polyplasdone (International Specialty Products);Acu-dyne;Adapettes;Adsorbobase;Adsovbotear;Agent at 717;Albigen a;Aldacol q;Amiorel eritro;Amyderm s;Andrestrac 2-10;Anexa;B 7509;Betaisod;Bridine;Clinidine;Final step;Frepp/sepp;Ganex p 804;Ga-pvp-101;Gyno-bidex;Isoplasma;Jodoplex;K 115;Kollidon 17;Kollidon 25;Kollidon 30;Kollidon 90;Kollidon ce 50/50;Kollidon k 25;Kollidon k 30;Luviskol k 17;Luviskol k 25;Luviskol k 30;Luviskol k 90;Luvisteol;Medicort;Molycu;Mundidon;Neojodin;Oftan flurekain;Peragal st;Periston-n-toxobin;Pevidine;Plasmadone;Plasmoid;Plassint;Podiodine;Polyclar at;Polyclar h;Polyclar l;Polyplasdone xl;Polyvidone-escupient;Polyvinyl pyrrolidone;Povadyne;Povidone k 29-32;Pvp 50;Pvp0;Pvp-k 15;Pvp-k 25;Pvp-k 30;Pvp-k 60;Pvp-k 90;Pvp-macrose;Pvp-macrox;Rocmuth;Sd 13;Soft-care;Tears plus;Venostasin retard;Vetedine;Yodiplexin.
World Health Organization (WHO)
Polyvidone, a polymer of vinylpyrrolidinone, is an excipient used as a suspending and dispersing agent. Injectable preparations containing polymers with a molecular weight in the order of 12,000 have caused painful local granulomatous lesions. This has led to the withdrawal of polyvidone from such preparations in some countries. Polyvidone was formerly also used as a plasma expander but, because it was sequestered within the liver and spleen, this use has been discontinued. However, it remains widely used as a vehicle for ophthalmic preparations, and as the major component of artificial tears.
General Description
White powder. Compatible with a wide range of hydrophilic and hydrophobic resins.
Air & Water Reactions
Hygroscopic. Water soluble.
Reactivity Profile
Polyvinylpyrrolidone is a polymeric material and probably has low reactivity. Polyvinylpyrrolidone reacts as a weak base.
Hazard
Questionable carcinogen.
Health Hazard
SYMPTOMS: Polyvinylpyrrolidone may cause interstitial fibrosis in the lungs. Lesions regress when patient is no longer being exposed to the compound.
Fire Hazard
Flash point data for Polyvinylpyrrolidone are not available, but Polyvinylpyrrolidone is probably non-flammable.
Pharmaceutical Applications
Although povidone is used in a variety of pharmaceutical formulations, it is primarily used in solid-dosage forms. In tableting, povidone solutions are used as binders in wet-granulation processes.Povidone is also added to powder blends in the dry form and granulated in situ by the addition of water, alcohol, or hydroalcoholic solutions. Povidone is used as a solubilizer in oral and parenteral formulations, and has been shown to enhance dissolution of poorly soluble drugs from solid-dosage forms. Povidone solutions may also be used as coating agents or as binders when coating active pharmaceutical ingredients on a support such as sugar beads.
Povidone is additionally used as a suspending, stabilizing, or viscosity-increasing agent in a number of topical and oral suspensions and solutions. The solubility of a number of poorly soluble active drugs may be increased by mixing with povidone.
Special grades of pyrogen-free povidone are available and have been used in parenteral formulations;
Contact allergens
Polyvinylpyrrolidone is widely used as is in cosmetics such as hair care products and in medical products. It acts as iodophor in iodine-polyvinylpyrrolidone. PVP is an irritant and has been claimed as the allergen in some cases of dermatitis from iodine-polyvinylpyrrolidone (although iodine is more likely the hapten). It may cause type I contact urticaria or anaphylaxis.
Safety Profile
Mtldly toxic by intraperitoneal and intravenous routes. Questionable carcinogen. When heated to decomposition it emits toxic fumes of NOx.
Safety
Povidone has been used in pharmaceutical formulations for many years, being first used in the 1940s as a plasma expander, although it has now been superseded for this purpose by dextran.
Povidone is widely used as an excipient, particularly in oral tablets and solutions. When consumed orally, povidone may be regarded as essentially nontoxic since it is not absorbed from the gastrointestinal tract or mucous membranes.Povidone additionally has no irritant effect on the skin and causes no sensitization. exists that povidone may accumulate in the organs of the body following intramuscular injection.
A temporary acceptable daily intake for povidone has been set by the WHO at up to 25 mg/kg body-weight.
(mouse, IP): 12 g/kg
storage
Povidone darkens to some extent on heating at 150°C, with a reduction in aqueous solubility. It is stable to a short cycle of heat exposure around 110-130°C; steam sterilization of an aqueous solution does not alter its properties. Aqueous solutions are susceptible to mold growth and consequently require the addition of suitable preservatives.
Povidone may be stored under ordinary conditions without undergoing decomposition or degradation. However, since the powder is hygroscopic, it should be stored in an airtight container in a cool, dry place.
Purification Methods
Purify it by dialysis, and freeze-drying. Also by precipitation from CHCl3 solution by pouring into ether. Dry it in a vacuum over P2O5. For the crosslinked polymer purification is by boiling for 10minutes in 10% HCl and then washing with glass-distilled water until free from Cl ions. Finally, Cl ions are removed more readily by neutralising with KOH and continued washing.
Incompatibilities
Povidone is compatible in solution with a wide range of inorganic salts, natural and synthetic resins, and other chemicals. It forms molecular adducts in solution with sulfathiazole, sodium salicylate, salicylic acid, phenobarbital, tannin, and other compounds; see Section 18. The efficacy of some preservatives, e.g. thimerosal, may be adversely affected by the formation of complexes with povidone.

Traditional High-Efficient Rheology Modifier Carbomer
Efficient Rheology Modifier For Home Care
Traditional Long-Flow Property Carbomer
Improved Type - Easy To Disperse Carbomer
Improved Type -Self-Wetting Carbomer
Improved Type Carbomer
Liquid Carbomer
Pharmaceutical Grade Carbomer
Home Care Carbomer
High Carlity Traditional Carbomer
Benzen Free Carbomer
Homopolymer Of Vinylpyrrolidone
NM-PVP K30

Chemical Name: Homopolymer of Vinylpyrrolidone
CTFA Name :Polyvinylpyrrolidone

NM-PVP K30 can dissolve in water and grain alcohol, isopropyl alcohol or chloroform, but not in acetone or diethyl ether. Have good absorption moisture, film-forming, complex ability. It is a high performance, versatile polymer widely used in pharmaceutical field, cosmetics field, beer, water treatment membrane, detergents, paints and other fields.

Application
1. Pharma application: Used as binder for tablet and pellet, dissolving assistant for injection, flowing assistant capsule, dispersant for liquid medicine and pigment, stabilizer for enzyme and heat sensitive drug.
2. Cosmetic application: Used extensively in a wide range hair care, skin care &oral care products. The products are particularly suitable for formulation where viscosity modification and film forming properties are required.
3. Tech application: As surface coating agent, dispersing agent, thickener, binder, porogen in water treatment membrane ( hollow fiber membrane, ultrafiltration membrane, nanofiltration membrane, etc.), paint, printing ink, textile, printing and drying color picture tubes.
A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander. See povidone for full details.
Indication
When in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.

Pharmacodynamics
Povidone itself has no microbicidal activity. Povidone-iodine exhibits rapid, potent, broad-spectrum antimicrobial properties 2. The clinical effectiveness of povidon-iodine on wound healing remains somewhat controversial; in few clinical studies investigating the effects of povidone-iodine on wound healing, topical administration of the complex was associated with no significant infections, but slower healing and mild to moderate discomfort on application 1.

Mechanism of action
Povidone-iodine is a water-soluble complex that mediates a bactericidal or virucidal action following the gradual liberation of free iodine from the complex at the application site to react with the pathogen 1. Please refer to the drug entry for Povidone-iodine for the full mechanism of action of the complex.

Molecular Formula: (-CH(NCH2CH2CH2CO)CH2
-)n
Molecular Weight: 35,000-51,000
CAS # : 9003-39-8
Synonym: PVP
Physical Description: White to off white powder
Solubility: Soluble in water (> 100 mg/ml), methanol, ethanol, alcohol, chloroform and glycerol, acetic acid; insoluble in dimethyl ether,
ethyl acetate, acetone, toluene, xylene, mineral oil, carbon tetrachloride. If the pH value of the solutions is higher than 6, the viscosity
will increase slightly on storage, particularly at elevated temperatures; if the pH value is less than 7 and the concentration is lower than
30%, the solutions tend to become moldy during storage.1 The addition of a preservative can prevent mold and fungus growth during
storage. Addition of large quantities of salts will precipitate the PVP from solution.
Molecular Weight 10 K 30 K 40 K 360 K
K value*: 12-18 27-33 28-32 90-103
Synonym: PVP K 15 PVP K 30 PVP K 30 PVP K 90
Bulk Density (lb/cu ft) 36 29 20 --
*K values are derived from viscosity measurements and are calculated according to Fikentscher's formula.
Description: Typically used as thickeners, dispersing agents, detoxicant, complexing agent, lubricants and binders.
Availability:
Catalog Number Description Size
196056 Polyvinylpyrrolidone, average MW 10000;
typically used as a cryoprotectant and in
plant cell cultures.
100 g
500 g
102786 Polyvinylpyrrolidone, average MW 30000 100 g
500 g
1 kg
5 kg
195451 Polyvinylpyrrolidone, average MW 40000 100 g
500 g
1 kg
102787 Polyvinylpyrrolidone, average MW 360000 100 g
500 g
1 kg
5 kg
194017 Polyvinylpyrrolidone, average MW 360000,
molecular biology reagent; typically used in
nucleic acid hybridizations.
100 g
500 g
1 kg

Povidone
Povidones are available in different molecular weights. The higher the molecular weight, the greater the viscosity and consequently the adhesive strength. The K-value denotes the intrinsic viscosity of the polymer related to the molecular weight, and is derived from the relative viscosity of the aqueous solution measured at 25°C. The direct correlation between the molecular weight and properties enables the appropriate grade to be used in each formulation in the appropriate concentration in order to achieve the optimum effect.

In order to provide formulators with flexibility in the choice of wet granulation binders with good adhesive strength and ease of handing, JRS PHARMA offers 2 grades of wet binders:
PVP K30 and VIVAPHARM® PVP K25.
PVP K30
29.0 - 32.0
5.5 - 8.5
PVP K30 and K25 are low viscosity wet binders with a good balance between adhesive strength and ease of handling. It is highly adhesive at low viscosity, thus offering the optimal balance between adhesive strength and ease of handling at 2-5% (PVP K30) or 4-7% (PVP K25).
PVP K30 and K25 has excellent solubility in water and a range of organic solvents, and is supplied as a free flowing powder with spherical particle morphology.
This ensures rapid dispersibility and ultimate flexibility in the solvent of choice. Due to its non-ionic property, it does not bear any risk of interaction with ionic APIs.
Tanım
: Hafif karakteristik kokulu beyaz toz.
Ambalaj birimi

: 90 kg PE varil.
Cas No
: 9003-39-8
Kimyasal adı
: Vinilprolidonun homopolimerleri (polivinilprolidon).
Spesifikasyonlar
:
PVP K 30 Toz
Vinil prolidon

: < 2 mg/kg
Katı içerik
: 96,3 g/100 g
K değeri
: 30,0
pH değeri, %10 suda
: 3,4
Monomer ünitesi molekül ağırlığı: 111,14 g/mol
Sulu çözeltileri berrak ve renksiz-hafif sarımsı'dır. Toz ürünler, beyazdır.
Çözünürlük: Suda,etanol ve izopropanolde çözünür. Elektrolitik karaktere sahip değildir. Sulu çözeltileri, farklı suda çözünen selüloz türevlerinin çözletileriyle karıştırılabilir. Onlar genelde kullanılan non-iyonik, anyonik veya katyonik ürünlerle ve poliakrilatlar, poliquatlar, tuzlar, asitler ve bazlarla kombine edilebilirler. PVP K çeşitleri, nispeten yüksek miktarda tuz eklenmesiyle çözeltilerden çöktürülebilir. PVP K 90, K 17'den hissedilir derecede daha fazla çökme gösterir. PVP'nin farklı organik solventlerdeki çözünürlüğü geniş bir alanda farklılık gösterir. PVP K çeşitleri en az % 10 PVP içeren çözeltiler verecek şekilde aşağıdaki solventlerde çözünürler:
Alkoller: Etanol, n-propanol,izopropanol, n-butanol, 2-etil-1-hekzanol, siklohekzanol, metilsiklohekzanol, propilen glikol, 1,3-butandiol, metilizobutil karbinol, gliserol.

Esterler: etil laktat
Eter Alkolleri: Hekzaetilen glikol, dietilenglikol, monometil eter, polietilen glikol 400, etilenglikol monoetil eter, dietilen glikol, trietilenglikol
Ketonlar: siklohekzanon (ısıtarak) metil siklo hekzanon,
Asitler: Formik asit, asetik asit, propiyonik asit
Aminler: sikloheksilamin, dietanolamin, trietanol amin, etilendiamin, monoetanol amin
Depolama: 6'nın üzerindeki pH ‘a sahip sulu çözeltilerin viskositesi, artan sıcaklık ve uzayan depolama sırasında artar. %30'un altındaki konsantrasyonlardaki asitleştirilmiş çözeltiler, depolama sırasında küf gelişimine eğilim gösterirler.Bu polihekzametilen biguadin HCl gibi bir koruyucu eklenerek önlenebilir. OH veya NH2 gruplarıyla reaksiyon veren koruyucularun kullanımı önerilmez.
PVP K 80'in K değeri istisnai olarak uzun depolama sırasında düşer.
Depolama ve kararlılık: PVP K 17,30,80 ve 90 çözeltileri 25 oC'nin altında açılmamış orijinal ambalajında en az 3 yıl raf ömrüne sahiptir. PVP K 30, 80, 85Q ve K90 çözeltileri 20 oC'nin altında tercihen 4 oC'de açılmamış orijinal ambalajında en az 2 yıl raf ömrüne sahiptir.
Uygulamalar ve teknik özellikler: Kozmetikte çeşitli uygulamalar için kullanılır. Kalınlaştırıcı ajanlar, emülsifiyerler, yağlayıcı ve bağlayıcılar olarak kozmetikte kullanılırlar. Temizleyici, boya veya cilt ve saç görünümünü yükselten kozmetik ürünlerine eklenmesi uygundur. PVP K 30 toz ve PVP K 90 toz yağlı ve yağsız bazlı belirli kremlerin her ikisininde formülasyonlarında kulllanılabilir. PVP K 30 saç şekillendirici preparatlarda sertleştirici ajan olarak rol oynar ve şampuanların, saç boyası ve benzeri preparatların kıvamını ayarlar. PVP K 30 toz, cildi korumak amacıyla şampuan ve ev deterjanlarına eklenebilir. Anyonik kolloidlerin tersine, PVP K 30 toz'un boyaları bağlama eğiliminde olduğu hesaba katılması gerekmesine rağmen, PVP K çeşitleri örn;bazik boyalar ve katyonik maddelerle birleştirilebilirler. PVP K 30 Toz, şekillendirici jeller ve çözeltiler gibi saç bakım preparatlarında kullanılabilir.
Teknik uygulamaların özeti: Süspansiyonlar, dağıtıcılar ve emülsiyonlar: Sulu süspansiyon, emülsiyon ve dağılımlar PVP K ürünleri eklenerek kararlı hale getirilebilir. Onlar, kendilerinin koagüle olmasını engelleyen koloid partiküllerin yüzeyinde ince bir tabaka olarak emilirler.
Plastik üretimleri: Katı plastik polimerlerin üretiminde , PVP K ürünleri koruyucu kolloidler ve polimerizasyon stabilize edicileri olarak kullanılırlar.
Yapıştırıcılar: K 90 ve K 80, sodyum stearat bazlı yapıştırıcı stiklerde kalınlaştırıcı ve yapıştırıcı olarak kullanılabilirler. Farklı PVP K ürünleri, istenen yoğunlukta yapıştırıcı stikleri vermesi amacıyla harmanlanabilir. Yapıştırıcı dağılımlarda PVP K ürünleri, koruyucu kolloidler ve kalınlaştırıcı ajanlar olarak kullanılırlar. PVP K ürünleri suda kolayca çözünebildiği gibi, posta pulları, zarflar vs... için ıslatıcı reçinelerde kullanılabilir.
Boyalar: K 30 ve K 90 emülsiyon boyalar ve dispersiyon kaplamalarında koruyucu kolloidler ve dağıtıcı olarak kullanılırlar ve dağılımların reolojisini etkilerler.
Kağıt yapımı: Suda hızlı çözünmesi nedeniyle kağıt kaplamada kullanılırlar. (eğer bir sonraki adımda kağıdı tekrar ıslatmak tasarlanmıyorsa).Kağıdı kıvrılmaktan alıkoyar ve pürüzsüz, düzgün bir yüzey sağlar.
Çamaşır deterjanları: Bir katkı olarak, yıkama sıvılarının kir (leke) kapasitesini artırır. Ve boyaların tekrar tortu bırakmasını engeller. Enzimlerin üretiminde tozu bastırmak için, enzimler için bir kaplayıcı olarak kullanılabilirler.
Cam elyafı: K 90 elyafın yüzeyini düzeltmek için haşıl preparatlarında bir komponent olarak kullanılırlar.
Baskı ve diğer mürekkepler: İstenen viskositeyi elde etmek için kullanılabilir.
Seramikler: K 90, kolay işlenemeyen killer için bir bağlayıcı olarak kullanılabilir. Diğer bağlayıcılara göre avantajı, ateşleme sırasında tamamen yanmaya devam etmesi ve bu nedenle seramik kütlesini etkilememesi. Bu özellikle Na iyonlarını içermeyen elektriksel yalıtkanların üretiminde önemlidir. PVP K 90, ayrıca yanmaz pervazların gücünü artırır.
Tabletleme yardımcıları: PVP K 30, ilaca ait olmayan (dişçiliğe ait temizleme tabletleri veya boya ve boya kutularının tabletleri gibi) amaçlar için kullanılan tabletlerin tamamı için bir bağlayıcı olarak kullanılır.
Fotoğraf filmleri: PVP K 30, koruyucu kolloid ve yapışma tetikçisi olarak fotoğraf filmlerinin üretiminde kullanılabilir. K 17, fotoğraf kağıdında bir bağlayıcı olarak kullanılır.
Böcek ilaçlarında: K 90, böcek ilacı dağılımlarında bir dağıtıcı olarak kullanılır ve aktif maddenin bitkiye yapışmasını iyileştirir.
Yapıştırıcı bandajların hazırlanması: K 30 ve K 90 kullanımı kolay plaster bandajları için bir bağlayıcı olarak kullanılabilir. Bandaja, PVP K 30 ve K 90 ilavesi içeren bir metanoik süspansiyon olarak uygulanır ve sonradan kurutulur.
Not: İlaç preparatlarında kullanıma uygun değildir.
Ek bilgi: Film yapıcı ve kalınlaştırıcı olarak kullanılır.Farklı molekül ağırlıklı vinil prolidon homopolimerleridir. Moleküler ağırlık PVP nin setting özelliklerini belirler. Moleküler ağırlık ne kadar yüksekse, setting'de o kadar büyük olur. Jel tipi uyuglamalarda Carbomer tipi kalınlaştırıcı ve diğer karşıt bağlı poliakrilatlarla uyumludur. Bitmiş ürünlerde yüksek saflık istenen su bazlı uygulamalarda kullanım için idealdir.Özellikle ıslak görünüm jelleri saç kremleri, pompalı spreyler ve sıvı saç şekillendirme (setting) preparatlarında normalden-sert'e kadar bir tutuş sağlar. PVP K 30 Toz, saç bakımı ürünleri (şekillendirme jel ve solüsyonlar gibi) üretiminde kullanılabilir. Saç jeli formülasyonunun yanı sıra, PVP K 30 düşük viskositenin önem taşıdığı pompalı spreylerde kullanılır. K 80 ve K 90 saç jelleri ve kremleri gibi yüksek tutuşlu ve yüksek viskositeli ürünler içindir.

Polyvinylpyrrolidone (PVP K-30)

Polyvinylpyrrolidone PVP is one of the three major pharmaceutical new excipients and can be used as the co-solvent of tablets, granules, and injection, as the glidant of capsules, as the dispersant agent of liquid preparations and the colorant, as the stabilizer of enzyme and heat sensitive drug, as the co-precipitating agent of poorly soluble drugs, and as the detoxicant of ophthalmic drugs and lubricants.
It is industrially used as expanded polystyrene additive, as the gelling agents for suspension polymerization, stabilizer, and fiber treating agents, paper processing aids, adhesives, and thickening agents.
Polyvinylpyrrolidone PVP and its copolymers CAP is an important raw material of cosmetics, mainly used for hair retaining agent. The film it formed in the hair is elastic and shiny, and has excellent carding property as well as being free of dust. Adopting different category of resin can meet various kinds of relative humidity climatic conditions. Therefore, it is an indispensable raw material in styling hair cream, hair gel, and mousse. It can also be used for the cosmetics of skin moisturizing agents and the dispersants for grease based hair dying, also as foam stabilizers, and can improve the consistency of the shampoo.Insoluble PVP is the stabilizer of beer and juice which can improve its transparency, color, and flavor.

General PVP (PVP K-30) Properties;
Linear nonionic polymer
• High polarity/proton acceptor
• Amphiphilic
• Compatible with a variety of resins and electrolytes
• Soluble in water and polar solvents, insoluble in esters,ethers, ketones and hydrocarbons
• Unsuitable for thermoplastic processing
• Hard, glossy, transparent, oxygen permeable films which
adhere to a variety of substrates
• Hygroscopic
• Adhesive and cohesive properties
• Cross-linkable
• Physiologically inert

Commercial Types of PVP (PVP K-30)
PVP polymers are available in several viscosity grades, ranging from low to high molecular weight. This range, coupled with solubility in aqueous and organic solvent systems combined with its non-toxic character, gives PVP great flexibility. Its industrial applications include, for example, in adhesives to improve strength and toughness; in paper manufacture to increase strength and as a coating resin; and in synthetic fibers to improve dye receptivity. It is also widely employed in inks, imaging, lithography, detergents and soaps, the textile, ceramic, electrical, metallurgical industries and as a polymerization additive. PVP polymer is supplied in five viscosity grades as a powder and/or aqueous solution. Ashland also offers
pharmaceutical grades of PVP; our PlasdoneTM polymer and PolyplasdoneTM polymer products are used in the pharmaceutical industry, and our PolyclarTM stabilizers are used in the beverage industry.
Chemical and Physical Properties of Polyvinylpyrrolidone (PVP K-30)

Molecular Weight:111.144 g/mol
Odor:ODORLESS
Appearance:White powder. Compatible with a wide range of hydrophilic and hydrophobic resins.
Color: Faintly yellow solid
Melting point ~165 °C (dec.)(lit.)
Boiling Point:90-93 deg C
density :1,69 g/cm3
Water Solubility :Soluble in water.
Sensitive :Hygroscopic
Stability:Stable. Incompatible with strong oxidizing agents. Light sensitive. Hygroscopic.
Specific Gravity: 1.1 - 1.3
pH: 3.0 - 7.0 (1:20 solution)
The use of polyvinylpyrrolidone (PVP K-30)

In the early 1950s, older, with shellac and oil-based hairspray had been rapidly replaced by PVP sprays which are still widely used until now. It can form wet, transparent film on the hair which is shiny and has good lubrication effect. PVP has good compatibility with a variety of good propellant and also has corrosion resistance. It is widely used in hair styling, as the film former in combing products, as the creatinine and stabilizer of skin care lotions and creams, as the base stock material for eye and facial cosmetics and lipstick base, and also as hair dye dispersants and shampoo foam stabilizer. PVP has detoxification effect and can reduce the irritation effects of other preparation on the skin and eyes. It is also used as toothpaste detergents, gelling agents and antidotes. The main drawback of PVP is its sensitivity to moisture. However, this issue can be tackled by using its vinyl acetate copolymer in order to mitigate the effects of moisture and humidity. In addition, PVP also has wide application in the pharmaceutical, beverage and textile industries.

Industrial Applications of Polyvinylpyrrolidone (PVP K-30)

Polyvinylpyrrolidone is widely used in a broad variety of industries. This is due to its unique physical and chemical properties, particularly because of its good solubility in both water and many organic solvents, its chemical stability, its affinity to complex both hydrophobic and hydrophilic substances and its nontoxic character.
Applications and specifications: Used for various applications in cosmetics. They are used in cosmetics as thickening agents, emulsifiers, lubricants and binders. It is suitable to be added to cosmetic products that increase the appearance of the cleaner, paint or skin and hair. PVP K 30 powder and PVP K 90 powder can be used in formulations for both oily and non-oil based creams. PVP K 30 acts as a stiffening agent in hair styling preparations and adjusts the consistency of shampoos, hair dyes and similar preparations. PVP K 30 powder can be added to shampoo and household detergents to protect the skin. Unlike anionic colloids, PVP K grades, such as basic dyes and cationic materials, can be combined, although PVP K 30 powder should be included in the calculations to tack paint. PVP K 30 Powder can be used in hair care preparations such as styling gels and solubilizers.
Summary of technical applications: Suspensions, dispersants and emulsions: Aqueous suspensions, emulsions and dispersions can be stabilized by adding PVP K products. They are absorbed as a thin layer on the surface of colloidal particles, which prevents them from coagulating.

Main Uses of Polyvinylpyrrolidone (PVP K-30)
Summary of technical applications: Suspensions, dispersants and emulsions: Aqueous suspensions, emulsions and dispersions can be stabilized by adding PVP K products. They are absorbed as a thin layer on the surface of colloidal particles, which prevents them from coagulating.

• Protective Colloid and Suspending Agent
• Dye-Receptive Resin
• Binder and Stabilizer
• Adhesive
• Complexing Agent
• Physiologically Inert
•Plastics productions: In the production of solid plastic polymers, PVP K products are used as protective colloids and polymerisation stabilizers.
•Paints: K 30 and K 90 are used as protective colloids and dispersants in emulsion paints and dispersion coatings and affect the rheology of the dispersions.
Paper making: They are used in paper coating because of their rapid dissolution in water. (If it is not intended to rewet the paper in the next step). The paper retains the curl and provides a smooth, smooth surface.
•Laundry detergents
•Fiberglass
•Ceramics
•Tablet assistants: PVP K 30 is used as a binder for all of the tablets used for purposes not previously owned (such as dental cleansing tablets or paint and paint box tablets).
•Photographic films: PVP K 30 can be used in the production of photographic films as protective colloid and adhesion promoter.
•In insecticides
•Preparation of adhesive bandages: K 30 and K 90 can be used as a binder for easy to use plaster bandages. The bandage is applied as a methanoic suspension containing the PVP K 30 and K 90 additions and is subsequently dried.
Potential Health Effects of Polyvinylpyrrolidone (PVP K-30)

Inhalation: May cause irritation to the respiratory tract. Symptoms may include coughing, sore throat, labored breathing, and chest pain.
Ingestion: May cause irritation to the gastrointestinal tract. Symptoms may include nausea, vomiting and diarrhea.
Skin Contact: May cause irritation with redness and pain.
Eye Contact: May cause irritation, redness and pain.
Chronic Exposure: No information found.

Polivinilpirolidon (PVP K-30)

Polivinilpirolidon PVP, üç önemli farmasötik yeni eksipiyanstan biridir ve sıvı preparatların dispersan ajanı ve renk verici olarak kapsüllerin kayganlaştırıcısı olarak tabletlerin, granüllerin ve enjeksiyonun ortak çözücüsü olarak enzim stabilizatörü olarak kullanılabilir ve ısıya karşı hassas ilacı, zayıf çözünür ilaçların birlikte çökeltici ajanı olarak ve oftalmik ilaçların ve yağlayıcıların detoksifiye edicileri olarak içerir.
Süspansiyon polimerizasyonu, stabilizatör ve elyaf işleme maddeleri, kağıt işleme yardımcıları, yapıştırıcılar ve koyulaştırma maddeleri için jelleştirici ajanlar olarak endüstriyel olarak genleştirilmiş polistren katkısı olarak kullanılır.
Polivinilpirolidon PVP ve kopolimerleri CAP, saç tutma ajanı için ağırlıklı olarak kullanılan kozmetikte önemli bir hammaddedir. Saçta oluşturduğu film, elastik ve parlaktır ve mükemmel bir taraklama özelliğine sahiptir ve tozdan arındırılmıştır. Farklı reçine kategorilerini benimsemek, çeşitli bağıl nem iklim koşullarını karşılayabilir. Bu nedenle, saç kremi, saç jeli ve köpük oluşturmak için vazgeçilmez bir hammaddedir. Aynı zamanda cilt nemlendirici ajanlar ve yağ bazlı saç boyama için dispersanlar için köpük stabilizatörleri olarak da kullanılabilir ve şampuanın tutarlılığını artırabilir. Çözünmez PVP, şeffaflığını artırabilen bira ve meyve suyunun stabilizatörüdür, renk ve lezzet.

Genel PVP (PVP K-30) Özellikleri;
Lineer noniyonik polimer
• Yüksek polarite / proton alıcısı
• Amfifilik
• Çeşitli reçine ve elektrolitler ile uyumludur.
• Suda ve polar çözücülerde, esterlerde çözünmeyen, eterler, ketonlar ve hidrokarbonlar
• Termoplastik işleme için uygun değil
• Sert, parlak, şeffaf, oksijen geçiren filmler;
çeşitli yüzeylere yapışır
• Higroskopik
• Yapışkan ve yapışkan özellikler
• Çapraz bağlanabilir
• Fizyolojik olarak inert

Ticari PVP Türleri (PVP K-30)
PVP polimerler, düşük molekül ağırlığından yüksek molekül ağırlığına kadar çeşitli viskozite derecelerinde mevcuttur. Bu aralık, sulu ve organik çözücü sistemlerde çözünürlük ile toksik olmayan karakteriyle birleşince, PVP`ye büyük esneklik kazandırır. Endüstriyel uygulamaları arasında örneğin kuvvet ve tokluğun arttırılması için yapışkanlar; Kâğıt üretiminde mukavemeti artırmak için ve kaplama reçinesi olarak; ve sentetik elyaflarda boya duyarlılığını arttırır. Aynı zamanda mürekkepler, görüntüleme, litografi, deterjan ve sabunlar, tekstil, seramik, elektrik, metalürjik endüstrilerde ve polimerizasyon katkı maddesi olarak yaygın şekilde kullanılmaktadır. PVP polimeri bir toz ve / veya sulu çözelti olarak beş viskozite derecesinde sağlanır. Ashland da sunuyor
ilaç sınıfı PVP; PlasdoneTM polimer ve PolyplasdoneTM polimer ürünleri ilaç endüstrisinde kullanılmakta ve PolyclarTM stabilizatörler içecek endüstrisinde kullanılmaktadır.
Polivinilpirolidonun (PVP K-30) Kimyasal ve Fiziksel Özellikleri

Moleküler Ağırlık: 111.144 g / mol
Koku: kokusuz
Görünüş: Beyaz toz. Çok çeşitli hidrofobik ve hidrofobik reçineler ile uyumludur.
Renk: Hafif sarı katı
Erime noktası ~ 165 ° C (dec.) (Lit.)
Kaynama noktası: 90-93 derece C
yoğunluk: 1,69 g / cm3
Suda Çözünürlük: Suda özünebilir.
Hassas: Higroskopik
Kararlılık: Kararlı. Güçlü oksitleyici ajanlarla uyuşmaz. Işık duyarlı. Higroskopik.
Özgül Ağırlık: 1.1 - 1.3
pH: 3.0 - 7.0 (1:20 çözelti)

Polivinilpirolidon (PVP K-30)
1950`lerin başında, daha eski, şelaklı ve yağ bazlı saç spreyiyle hızla şimdiye kadar yaygın olarak kullanılan PVP spreyleri getirildi. Parlak olan ve iyi bir yağlama etkisi olan ıslak ve şeffaf bir film oluşturabilir. PVP, iyi itici gaz çeşitleriyle iyi uyumluluk gösterir ve ayrıca korozyon direncine sahiptir. Saç şekillendirmesinde yaygın olarak kullanılır; tarama ürünlerinde, cilt bakım losyonları ve kremlerin kreatinin ve dengeleyici olarak, göz ve yüz kozmetiği ve ruj tabanı için temel stok malzemesi olarak ve aynı zamanda saç boya dispersanları ve şampuan köpük dengeleyici. PVP`nin detoksifikasyon etkisi vardır ve diğer preparatların cilt ve gözler üzerindeki tahriş etkilerini azaltabilir. Ayrıca diş macunu deterjanları, jelleştirici maddeler ve panzehir olarak kullanılır. PVP`nin temel dezavantajı, neme duyarlı olmasıdır. Bununla birlikte, bu sorun, nem ve nem etkilerini azaltmak için vinil asetat kopolimerini kullanarak ele alınabilir. Buna ek olarak, PVP, aynı zamanda ilaç, içecek ve tekstil endüstrisinde geniş bir uygulama alanına sahiptir.

Polivinilpirolidonun (PVP K-30) Endüstriyel Uygulamaları

Polivinilpirolidon, geniş çapta endüstrilerde yaygın olarak kullanılmaktadır. Bunun nedeni, özellikle hem suda hem de birçok organik solventte iyi çözünürlüğü, kimyasal stabilitesi, hem hidrofobik hem hidrofilik maddeler kompleksine olan afinitesi ve toksik olmayan karakteri nedeniyle eşsiz fiziksel ve kimyasal özelliklerinden dolayıdır.
Uygulamalar ve özellikler: Kozmetikteki çeşitli uygulamalar için kullanılır. Kozmetikte koyulaştırma maddeleri, emülgatörler, yağlayıcılar ve bağlayıcılar olarak kullanılırlar. Temizleyici, boya veya cilt ve saç görünümünü artıran kozmetik ürünlere eklenmek uygundur. PVP K 30 tozu ve PVP K 90 tozu hem yağlı hem de yağ bazlı kremler için formülasyonlarda kullanılabilir. PVP K 30, saç şekillendirici preparatlarda sertleştirici bir ajan olarak görev yapar ve şampuanlar, saç boyaları ve benzeri müstahzarların tutarlılığını ayarlar. Cildi korumak için şampuan ve evde kullanılan deterjanlara PVP K 30 tozu eklenebilir. Anyonik kolloidlerden farklı olarak bazik boyalar ve katyonik malzemeler gibi PVP K kaliteleri kombine edilebilir, ancak PVP K 30 tozu boya yapıştırmak için hesaplamalara dahil edilmelidir. PVP K 30 Toz, saç şekillendirme jöleleri ve çözünürleştiriciler gibi saç bakımı müstahzarlarında kullanılabilir.
Teknik uygulamaların özeti: Süspansiyonlar, dispersanlar ve emülsiyonlar: Sulu süspansiyonlar, emülsiyonlar ve dispersiyonlar PVP K ürünleri eklenerek stabilize edilebilir. Koloidal parçacıkların yüzeyinde pıhtılaşmayı önleyen ince bir katman olarak emilirler.

Polivinilpirolidonun (PVP K-30) Temel Kullanımları
Teknik uygulamaların özeti: Süspansiyonlar, dispersanlar ve emülsiyonlar: Sulu süspansiyonlar, emülsiyonlar ve dispersiyonlar PVP K ürünleri eklenerek stabilize edilebilir. Koloidal parçacıkların yüzeyinde pıhtılaşmayı önleyen ince bir katman olarak emilirler.

• Koruyucu Koloid ve Askıdaki Ajan
• Boya Alıcı Reçinesi
• Bağlayıcı ve Stabilizatör
• Yapışkan
• Karmaşıklaştırıcı Ajan
• Fizyolojik Olarak İnert
• Plastikler: Katı plastik polimerlerin üretiminde PVP K ürünleri, koruyucu kolloidler ve polimerizasyon stabilizatörleri olarak kullanılırlar.
• Boyalar: K 30 ve K 90, emülsiyon boyalarında ve dispersiyon kaplamalarda koruyucu kolloidler ve dispersanlar olarak kullanılır ve dispersiyonların reolojisini etkiler.
Kağıt yapma: Suda hızla çözünmeleri nedeniyle kağıt kaplamada kullanılırlar. (Kağıdı bir sonraki adımda yeniden ıslatmaya yönelik değilse). Kağıt kıvırmayı korur ve pürüzsüz düz bir yüzey sağlar.
• Çamaşır deterjanları
•Fiberglas
• Seramik
• Tablet asistanları: PVP K 30, daha önce sahibi olmayan amaçlar için kullanılan tüm tabletlerin (diş temizleme tabletleri veya boya ve boya kutusu tabletleri gibi) bir bağlayıcı olarak kullanılır.
• Fotografik filmler: PVP K 30, koruyucu kolloid ve yapışma arttırıcı olarak fotografik filmlerin üretiminde kullanılabilir.
• Böcek ilaçlarında
• Yapışkan bandajların hazırlanması: K 30 ve K 90 alçı bandajların kullanımı kolay bir cilttir. Bandaj, PVP K 30 ve K 90 ilavelerini içeren bir metanoik süspansiyon halinde uygulanır ve daha sonra kurutulur.
Polivinilpirolidonun (PVP K-30) Potansiyel Sağlık Etkileri

Soluma: Solunum sisteminde tahrişe neden olabilir. Belirtiler öksürük, boğaz ağrısı, emzik nefes alma ve göğüs ağrısı içerebilir.
Sindirim sistemi: Gastrointestinal sistemde tahrişe neden olabilir. Belirtiler bulantı, kusma ve diyare içerebilir.
Deri ile temas: Kızarma ve ağrı ile tahrişe neden olabilir.
Gözle Temas: İrritasyon, kızarıklık ve ağrıya neden olabilir.
Kronik Pozlama: Bilginize ulaşamadı.

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