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LAURİL AMİN OKSİT (LAURYL AMINE OXIDE)

LAURYL AMINE OXIDE (LAURİL AMİN OKSİT)

SYNONYMS: lauryl amine oxide; laurylamineoxide; lauryl amineoxide; lauril amin oksit; laurilamin oksit; lauril amin oksit; lauril amine oxit; lauril amin oksid; lauril; lauryl; LAURYL AMİNE OXİDE; LAURYLAMİNEOXİDE; LAURYLAMINEOXIDE; LAURYL AMİNEOXİDE; LAURYL AMINEOXIDE; LAURİL AMİN OKSİT; LAURİL AMİNE OKSİT; LAURİL AMİNE OXİT; LAURİL AMİN OKSİD; LAURYL; LAUR amine oxide, dodecyl(dimethyl)-;ammonyx AO; ammonyx LO; amonyx AO; amyx LO; aromox DM 12D; barlox 12i; N,N-dimethyl dodecyl amine N-oxide; N,N- dimethyl-1-dodecanamine N-oxide; N,N- dimethyl-1-dodecanamine-N-oxide; N,N-dimethyl-1-dodecylamine N-oxide; dimethyl-N-dodecylamine oxide; dimethylaurylamine oxide; N,N- dimethyldodecan-1-amine oxide; dimethyldodecylamine N-oxide; N,N- dimethyldodecylamine N-oxide; dimethyldodecylamine oxide; N,N-; dimethyldodecylamine oxide; N,N- dimethyldodecylamine-N-oxide;dimethyllaurylamine oxide; 1- dodecanamine, N,N-dimethl-, N-oxide; 1- dodecanamine, N,N-dimethyl-,; N-oxide; 1- dodecanamine, N,N-dimethyl-, N-oxide (9CI); dodecycldimethylamine oxide; dodecyl dimethyl amine oxide; N- dodecyl-N,N-dimethylamine oxide; ; dodecyl(dimethyl)amine oxide; dodecylamine, N,N-dimethyl-, N-oxide; dodecyldimethylamine N-oxide; dodecyldimethylamine oxide; N- dodecyldimethylamine oxideN- dodecyldimethylamine oxide.; emcol L; empigen OB; etoxi AC-91; genaminox LA; incromine oxide I; laurelox 12; lauryl dimethyl amine oxide; lauryl dimethylamine-N-oxide; N- lauryl-N,N-dimethylamine oxide; lauryldimethylamine N-oxide; N- lauryldimethylamine N-oxide; lauryldimethylamine oxide; rewominox L 408; rhodamox L; schercamox DML; softamine L; tomah AO 728; unisafe A-LM; Lauryl Amine Oxide (LAO); 1643-20-5; Lauramine oxide; Lauryldimethylamine oxide; Lauryldimethylamine N-oxide; Dodecyldimethylamine oxide; LDAO; Ammonyx AO; Ammonyx LO; Empigen OB; Aromox DMCD; Conco XAL; Dimethyldodecylamine oxide; 1-Dodecanamine, N,N-dimethyl-, N-oxide; Dimethylaurylamine oxide; DDNO; n-Dodecyldimethylamine oxide; Dimethyldodecylamine N-oxide; dodecyl(dimethyl)amine oxide; Dodecyldimethylamine N-oxide; N,N-dimethyldodecan-1-amine oxide; LAURYL DIMETHYLAMINE-N-OXIDE; Aromox dmmc-W; Dimethyllaurylamine oxide; Amonyx AO; Refan [Russian]; lauryl dimethylamine oxide; N,N-Dimethyldodecylamine N-oxide; N,N-Dimethyldodecylamine-N-oxide; N,N-Dimethyl-1-dodecylamine N-oxide; N,N-Dimethyldodecylamine oxide; UNII-4F6FC4MI8W; N-Lauryldimethylamine N-oxide; HSDB 5451; N-Lauryl-N,N-dimethylamine oxide; NCI-C55129; EINECS 216-700-6; MFCD00002049; N,N-Dimethyl-dodecylaminoxid [Czech]; Oxyde de dimethyllaurylamine [French]; Dodecylamine, N,N-dimethyl-, N-oxide; Lauryl dimethyl amine oxide; BRN 1769927; 4F6FC4MI8W; 1-Dodecanamine, N,N-dimethl-, N-oxide; amine oxide, dodecyl(dimethyl)-; CHEMBL1233973; N,N-Dimethyl-1-dodecanamine-N-oxide; N,N-Dimethyldodecylamine N-oxide, 30% solution in water; Refan; Oxyde de dimethyllaurylamine; N,N-Dimethyl-dodecylaminoxid; C14H31NO; Cyclomox L; Rhodamox L; Softamine L; Genaminox LA; Laurylamine oxide; Schercamox DML; Rhodamox LO; Oxamin LO; Emcol L; Incromine oxide L; Emcol LO; Unisafe A-LM; Amphitol 20N; Barlox 12i; Rewominox L 408; Ammonyx DMCD 40; Admox 12; Aromox DM 12D; Aromox DM 12W; Oxidet DM 20; Aromox DM 12D-W; Emal 20N; imethylauroylamine oxide; Dodecycldimethylamine ox; N,N-DIMETHYL-N-DODECYLAMINE OXIDE; Atlas CD 413; Tomah AO 728; Aromox DM 12DW(C); dodecycldimethylamine oxide; Ammonyx C10 Amine Oxide; EC 216-700-6; AC1L25VX; Dimethyldodecylamine-N-oxide; SCHEMBL27337; 4-04-00-00798 (Beilstein Handbook Reference); KSC496S8J; N,N-dimethyldodecanamine oxide; DTXSID1020514; CTK3J6984; CHEBI:131762; SYELZBGXAIXKHU-UHFFFAOYSA-N; (C10-16)alkyldimethylamine oxide; 101CG; ZINC2039372; BDBM50327308; N,N-dimethyldodecan-1-amine N-oxide; AKOS015904034; DB04147; LS-7353; RP27839; RTR-007066; KS-00000Y19; NCGC00164286-01; AN-20669; N,N-Dimethyldodecylamine-N-oxide solution; SC-68556; SC-80023; Lauryldimethylamine oxide / Lauramine oxide; TR-007066; FT-0689256; V0580; 1-Dodecanamine, N,N-dimethyl-, N-oxide (9CI); LDAO, N,N-dimethyldodecylamine N-oxide, powder; Dodecylamine, N,N-dimethyl-, N-oxide (6CI,8CI); N,N-Dimethyldodecylamine N-oxide 100 mM solution; J-010130; J-521637; I14-18380; N,N-Dimethyldodecylamine N-oxide 30% Solution in H2O; N,N-Dimethyldodecylamine N-oxide, >=99% (titration); N,N-Dimethyldodecylamine N-oxide solution, ~30% in H2O; N,N-Dimethyldodecylamine N-oxide, BioXtra, >=99.0% (NT); UNII-LF6BKC321J component SYELZBGXAIXKHU-UHFFFAOYSA-N; UNII-QWA2IZI6FI component SYELZBGXAIXKHU-UHFFFAOYSA-N; N,N-Dimethyldodecylamine N-oxide solution, BioUltra, ~0.1 M in H2O ;1-Dodecanamine,N,N-dimethyloxide; ammonyxao; aromoxdmcd; aromoxdmmc-w; LDAO; lauramine oxide; dodecylamine, N,N-dimethyl-, N-oxide
Lauryl Amine Oxide
Join Prospector for free! Prospector is a specialty search engine where you can: Access 1000's of Technical Documents Evaluate Material Data & Specifications Get Pricing and Technical Assistance Lauryl Amine Oxide CREATE YOUR FREE ACCOUNT Acme Hardesty Co. makes their documentation available in the regions indicated below: Lauryl Amine Oxide (LAO) is a standard liquid surfactant. It appears as a clear yellow liquid. This product is used as a viscosity modifier and foam enhancer for shampoos and shower gels. It is also applied as a foam enhancer and detergent in hard surface cleaners, sanitizing products, dishwashing liquids, and car wash systems. In addition, this product is suitable as a water-based nonionic surfactant compatible with anionic and cationic systems.
COMPANY
Acme Hardesty Co. supplies oleochemicals and castor oil products to the Food, Beverage and Nutrition industry. Products include aluminum distearate, calcium stearate, capric, caproic and caprylic acid, glycerine, distilled palm oil fatty acid, hydrogenated tallow glyceride, lauric acid, magnesium stearate, triglyceride, myristic acid, oleic acid, palmitic acid, propylene glycol USP, sodium stearate, stearic acid. Lauryl Amine OxideChemical Name: Amines Coco Alkyldimethyl N-OxidesCAS#: 1643-20-5 / 61788-90-7 USES & APPLICATIONS Personal Care: Viscosity Modifier and Foam Enhancer for Shampoos and Shower GelsSoaps and Detergents: Foam Enhancer and Detergent in Hard Surface Cleaners, Sanitizing Products, Dishwashing Liquids and Car Wash SystemsSurfactants and Esters: Water Based Nonionic Surfactant Compatible with Anionic and Cationic Systems GRADES AND FORMS AVAILABLE 30% Liquid PACKAGING Drums, Isotanks SHELF LIFE One Year from Date of Manufacture when stored according to MSDS recommendations. INCI NAME Lauramine Oxide LOOKING FOR LARGER QUANTITIES?Get a Quote>< 1 > Sales Specifications of Lauryl Amine Oxide Parameters Specifications Test Methods Appearance Clear Liquid - Odor Characteristic - Color Colorless to Pale Yellow - pH (10% Solution W/V) 5.5 - 7.5 - Assay, % by mass 27 - 29 - Free Amine, % 0.5 max - Microbial Count (Plate Method), cfu/mL < 10 - Molecular Weight 240 - Lauryldimethylamine oxide From Wikipedia, the free encyclopedia Jump to navigationJump to search Lauryldimethylamine oxide Lauryldimethylamine oxide.png Names IUPAC name N,N-Dimethyldodecan-1-amine oxide Other names Lauramine oxide; Dodecyldimethylamine oxide; Dimethyldodecylamine-N-oxide Identifiers CAS Number 1643-20-5 ☑ 3D model (JSmol) Interactive image ChemSpider 14688 ☒ ECHA InfoCard 100.015.183 EC Number 216-700-6 ubChem CID 15433 CompTox Dashboard (EPA) DTXSID1020514 Edit this at Wikidata InChI[show] SMILES[show] Properties Chemical formula C14H31NO Molar mass 229.408 g·mol-1 Appearance White solid Density 0.996 g/ml Boiling point 132-133 °C (270-271 °F; 405-406 K) Surface tension: CMC mM[1][2] Hazards Safety data sheet [3] GHS pictograms GHS05: Corrosive[3] GHS Signal word Danger[3] GHS hazard statements H314[3] GHS precautionary statements P280, P305+351+338, P310[3] Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ☒ verify (what is ☑☒ ?) Infobox references Lauryldimethylamine oxide (LDAO), also known as dodecyldimethylamine oxide (DDAO), is an amine oxide based nonionic surfactant, with a C12 (dodecyl) alkyl tail. It is one of the most frequently-used surfactants of this type.[4] Like other amine oxide based surfactants it is antimicrobial, being effective against common bacteria such as S. aureus and E. coli,[1] however it is also non-denaturing and may be used to solubilize proteins. At high concentrations, LDAO forms liquid crystalline phases.[5] Despite having only one polar atom that is able to interact with water - the oxygen atom (the quaternary nitrogen atom is hidden from intermolecular interactions), DDAO is a strongly hydrophilic surfactant: it forms normal micelles and normal liquid crystalline phases. High hydrophilicity of this surfactant can be explained by the fact that it forms very strong hydrogen bonds with water: the energy of DDAO - water hydrogen bond is about 50 kJ/mol.[6] Lauramine oxide PubChem CID: 15433 Structure: Lauramine oxide_small.png Lauramine oxide_3D_Structure.png Find Similar Structures Chemical Safety: Corrosive Irritant Environmental Hazard Laboratory Chemical Safety Summary (LCSS) Datasheet Molecular Formula: C14H31NO Synonyms: 1643-20-5 Lauramine oxide Lauryldimethylamine oxide Lauryldimethylamine N-oxide Dodecyldimethylamine oxide More... Molecular Weight: 229.4 g/mol Dates: Modify: 2019-10-26 Create: 2005-06-01 Dodecyldimethylamine N-oxide is a tertiary amine oxide resulting from the formal oxidation of the amino group of dodecyldimethylamine. It has a role as a plant metabolite and a detergent. It derives from a hydride of a dodecane. from ChEBI Dimethyldodecylamine-n-oxide is a crystalline solid. from CAMEO Chemicals 1Structures HelpNew Window 1.12D Structure HelpNew Window Find Similar Structures Get Image Download Chemical Structure Depiction Lauramine oxide.png Full screen Zoom in Zoom out rom PubChem 1.23D Conformer HelpNew Window Get Image Download Interactive Chemical Structure Model Ball and Stick Sticks Wire-Frame Space-Filling Show Hydrogens Animate Full screen in Zoom out rom PubChem 1.3Crystal Structures HelpNew Window PDBe Ligand Code LDA PDBe Structure Code 1AIJ PDBe 
More Actions Menu Interactive Chemical Structure Model Ball and StickSticksWire-FrameSpace-Filling Show Hydrogens Animate screen Zoom in Zoom out from Protein Data Bank in Europe (PDBe) 2Names and Identifiers HelpNew Window 2.1Computed Descriptors HelpNew Window 2.1.1IUPAC Name HelpNew Window N,N-dimethyldodecan-1-amine oxide from PubChem 2.1.2InChI HelpNew Window InChI=1S/C14H31NO/c1-4-5-6-7-8-9-10-11-12-13-14-15(2,3)16/h4-14H2,1-3H3 from PubChem 2.1.3InChI Key HelpNew Window SYELZBGXAIXKHU-UHFFFAOYSA-N from PubChem 2.1.4Canonical SMILES HelpNew Window CCCCCCCCCCCC[N+](C)(C)[O-] from PubChem 2.2Molecular Formula HelpNew Window C14H31NO from PubChem 2.3Other Identifiers HelpNew Window 2.3.1CAS HelpNew Window 1643-20-5 from ChemIDplus; EPA Chemicals under the TSCA; EPA DSSTox; European Chemicals Agency (ECHA); HSDB 2.3.1Other CAS HelpNew Window 135526-66-8, 160714-02-3, 163221-07-6, 177162-47-9, 73502-08-6, 209122-49-6, 311814-25-2, 244235-92-5, 607690-42-6, 1616935-99-9 from ChemIDplus 2.3.2European Community (EC) Number HelpNew Window 216-700-6 from European Chemicals Agency (ECHA) 2.3.3UN Number HelpNew Window 3249 from CAMEO Chemicals 2.3.4UNII HelpNew Window 4F6FC4MI8W from FDA/SPL Indexing Data 2.3.5DSSTox Substance ID HelpNew Window DTXSID1020514 from EPA DSSTox 2.3.6Wikipedia HelpNew Window Lauramine oxide from Wikipedia 2.4Synonyms HelpNew Window 2.4.1MeSH Entry Terms HelpNew Window Ammonyx LO DDAO dodecyldimethylamine N-oxide dodecyldimethylamine oxide hexyldimethylamine oxide Lauryldimethylamine oxide LDAO N,N-dimethyldodecyclamine N-oxide N,N-dimethyldodecylamine-N-oxide N-dodecyl-N,N-dimethylamine N-oxide from MeSH
2.4.2Depositor-Supplied Synonyms HelpNew Window
1643-20-5 Lauramine oxide Lauryldimethylamine oxide Lauryldimethylamine N-oxide Dodecyldimethylamine oxide LDAO Ammonyx AO Ammonyx LO Empigen OB Aromox DMCD Conco XAL Dimethyldodecylamine oxide 1-Dodecanamine, N,N-dimethyl-, N-oxide Dimethylaurylamine oxide DDNO n-Dodecyldimethylamine oxide Dimethyldodecylamine N-oxide dodecyl(dimethyl)amine oxide Dodecyldimethylamine N-oxide N,N-dimethyldodecan-1-amine oxide LAURYL DIMETHYLAMINE-N-OXIDE Aromox dmmc-W Dimethyllaurylamine oxide Amonyx AO Refan [Russian] lauryl dimethylamine oxide N,N-Dimethyldodecylamine N-oxide N,N-Dimethyldodecylamine-N-oxide N,N-Dimethyl-1-dodecylamine N-oxide N,N-Dimethyldodecylamine oxide UNII-4F6FC4MI8W N-Lauryldimethylamine N-oxide HSDB 5451 N-Lauryl-N,N-dimethylamine oxide NCI-C55129 EINECS 216-700-6 MFCD00002049 N,N-Dimethyl-dodecylaminoxid [Czech] Oxyde de dimethyllaurylamine [French] Dodecylamine, N,N-dimethyl-, N-oxide Lauryl dimethyl amine oxide BRN 1769927 4F6FC4MI8W 1-Dodecanamine, N,N-dimethl-, N-oxide amine oxide, dodecyl(dimethyl)- CHEMBL1233973 N,N-Dimethyl-1-dodecanamine-N-oxide N,N-Dimethyldodecylamine N-oxide, 30% solution in water Refan Oxyde de dimethyllaurylamine N,N-Dimethyl-dodecylaminoxid C14H31NO Cyclomox L Rhodamox L Softamine L Genaminox LA Laurylamine oxide Schercamox DML Rhodamox LO Oxamin LO Emcol L Incromine oxide L Emcol LO Unisafe A-LM Amphitol 20N Barlox 12i Rewominox L 408 Ammonyx DMCD 40 Admox 12 Aromox DM 12D Aromox DM 12W Oxidet DM 20 Aromox DM 12D-W Emal 20N methylauroylamine oxide Dodecycldimethylamine ox N,N-DIMETHYL-N-DODECYLAMINE OXIDE Atlas CD 413 Tomah AO 728 Aromox DM 12DW(C) dodecycldimethylamine oxide Ammonyx C10 Amine Oxide EC 216-700-6 AC1L25VX Dimethyldodecylamine-N-oxide SCHEMBL27337 4-04-00-00798 (Beilstein Handbook Reference) KSC496S8J N,N-dimethyldodecanamine oxide DTXSID1020514 CTK3J6984 CHEBI:131762 -UHFFFAOYSA-N (C10-16)alkyldimethylamine oxide ZINC2039372 BDBM50327308 N,N-dimethyldodecan-1-amine N-oxide AKOS015904034 DB04147 LS-7353 RP27839 RTR-007066 KS-00000Y19 NCGC00164286-01 AN-20669 N,N-Dimethyldodecylamine-N-oxide solution SC-68556 SC-80023 Lauryldimethylamine oxide / Lauramine oxide TR-007066 FT-0689256 V0580 1-Dodecanamine, N,N-dimethyl-, N-oxide (9CI) LDAO, N,N-dimethyldodecylamine N-oxide, powder Dodecylamine, N,N-dimethyl-, N-oxide (6CI,8CI) N,N-Dimethyldodecylamine N-oxide 100 mM solution J-010130 J-521637 I14-18380 N,N-Dimethyldodecylamine N-oxide 30% Solution in H2O N,N-Dimethyldodecylamine N-oxide, >=99% (titration) N,N-Dimethyldodecylamine N-oxide solution, ~30% in H2O N,N-Dimethyldodecylamine N-oxide, BioXtra, >=99.0% (NT) UNII-LF6BKC321J component SYELZBGXAIXKHU-UHFFFAOYSA-N UNII-QWA2IZI6FI component SYELZBGXAIXKHU-UHFFFAOYSA-N N,N-Dimethyldodecylamine N-oxide solution, BioUltra, ~0.1 M in H2O from PubChem 3Chemical and Physical Properties HelpNew Window 3.1Computed Properties HelpNew Window Property Name Property Value Molecular Weight 229.4 g/mol XLogP3-AA 5.3 Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 1 Rotatable Bond Count 11 Exact Mass 229.240565 g/mol Monoisotopic Mass 229.240565 g/mol Topological Polar Surface Area 18.1 A^2 Heavy Atom Count 16 Formal Charge 0 Complexity 146 Isotope Atom Count 0 Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 Covalently-Bonded Unit Count 1 Compound Is Canonicalized Yes from PubChe 3.2Experimental Properties HelpNew Window 3.2.1Physical Description HelpNew Window
Dimethyldodecylamine-n-oxide is a crystalline solid. from CAMEO Chemicals Liquid from EPA Chemicals under the TSCA 3.2.2Color/Form HelpNew Window Very hygroscopic needles from dry toluene. Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 10th ed. Volumes 1-3 New York, NY: John Wiley & Sons Inc., 1999., p. 1431 from HSDB 3.2.3Melting Point HelpNew Window 266 to 268 °F (NTP, 1992) National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. from CAMEO Chemicals 132.5 °C from EPA DSSTox 130.5 °C
Lide, D.R. CRC Handbook of Chemistry and Physics 86TH Edition 2005-2006. CRC Press, Taylor & Francis, Boca Raton, FL 2005, p. 3-198 from HSDB 3.2.4Solubility HelpNew Window In water, 190,000 mg/L at 25 °C Brown SL et al.; Research Program on Hazard Priority Ranking of Manufactured Chemicals (Chemicals 61-79). NTIS PB-263 164. Menlo Park, CA: Stanford Research Institute (1975) from HSDB 3.2.5Vapor Pressure HelpNew Window 6.2X10-8 mm Hg at 25 °C (est) US EPA; Estimation Program Interface (EPI) Suite. Ver. 3.20. February, 2007. Available from, as of Jun 17, 2008: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm from HSDB 3.2.6Octanol/Water Partition Coefficient HelpNew Window log Kow = 4.67 (est) US EPA; Estimation Program Interface (EPI) Suite. Ver. 3.20. February, 2007. Available from, as of Jun 17, 2008: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm from HSDB 3.2.7Stability/Shelf Life HelpNew Window Stable at high concentrations of electrolytes and over a wide pH range /Monohydrate/ Hawley, G.G. The Condensed Chemical Dictionary. 9th ed. New York: Van Nostrand Reinhold Co., 1977., p. 502 from HSDB 3.2.8Decomposition HelpNew Window When heated to decomposition it emits very toxic fumes of /chloride, ammonium, and nitrogen oxides./ Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 1424 from HSDB 3.2.9Other Experimental Properties HelpNew Window When heated to decomposition it emits toxic fumes of NOx. Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 10th ed. Volumes 1-3 New York, NY: John Wiley & Sons Inc., 1999., p. 1431 from HSDB Law constant = 6.6X10-11 atm-cu m/mole at 25 °C (est) US EPA; Estimation Program Interface (EPI) Suite. Ver. 3.20. February, 2007. Available from, as of Jun 17, 2008: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm from HSDB Hydroxyl radical reaction rate constant = 2.7X10-11 cu cm/molecule-sec at 25 °C (est) US EPA; Estimation Program Interface (EPI) Suite. Ver. 3.20. February, 2007. Available from, as of Jun 17, 2008: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm from HSDB

 

4Spectral Information HelpNew Window 4.11D NMR Spectra HelpNew Window Lauryl Amine Oxide 4.1.11H NMR Spectra HelpNew Window Instrument Name Varian CFT-20 Copyright Copyright © 2009-2018 Bio-Rad Laboratories, Inc. All Rights Reserved. Thumbnail Thumbnail from SpectraBase 4.1.213C NMR Spectra HelpNew Window Source of Sample Fluka AG, Buchs, Switzerland Copyright Copyright © 1980, 1981-2018 Bio-Rad Laboratories, Inc. All Rights Reserved. Thumbnail Thumbnail from SpectraBase 4.2Mass Spectrometry HelpNew Window 4.2.1LC-MS HelpNew Window MoNA ID SM876801 MS Category Experimental MS Type LC-MS MS Level MS2 Precursor Type [M+H]+ precursor m/z 230.2478 Lauryl Amine Oxide Instrument Q Exactive Plus Orbitrap Thermo Scientific Instrument Type LC-ESI-QFT Ionization ESI Ionization Mode positive Collision Energy 35 (nominal) Retention Time 10.848 min Splash splash10-053r-5090000000-aa2a283929dbfc2371fa Thumbnail Submitter CASMI Team, UFZ, Eawag from MassBank of North America (MoNA) 4.3IR Spectra HelpNew Window 4.3.1FTIR Spectra HelpNew Window Technique FILM (CAST FROM CHCl3) Source of Sample Fluka Chemie AG, Buchs, Switzerland Catalog Number 40234 Copyright Copyright © 1980, 1981-2018 Bio-Rad Laboratories, Inc. All Rights Reserved. Thumbnail Thumbnail from SpectraBase 5Related Records HelpNew Window 5.1Related Compounds with Annotation HelpNew Window 162 items View More Rows & Details Download SORT BY Descending Compound CID Structure Compound CID Name Molecular Formula Molecular Weight, g/mol Structure 17388 1-Octadecanamine, N,N-dimethyl-, N-oxide C20H43NO 313.6 Structure 18739 1-Tetradecanamine, N,N-dimethyl-, N-oxide C16H35NO 257.45 Structure 37159 Amines, C10-16-alkyldimethyl, N-oxides C15H33NO 243.43 Structure 62451 Octyldimethylamine oxide C10H23NO 173.3 Structure 62452 N,N-Dimethyldecylamine N-oxide C12H27NO 201.35 1 2 3 ... 33 from PubChem 5.2Related Compounds HelpNew Window Same Connectivity 2 Records Same Parent, Connectivity 12 Records Same Parent, Exact 11 Records Mixtures, Components, and Neutralized Forms 26 Records Similar Compounds 157 Records Similar Conformers 12 Records from PubChem 5.3Substances HelpNew Window 5.3.1Related Substances HelpNew Window Lauryl Amine Oxide All 141 Records Same 100 Records Mixture 41 Records PubChem 5.3.2Substances by Category HelpNew Window 7 Categories Expanded View Download Chemical Vendors (47) Curation Efforts (14) Organizations (12) Journal Publishers (3) NIH Initiatives (1) Research And Development (17) Subscription Services (4) Legacy Depositors (21) from PubChem 5.4Entrez Crosslinks HelpNew Window PubMed 23 Records Protein Structures 1 Record from PubChem 6Chemical Vendors HelpNew Window Showing 1 Substance per Vendor View All View in Entrez Download Tractus PubChem SID: 204365243 Purchasable Chemical: RTR-007066 Alfa Aesar PubChem SID: 376203811 Purchasable Chemical: H26065 AHH Chemical co.,ltd PubChem SID: 381029707 Purchasable Chemical: MR-1000259 Lauryl Amine Oxide Hairui Chemical PubChem SID: 375630063 Purchasable Chemical: HR100678 Sigma-Aldrich PubChem SID: 57649943 Purchasable Chemical: 40231_SIGMA eNovation Chemical PubChem SID: 376045191 Purchasable Chemical: D589017 VladaChem PubChem SID: 329733187 Purchasable Chemical: VL142032 ZINC PubChem SID: 256349602 Purchasable Chemical: ZINC2039372 Alfa Chemistry PubChem SID: 376008977 Purchasable Chemical: 1643-20-5 Biosynth PubChem SID: 332865003 lauryl amine oxide Purchasable Chemical: J-010130 Norris Pharm PubChem SID: 383229894 Purchasable Chemical: NSTH-D32891 (URL not provided...) Finetech Industry Limited PubChem SID: 164779473 Chemical: FT-0689256 LabNetwork, a WuXi AppTec Company PubChem SID: 346706840 Purchasable Chemical: LN00223566 Glentham Life Sciences Ltd. PubChem SID: 310277642 Purchasable Chemical: GC9735 Yuhao Chemical PubChem SID: 347743228 Chemical: LT7397 3B Scientific (Wuhan) Corp PubChem SID: 375087939 Purchasable Chemical: 3B6-00882 labseeker PubChem SID: 253654397 Purchasable Chemical: SC-68556 abcr GmbH PubChem SID: 316440514 Purchasable Chemical: AB206075 lauryl AKos Consulting & Solutions PubChem SID: 152043453 Purchasable Chemical: AKOS015904034 Aurora Chemicals LLC PubChem SID: 310104563 Purchasable Chemical: A17.876.846 ChemTik PubChem SID: 162765302 Purchasable Chemical: CTK3J6984 MolPort PubChem SID: 91695002 Purchasable Chemical: MolPort-003-931-958 PubChem SID: 373567986 Purchasable Chemical: Amb22168367 Boc Sciences PubChem SID: 254768071 Purchasable Chemical: 1643-20-5 Parche SID: 316963698 Purchasable Chemical: 18302 Angene Chemical PubChem SID: 207123664 Lauryl Amine Oxide Purchasable Chemical: AGN-PC-0JKCAJ King Scientific PubChem SID: 346441066 Purchasable Chemical: KS-00000Y19 Innovapharm PubChem SID: 385414823 Purchasable Chemical: BBV-00086369 (URL not provided...) Phion Ltd PubChem SID: 315445645 Purchasable Chemical: 83718550 AA BLOCKS PubChem SID: 381940631 Purchasable Chemical: AA00ILFJ Acadechem SID: 321916803 Purchasable Chemical: ACDS-035290 MuseChem PubChem SID: 355176629 Purchasable Chemical: R022236 AK Scientific, Inc. (AKSCI) PubChem SID: 162187894 Purchasable Chemical: V0580 from PubChem 7Pharmacology and Biochemistry HelpNew Window 7.1MeSH Pharmacological Classification HelpNew Window Surface-Active Agents Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics. (See all compounds classified as Surface-Active Agents.) from MeSH Detergents Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties. (See all compounds classified as Detergents.) from MeSH 7.2Absorption, Distribution and Excretion New Window (1-Dodecyl-14C)lauramine oxide (10 mg with 100 uCi of 14C) was applied to the skin of two humans to study cutaneous absorption and metabolism of lauramine oxide. Ninety-two percent of the applied radioactivity was recovered from the skin of the test subjects 8 hr after dosing, and 0.1 and 0.23% of the radioactivity was recovered from the excretion products of the test subjects. The stratum corneum contained <0.2% of the applied dose. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 231-45 (1994) from HSDB Oral administration of a solution containing 50 mg (1-dodecyl-14C)lauramine oxide (100 uCi of 14C) to two humans resulted in excretion patterns of radioactivity similar to that of the other species studied. Fifty percent and 37% of the radioactivity was found in the urine within 24 hr of dosing, and expired 14C02 contained between 18 and 22% of the radioactivity administered. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 231-45 (1994) from HSDB Four Sprague-Dawley rats were given intraperitoneal injections of 22 mg (methyl-14C)lauramine oxide kg (specific activity 1.3 mCi/g). Sixty-seven percent of the total radioactivity was eliminated in the urine, 8% was expired as I4CO2, and 6% was eliminated in the feces within 24 hr. The distribution of radioactivity was essentially the same as that seen in rats given oral doses of lauramine oxide. The conclusion was that "... microbial metabolism by gastrointestinal flora does not play a major role in the absorption and excretion of [lauramine oxide] in rats." Lauryl Amine Oxide Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 231-45 (1994) from HSDB Aqueous (methyl-14C)lauramine oxide (10 mg containing 1.3 mCi/g) was applied to the skin of four Sprague-Dawley rats to test metabolism and absorption of the compound. Over 72 hr, 14.2% of the total radioactivity was found in the urine, 2.5% in the CO2, and 1.8% in the feces. Radioactivity was detected in the liver, kidneys, testes, blood, and expired CO2. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 231-45 (1994) from HSDB Two groups of four male and one group of four female Sprague-Dawley rats were given 100 mg/kg of (methyl-14C)lauramine oxide (specific activity 1.3 mCi/g) or (1-dodecyl-14C)lauramine oxide (specific activity 1 mCi/g) orally in a metabolic study. There were no significant differences in metabolism or distribution of the compounds between male and female rats. Approximately 75% of the total radioactivity was excreted within 24 hr of oral administration. The rats eliminated 71 and 53% of the administered dose of (methyl-14C)lauramine oxide and (1-dodecyl-14C)lauramine oxide, respectively, in their urine, 13 and 23% as 14CO2, and 12 and 9% in their feces. Over two-thirds of the radioactivity expired as 14CO2 appeared within 12 hr after administration of either dose. The largest concentration of radioactivity in the tissue was found in the liver. Radioactivity was also found in the kidneys, intestine, lungs, spleen, heart, pancreas, bone marrow, leg muscles, testes, ovaries, and whole blood. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 234 (1994) from HSDB An oral or cutaneous dose of N,N-dimethyl dodecylamine N-oxide was rapidly absorbed and metabolized by rats. The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 5: A Review of the Literature Published during 1976 and 1977. London: The Chemical Society, 1979., p. 501 from HSDB Oral dose is rapidly absorbed and excreted by rats and man. Peak tissue levels in rats occur within 1 hr. Cutaneously administered it is absorbed by man, rats, rabbits and mice. Rate of absorption in man through skin is less than in animals. PMID:854921 Rice DP; Toxicol Appl Pharmacol 39 (3): 377 (1977) from HSDB 7.3 Metabolism/Metabolites HelpNew Window Metabolic profiles for different species (rat, human, mouse, rabbit) did not have any significant differences in metabolites, but the degree of absorption, especially in cutaneous applications, varied from species to species. Lauryl Amine Oxide Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 231-45 (1994) from HSDB
Characterization of metabolites of lauramine oxide resulted in the positive identification of only one metabolite, N-dimethyl-4-aminobutyric acid N-oxide. Several pathways exist for metabolism of lauramine oxide: omega,beta-oxidation of alkyl chains (the most common pathway for surfactant metabolism), hydroxylation of alkyl chains, and reduction of the amine oxide group.
Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 231-45 (1994) from HSDB Urinary metabolites in rats, rabbits and humans suggested metabolism via omega, beta-oxidation of the aliphatic chain, amine oxide reduction and aliphatic, mid-chain hydroxylation. N,N-dimethyl-4-aminobutyric acid and its N-oxide accounted for 28, 28 and 23% in man, rats and rabbits, respectively. PMID:7293233 Turan et al; Xenobiotica 11 (7): 447 (1981) from HSDB 8Use and Manufacturing HelpNew Window 8.1Use Classification HelpNew Window EPA Safer Chemical Functional Use Classes Surfactants Safer Chemical Classes Green circle Green circle - The chemical has been verified to be of low concern from EPA Safer Choice 8.2Uses HelpNew Window EPA CPDat Chemical and Product Categories 56 items View More Download SORT BY Descending Category Category Description Categorization Type Agricultural Relating to agricultural, including the raising and farming of animals and growing of crops CPCat Cassette Air_fresheners, fragrance, consumer_use Term applied when the only information the source indicates is 'consumer' or 'consumer product' ; also applied to terms that the source indicates are for consumer use, yet the descriptor term is ambivalent about usage (e.g., cleaning_washing products may be for industrial or consumer use, when the source indicates consumer use, the consumer_use term is also applied) - see appendix for full list of unambiguous consumer related terms plus ambiguous consumer related terms which if indicated are labeled with 'consumer_use' CPCat Cassette Anticondensation Agents to prevent condensation, or condensation removers CPCat Cassette Automotive_care Relatived to the maintenance and repair of automobiles, products for cleaning and caring for automobiles (auto shampoo, polish/wax, undercarriage treatment, brake grease) CPCat Cassette Automotive_care, consumer_use Term applied when the only information the source indicates is 'consumer' or 'consumer product' ; also applied to terms that the source indicates are for consumer use, yet the descriptor term is ambivalent about usage Lauryl Amine Oxide (e.g., cleaning_washing products may be for industrial or consumer use, when the source indicates consumer use, the consumer_use term is also applied) - see appendix for full list of unambiguous consumer related terms plus ambiguous consumer related terms which if indicated are labeled with 'consumer_use' CPCat Cassette Next The Chemical and Products Database, a resource for exposure-relevant data on chemicals in consumer products, Scientific Data, volume 5, Article number: 180125 (2018), DOI:10.1038/sdata.2018.125 from EPA Chemical and Products Database (CPDat) As a foam stabilizer; stable at high concentration of electrolytes and over a wide pH range. Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 742 from HSDB Lauramine oxide and stearamine oxide are aliphatic tertiary amine oxides that are used in cosmetics as foam builders and stabilizers, viscosity enhancers, emollients, conditioners, emulsifiers, antistatic agents, and wetting agents. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13(3):231-45 (1994) from HSDB Surfactant amine oxides such as lauryldimethylamine oxide are ... widely used as constituents of dishwasher detergents, shampoos, and soaps. Kosswig K; Ullmann's Encyclopedia of Industrial Chemistry. 7th ed. (2008). NY, NY: John Wiley & Sons; Surfactants. Online Posting Date: June 15, 2000. from HSDB ... Used to modify foaming and also may find application as hair conditioning agents in shampoos, ie, acting as antistatic agents to provide manageability. Pohl S et al; Kirk-Othmer Encyclopedia of Chemical Technology. (2001). NY, NY: John Wiley & Sons; Hair Preparations. Online Posting Date: December 4, 2000. from HSDB /In antiaging agents,/ containing composition for the activation of corneum protease activity resulting in higher turnover and repair rates of the stratum corneum. Cottam HB; Kirk-Othmer Encyclopedia of Chemical Technology. (2001). NY, NY: John Wiley & Sons; Antiaging Agents. Online Posting Date: November 14, 2003. from HSDB A nonionic detergent. /Used/ as a foam stabilizer /Monohydrate/ Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 14th Edition. John Wiley & Sons, Inc. New York, NY 2001., p. 1431 from HSDB Foam boosters/stabilizers (liquid, powder detergents, shampoos); antistatic agent (textile spin finishes) Ashford, R.D. Ashford's Dictionary of Industrial Chemicals. London, England: Wavelength Publications Ltd., 1994., p. 331 from HSDB ANTIFUNGAL & ANTIBACTERIAL FOR COSMETICS, EG, TOOTHPASTE SRIfrom HSDB 8.2.1Industry Uses HelpNew Window Agricultural chemicals (non-pesticidal) Pesticide Formulation active agents https://www.epa.gov/chemical-data-reporting from EPA Chemicals under the TSCA 8.2.2Consumer Uses HelpNew Window Agricultural products (non-pesticidal) Cleaning and furnishing care products Laundry and dishwashing products Non-TSCA use Personal care products https://www.epa.gov/chemical-data-reporting Lauryl Amine Oxide from EPA Chemicals under the TSCA 8.3Methods of Manufacturing HelpNew Window REACTION OF DIMETHYL-N-DODECYLAMINE WITH HYDROGEN PEROXIDE SRI from HSDB 8.4U.S. Production HelpNew Window Aggregated Product Volume (EPA CDR 2016) 10,000,000 - 50,000,000 lb https://www.epa.gov/chemical-data-reporting from EPA Chemicals under the TSCA (1979) PROBABLY GREATER THAN 4.54X10+6 GRAMS LAURYL AMINE OXIDE SRI from HSDB (1981) 2.7X10+10 G (ESTIMATED) SRI from HSDB Production volumes for non-confidential chemicals reported under the Inventory Update Rule. Table: Year Production Range (pounds) 1986 >1 million - 10 million 1990 >1 million - 10 million 1994 >1 million - 10 million 1998 >1 million - 10 million 2002 >1 million - 10 million US EPA; Non-confidential Production Volume Information Submitted by Companies for Chemicals Under the 1986-2002 Inventory Update Rule (IUR). 1-Dodecanamine, N,N-dimethyl-, N-oxide (1643-20-5). Available from, as of July 9, 2008: http://www.epa.gov/oppt/iur/tools/data/2002-vol.html

 

 

1-Dodecanamine, N,N-dimethyl-, N-oxide is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438). EPA/Office of Pollution Prevention and Toxics; High Production Volume (HPV) Challenge Program. Available from the Database Query page at: http://www.epa.gov/hpv/pubs/general/opptsrch.htm on 1-Dodecanamine, N,N-dimethyl-, N-oxide (1643-20-5) as of July 9, 2008 from HSDB
8.5U.S. Imports HelpNew Window (1979) No Data SRI from HSDB (1981) No Data SRI from HSDB 8.6U.S. Exports HelpNew Window (1979) No Data

 

8.7Manufacturers HelpNew Window Noveon, Inc., 9911 Brecksville Road, Cleveland, OH 44141, (216) 447-5000; Production site: Clifton, NJ 07012 SRI Consulting. 2007 Directory of Chemical Producers United States. Menlo Park, CA 2007, p. 699 from HSDB Stepan Company, 22 West Frontage Road, Northfield, IL 60093, (847) 446-7500, (800) 745-7837 (Technical service), (800) 457-7673 (Customer service); Production site: Not specified SRI Consulting. 2007 Directory of Chemical Producers United States. Menlo Park, CA 2007, p. 699 from HSDB 8.8General Manufacturing Information HelpNew Window Industry Processing Sectors All other basic organic chemical manufacturing All other chemical product and preparation manufacturing Industrial cleaners/surfactants Miscellaneous manufacturing Pesticide, fertilizer, and other agricultural chemical manufacturing Soap, cleaning compound, and toilet preparation manufacturing from EPA Chemicals under the TSCA EPA TSCA Commercial Activity Status 1-Dodecanamine, N,N-dimethyl-, N-oxide: ACTIVE https://www.epa.gov/tsca-inventory from EPA Chemicals under the TSCA "AROMOX" /IS/ TRADEMARK FOR A SERIES OF METHYLATED OR ETHOXYLATED AMINE OXIDES DERIVED FROM HIGH-MOLECULAR-WT ALIPHATIC AMINES. USES: FOAM & SUDS STABILIZERS IN DETERGENT & COSMETIC FORMULATIONS; SURFACTANTS. /AROMOX/ Hawley, G.G. The Condensed Chemical Dictionary. 9th ed. New York: Van Nostrand Reinhold Co., 1977., p. 74 from HSDB 9Safety and Hazards HelpNew Window 9.1Hazards Identification HelpNew Window 9.1.1GHS Classification HelpNew Window Pictogram(s) Corrosive Irritant Environmental Hazard Signal Danger GHS Hazard Statements Aggregated GHS information provided by 835 companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 24 of 835 companies. For more detailed information, please visit ECHA C&L website Of the 26 notification(s) provided by 811 of 835 companies with hazard statement code(s): H302 (16.89%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (91.62%): Causes skin irritation [Warning Skin corrosion/irritation] H318 (78.18%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H319 (17.88%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H400 (64.24%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H412 (43.9%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. Precautionary Statement Codes Lauryl Amine Oxide P264, P270, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P332+P313, P337+P313, P362, P391, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) from European Chemicals Agency (ECHA) 9.1.2EPA Safer Chemical HelpNew Window Chemical: N,N-Dimethyldodecylamine oxide Green circle Green circle - The chemical has been verified to be of low concern based on experimental and modeled data. from EPA Safer Choice 9.1.3Health Hazard HelpNew Window Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016) U.S. Department of Transportation, Transport Canada, and Secretariat of Communications and Transport of Mexico, with collaboration from Argentina's Centro de Información Química para Emergencias. 2016 Emergency Response Guidebook. https://www.phmsa.dot.gov/hazmat/outreach-training/erg (accessed April 26, 2016). Lauryl Amine Oxide from CAMEO Chemicals

 

9.1.4Fire Hazard HelpNew Window Flash point data for this compound are not available. It is probably nonflammable. (NTP, 1992) National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. from CAMEO Chemicals Aid Measures HelpNew Window 9.2.1First Aid HelpNew Window EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.

 

 

from CAMEO Chemicals
9.3Fire Fighting HelpNew Window
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. from CAMEO Chemicals 9.4Accidental Release Measures HelpNew Window 9.4.1Isolation and Evacuation HelpNew Window Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016) U.S. Department of Transportation, Transport Canada, and Secretariat of Communications and Transport of Mexico, with collaboration from Argentina's Centro de Información Química para Emergencias. 2016 Emergency Response Guidebook. https://www.phmsa.dot.gov/hazmat/outreach-training/erg (accessed April 26, 2016). from CAMEO Chemicals 9.4.2Disposal Methods HelpNew Window SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations. from HSDB 9.5Handling and Storage HelpNew Window 9.5.1Nonfire Spill Response HelpNew Window SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and protect it from moisture. (NTP, 1992) National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. from CAMEO Chemicals 9.6Exposure Control and Personal Protection HelpNew Window 9.6.1Protective Equipment and Clothing HelpNew Window RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992) National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. from CAMEO Lauryl Amine Oxide Chemicals 9.7Stability and Reactivity HelpNew Window 9.7.1Air and Water Reactions HelpNew Window Hygroscopic (NTP, 1992). National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. from CAMEO Chemicals 9.7.2Reactive Group HelpNew Window Amines, Phosphines, and Pyridines Oxidizing Agents, Weak from CAMEO Chemicals

 

 

9.7.3Reactivity Profile HelpNew Window
DIMETHYLDODECYLAMINE-N-OXIDE is less basic than the tertiary amine from which it is derived, but still reacts with strong acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. from CAMEO Chemicals 9.8Transport Information HelpNew Window 9.8.1DOT Label HelpNew Window Poison from CAMEO Chemicals 9.9Other Safety Information HelpNew Window 9.9.1Special Reports HelpNew Window Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 231-45 (1994) from HSDB 10Toxicity HelpNew Window 10.1Toxicological Information HelpNew Window 10.1.1Acute Effects HelpNew Window 3 items Download Organism Test Type Route Dose Effect Reference rat LD50 intraperitoneal 271 mg/kg (271 mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX); BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY); BEHAVIORAL: ATAXIA National Technical Information Service., OTS0540973 mouse LD50 oral 2700 mg/kg (2700 mg/kg) French Medicament Patent Document., #4264M mouse LD50 intraperitoneal 375 mg/kg (375 mg/kg) French Medicament Patent Document., #4264M from ChemIDplus 10.1.2Non-Human Toxicity Excerpts HelpNew Window /LABORATORY ANIMALS: Acute Exposure/ The ocular irritation potential of formulations containing 0.3% active lauramine oxide was evaluated by instilling 10 uL into the conjunctival sac of New Zealand White rabbits. The eyes of some rabbits were rinsed with distilled water. Irritation was scored according to the method of Draize (maximum possible score: 110). Slight irritation of the conjunctivae was observed in all unrinsed eyes and in two of three rinsed eyes at the 24-hr grading period. The maximum average score was 2.0 for the animals with unrinsed eyes, and 1.3 for those whose eyes were rinsed. All eyes were clear after 48 hr. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 238 (1994) from HSDB /LABORATORY ANIMALS: Acute Exposure/ The primary dermal irritation potential of three formulations, each containing 30% lauramine oxide, was evaluated using New Zealand white rabbits. Three male and three female rabbits had 0.5 mL of each formulation applied under occlusive patches to separate sites on their clipped backs for 24 hr. The sites were rinsed after patch removal and were scored for erythema, eschar, and edema at the time of removal and 48 hr later. The primary dermal indices (maximum possible score: 8) were 7.0, 7.2, and 7.6. Moderate to severe erythema and edema, two cases of necrosis, and one case of necrosis and fissuring with bleeding were observed at the 24-hr grading period. At the 72-hr reading, ... severe erythema and edema, eschar, fissuring with bleeding, and necrosis and/or thickened skin /did occur/.
Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 238 (1994) from HSDB /LABORATORY ANIMALS: Acute Exposure/ Liquid droplet aerosol /formulation containing 0.3% active lauramine oxide/ at concentrations of 0.2, 1.0, and 5.2 mg/L were tested on three groups of four male Swiss-Webster mice. Only the heads of the mice were exposed to the aerosol. The average respiratory rate was monitored using plethysmography 5 min before, 10 min during, and 10 min after each exposure, and the percentage change in respiratory rate was calculated. A decrease in respiratory rate was considered a response to upper airway irritation. A transient decrease was observed in the respiratory rate of the 1.0 mg/L exposed group, but this was not considered significant because no signs of irritation were seen at greater exposure concentrations. The groups treated with 1.0 mg/L and 5.2 mg/L had a 6% decrease in their average respiratory rates. However, these decreases were not attributed to upper airway irritation because the respiratory rates were even lower during the postexposure recovery period. No decrease in respiratory rate was observed in the 0.2 mg/L exposed mice. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 237 (1994) from HSDB Lauryl Amine Oxide /LABORATORY ANIMALS: Acute Exposure/ The acute inhalation toxicity of a liquid droplet aerosol formulation containing 0.3% active lauramine oxide was evaluated. Five female and five male albino Sprague-Dawley-derived rats were exposed for 4 hr to this aerosol at a concentration of 5.3 mg/L. The Equivalent Aerodynamic Diameter of the aerosol was 3.6 um with a geometric standard deviation of 1.91. The animals were observed during the exposure and two times daily for 14 days, and body weights were recorded before exposure and on days 1, 3, 7, and 14 postexposure. At necropsy, the major organs in the abdominal and thoracic cavities were weighed and observed. No deaths occurred during the study and all the rats appeared normal. A slight drop in body weight was observed in the males on day 1, but weight was gained normally for the remainder of the study. The weight gain in the females was normal. The organ weights were all within the anticipated normal control ranges for both sexes. No exposure-related pharmacotoxic signs were evident in any of the organs. The 4-hr LD50 for this aerosol was greater than 5.3 mg/L nominal. Lauryl Amine Oxide Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 236-7 (1994) from HSDB /LABORATORY ANIMALS: Acute Exposure/ The /oral/ LD50 was >25.0 mL/kg and >10.0 g/kg for two formulations containing 0.3% active lauramine oxide. Groups of three female and three male albino Sprague-Dawley rats were used to evaluate each product. All animals survived to termination, and no significant clinical or pathologic abnormalities were observed. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 236 (1994) from HSDB /LABORATORY ANIMALS: Acute Exposure/ The estimated oral LD50 of a formulation containing lauramine oxide was determined using the up-down and limit test procedures. An undiluted formulation containing 0.3% active lauramine oxide was administered by gavage to six female CD Sprague-Dawley rats at doses of 20 g/kg or greater. All animals survived to termination. No adverse signs were observed. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 236 (1994) from HSDB /LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ New Zealand White rabbits were used to assess the cutaneous and systemic toxicity of a formulation containing 0.3% active lauramine oxide. The abraded skin of five female and five male rabbits was exposed to the formulation five times a week for 4 weeks. The dosage was 2 mL/kg/day. A control group of five female and five male rabbits was exposed to distilled water. All animals survived to termination. No significant differences in mean body weights, body weight changes, clinical observations, mean absolute organ weights, or organ-to-body weight ratio between the treated and control groups were observed. Lauramine oxide caused slight to moderate erythema in female rabbits, and both male and female rabbits had slight edema, atonia, and fissuring, and slight to moderate desquamation. Histologically, both groups had a high incidence of subacute inflammation in the treated skin. The lesions were described as "... minimal infiltrations of lymphocytes with a few neutrophils and plasma cells in the superficial dermis." Two cases of epidermal acanthosis, one case of crusting, and one case of superficial dermal hemorrhage were also observed. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 237 (1994) Lauryl Amine Oxide /LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Feeding studies /were conducted/ to determine the carcinogenicity of lauramine oxide and its nitrosated products. Two groups of 24 male and 24 female F344 rats were given drinking water supplemented with 0.1% lauramine oxide alone or with 0.1% lauramine oxide plus 0.2% sodium nitrite for 93 weeks. Positive control rats were given drinking water with 0.2% sodium nitrite, and untreated control rats were given unsupplemented water. There was no significant difference in survival between the treated and untreated groups of male rats. For the females, those treated with lauramine oxide alone died significantly earlier than those treated with nitrite alone or with lauramine oxide plus sodium nitrite. No other differences in survival were observed between the female groups. There was a significant increase in the incidence of hepatic neoplasms (hepatocellular carcinomas and neoplastic nodules) in the male rats receiving lauramine oxide and nitrite. No significant increase in hepatic neoplasms was observed in rats receiving lauramine oxide alone. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 239 (1994) from HSDB /LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Chronic feeding and dermal studies were conducted with commercial alkyldimethylamine oxides (ADAO) in rats and mice. Rats were dosed with 0.01, 0.1, or 0.2% w/v ADAO (on a 100% active basis) in their diet for 104 weeks. Mice were exposed to ADAO via a dermal application of 0.1 ml of an aqueous solution of ADAO at concentrations of 0.05, 0.13, or 0.26% w/v ADAO (on a 100% active basis) once daily three times per week for 104 weeks. No compound-related carcinogenic effects were observed in either chronic test. /Alkyldimethylamine oxides/ PMID:3905482 Cardin CW et al; Fundam Appl Toxicol 5: 869-78 (1985) from HSDB /GENOTOXICITY/ An in vitro cell transformation assay was used to assess the carcinogenic potential of lauramine oxide. Cryopreserved primary cultures of Syrian golden hamster embryo cells were used as the source of target and feeder cells. Lauramine oxide, at doses of 0.1, 1, 5, 10, and 20 ug/mL, did not cause transformation. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 239 (1994) from HSDB /GENOTOXICITY/ Lauramine oxide and N-nitrosomethyl-n-dodecylamine /formed when lauramine is reacted with excess sodium nitrate/ were evaluated for mutagenicity using modified Ames test methods with S. typhimurium strains TA98 and TA100. Lauramine oxide, at doses ranging from 10 to 200 ug/plate, was not mutagenic with or without S9 activation. However, N-nitrosomethyl-n-dodecylamine, tested at doses ranging from 50 to 5,000 ug/plate, caused significant but low mutagenic activity in TA100 after metabolic activation.

 

Lauryl Amine Oxide Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 239 (1994) /GENOTOXICITY/ Lauramine oxide and its nitrosation products were tested for mutagenicity ... using the Ames test. Modifications of the Ames test were 0.2 mL of the tester strain instead of 0.1 mL, 20 mL of the /Vogel-Bonner Medium E/ (VBE) medium instead of 30 mL, and the Aroclor 1254-stimulated microsome S9 mix was used at a level of 75 uL of S9 fraction/test. Assays were conducted using lauramine oxide (250 kg) alone and lauramine oxide reacted with nitrite in an acid solution (to simulate nitrosation reactions that may occur in the stomach). Test strains of Salmonella typhimurium used were TA 1535, TA 1538, TA 98, and TA 100. Each test was conducted both with and without metabolic activation by S9 liver microsome fractions. Lauramine oxide alone was not mutagenic, either with or without activation. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 239 (1994) from HSDB 10.1.3Non-Human Toxicity Values HelpNew Window LD50 Rat (female CD Sprague-Dawley) oral >20 g/kg /Undiluted formulation containing 0.3% active lauramine oxide/ Lauryl Amine Oxide Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 236 (1994)

 

10.2Ecological Information HelpNew Window
10.2.1Environmental Fate/Exposure Summary HelpNew Window
Lauramine oxide's production and use as a surfactant in dishwasher detergent, shampoo and soap, as a foam stabilizer, and textile antistatic agent may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 6.2X10-8 mm Hg at 25 °C indicates lauramine oxide will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase lauramine oxide will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 14.1 hours. Particulate-phase lauramine oxide will be removed from the atmosphere by wet or dry deposition. Lauramine oxide does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, lauramine oxide is expected to have very high mobility based upon an estimated Koc of 5.5. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 6.6X10-11 atm-cu m/mole. In aqueous biodegradation screening tests, Lauryl Amine Oxide was 100% removed after 28 days as measured by liquid chromatography-mass spectrometry, suggesting that biodegradation in soil and water is an important fate process. If released into water, lauramine oxide is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 0.7 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to lauramine oxide may occur through dermal contact with this compound at workplaces where it is produced or used. The general population may be exposed to lauramine oxide via dermal contact with this compound in consumer products containing lauramine oxide. (SRC)

 

 

10.2.2Artificial Pollution Sources HelpNew Window
Lauramine oxide's production and use as a surfactant in dishwasher detergent, shampoo and soap(1), as a foam stabilizer, and textile antistatic agent(2) may result in its release to the environment through various waste streams(SRC). (1) Kosswig K; Ullmann's Encyclopedia of Industrial Chemistry. 7th ed. (2008). NY, NY: John Wiley & Sons; Surfactants. Online Posting Date: June 15, 2000. (2) Ashford RD; Ashford's Dictionary of Industrial Chemicals: Properties, Production Lauryl Amine Oxide, Uses. London, England: Wavelength Publ, Ltd. p. 331 (1994)

 

 

10.2.3Environmental Fate HelpNew Window
TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 5.5(SRC), determined from a water solubility of 190,000 mg/L(2) and a regression-derived equation(3), indicates that lauramine oxide is expected to have very high mobility in soil(SRC). Volatilization of lauramine oxide from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6.6X10-11 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Lauramine oxide is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 6.2X10-8 mm Hg(SRC), determined from a fragment constant method(5). In aqueous biodegradation screening tests, lauramine oxide was 100% removed after 28 days as measured by liquid chromatography-mass spectrometry(6), suggesting that biodegradation in soil is an important fate process(SRC).
(1) Swann RL et al; Res Rev 85: 17-28 (1983) (2) Brown SL et al.; Research Program on Hazard Priority Ranking of Manufactured Chemicals (Chemicals 61-79). NTIS PB-263 164. Menlo Park, CA: Stanford Research Institute (1975) (3) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-5 (1990) (4) Meylan WM, Howard PH; Environ Toxicol Chem 10: 1283-93 (1991) (5) Lyman WJ; p. 31 in Environmental Exposure From Chemicals Vol I, Neely WB, Blau GE, eds, Boca Raton, FL: CRC Press (1985) (6) NITE; Chemical Risk Information Platform (CHRIP). Biodegradation and Bioconcentration. Tokyo, Japan: Natl Inst Tech Eval. Available at http://www.safe.nite.go.jp/english/db.html as of June 17, 2008.

 

 

from HSDB
AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 5.5(SRC), determined from a water solubility of 190,000 mg/L(2) and a regression-derived equation(3), indicates that lauramine oxide is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 6.6X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 0.7(SRC), from its water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). In aqueous biodegradation screening tests, lauramine oxide was 100% removed after 28 days as measured by liquid chromatography-mass spectrometry(6), suggesting that biodegradation in water is an important fate process(SRC).
(1) Swann RL et al; Res Rev 85: 17-28 (1983) (2) Brown SL et al.; Research Program on Hazard Priority Ranking of Manufactured Chemicals (Chemicals 61-79). NTIS PB-263 164. Menlo Park, CA: Stanford Research Institute (1975) (3) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-5, 15-1 to 15-29, 5-5 (1990) (4) Meylan WM, Howard PH; Environ Toxicol Chem 10: 1283-93 (1991)(5) Franke C et al; Chemosphere 29: 1501-14 (1994) (6) NITE; Chemical Risk Information Platform (CHRIP). Biodegradation and Bioconcentration. Tokyo, Japan: Natl Inst Tech Eval. Available at http://www.safe.nite.go.jp/english/db.html as of June 17, 2008.

 

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), lauramine oxide, which has an estimated vapor pressure of 6.2X10-8 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase Lauryl amine oxide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 14.1 hours(SRC), calculated from its rate constant of 2.7X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3) Particulate-phase Lauryl amine oxidee may be removed from the air by wet or dry deposition(SRC). Lauramine oxide does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

 

10.2.4Environmental Biodegradation HelpNew Window
AEROBIC: Lauryl amine oxide, present at 100 mg/L, was 100% removed in 4 weeks as measured by liquid chromatography-mass spectrometry, using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). An inherent biodegradability test using an activated sludge inoculum at 100 mg/L and Lauryl amine oxide at 30 mg/L showed the compound to reach 88% of its theoretical total organic carbon in 4 weeks(1).

 

 

10.2.5Environmental Abiotic Degradation HelpNew Window
The rate constant for the vapor-phase reaction of lauryl amine oxide with photochemically-produced hydroxyl radicals has been estimated as 2.7X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 14.1 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Lauryl amine oxide is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Lauryl amine oxide does not contain chromophores that absorb at wavelengths >290 nm(2) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).
from HSDB
10.2.6Environmental Bioconcentration HelpNew Window An estimated BCF of 0.7 was calculated for lauramine oxide(SRC), using a water solubility of 190,000 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). (1) Brown SL et al; Research Program on Hazard Priority Ranking of Manufactured Chemicals (Chemicals 61-79). NTIS PB-263 164. Menlo Park, CA: Stanford Research Institute (1975) (2) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 5-5 (1990) (3) Franke C et al; Chemosphere 29: 1501-14 (1994) from HSDB Lauryl amine oxide 10.2.7Soil Adsorption/Mobility HelpNew Window The Koc of lauramine oxide is estimated as 5.5(SRC), using a water solubility of 190,000 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that lauramine oxide is expected to have very high mobility in soil. (1) Brown SL et al; Research Program on Hazard Priority Ranking of Manufactured Chemicals (Chemicals 61-79). NTIS PB-263 164. Menlo Park, CA: Stanford Research Institute (1975) (2) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-5 (1990) (3) Swann RL et al; Res Rev 85: 17-28 (1983) from HSDB 10.2.8Volatilization from Water/Soil HelpNew Window The Henry's Law constant for lauramine oxide is estimated as 6.6X10-11 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that lauramine oxide is expected to be essentially nonvolatile from water surfaces(2). Lauramine oxide's Henry's Law constant indicates that volatilization from moist soil surfaces is not likely to occur(SRC). Lauramine oxide is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 6.2X10-8 mm Hg(SRC), determined from a fragment constant method(3). (1) Meylan WM, Howard PH; Environ Toxicol Chem 10: 1283-93 (1991) (2) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 15-1 to 15-29 (1990) (3) Lyman WJ; p. 31 in Environmental Exposure From Chemicals Vol I, Neely WB, Blau GE, eds, Boca Raton, FL: CRC Press (1985) from HSDB 10.2.9Probable Routes of Human Exposure HelpNew Window NIOSH (NOES Survey 1981-1983) has statistically estimated that 91,001 workers (38,251 of these were female) were potentially exposed to lauramine oxide in the US(1). Occupational exposure may occur through dermal contact with this compound at workplaces where lauramine oxide is produced or used. The general population may be exposed to lauramine oxide via dermal contact with this compound and consumer products containing lauramine oxide(SRC). (1) NIOSH; NOES. National Occupational Exposure Survey conducted from 1981-1983. Estimated numbers of employees potentially exposed to specific agents by 2-digit standard industrial classification (SIC). Available at http://www.cdc.gov/noes/ as of June 17, 2008. (2) Kosswig K; Ullmann's Encyclopedia of Industrial Chemistry. 7th ed. (2008). NY, NY: John Wiley & Sons; Surfactants. Online Posting Date: June 15, 2000.
Suppliers:
Acme-Hardesty
Lauryl Amine Oxide
Odor: characteristic
Use: Chemical Intermediate, Nonionic Surfactant and Foaming Stabilizer in Soaps and Detergents.
Alzo International
Foamox DML
BOC Sciences
For experimental / research use only.
N,N-Dimethyldodecylamine N-oxide
Carbosynth
For experimental / research use only.
N,N-Dimethyldodecylamine N-oxide
Galaxy Surfactants North America
Lauryl Dimethylamine Oxide
Odor: characteristic
Use: SURFOX LO-SPECIAL is a light-colored amine oxide that provides excellent foam boosting and stability. It is compatible with most surfactants and because there are no amide or ester groups, SURFOX LO-SPECIAL will not hydrolyze in acid systems. It is also stable in sodium hypochlorite and in highly alkaline products. Graham Chemical Lauramine Oxide (Performer Amine Oxide G702) Kao Corporation AMPHITOL 20N Odor: characteristic Use: for liquid detergents increasing foam ability high detergency. Prevent skin roughness Kao Corporation OXIDET DM-20 Odor: characteristic Use: Thickening effect. pH influence on viscosity . Cationic character at low pH. Perfume solubilizer and thickener in hypochlorite solutions. Lubrizol Corporation LO-PF Surfactant Odor: characteristic Use: ChemoxideTM LO-PF is a bleach stable, low odor Amine Oxide. It exhibits good tolerance to electrolytes which permits improved performance in hard water. Foaming properties are stable within a pH range of 5-12. Chemoxide LO-PF provides good viscosity response and foam enhancement for personal care products such as shampoos and shower gels. Chemoxide LO-PF is a nonionic surfactant which is compatible with anionic and cationic systems.Because of its foam boosting and viscosity building properties, Chemoxide LO-PF is useful in a variety of cosmetic products. Replacement of the nonionic surfactants commonly used in skin and hair cleansing product formulations can give better, more stable foaming properties. Lubrizol Corporation SchercamoxTM DML Amine Oxide Odor: characteristic Use: SchercamoxTM DML amine oxide finds numerous applications as an emulsifier, emulsion stabilizer, anti-static agent and more. In shampoo formulations, Schercamox DML amine oxide is used as a foam booster and thickener, and can be used in conjunction with or instead of alkanolamides. In neutral or alkaline solutions, Schercamox DML amine oxide exhibits a nonionic character, and is therefore compatible with anionics. In acid solutions, it exhibits mild quaternary properties which enable it to impart substantivity on skin and hair. Noble Molecular Research For experimental / research use only. N,N-Dimethyl-1-dodecylamine N-oxide Santa Cruz Biotechnology For experimental / research use only. N,N-Dimethyldodecylamine N-oxide ≥94% sds Sigma-Aldrich: Sigma For experimental / research use only. N,N-Dimethyldodecylamine N-oxide ≥99% (titration) Lauryl amine oxide sds Stepan Company AMMONYX® LO SPECIAL sds Stepan Company AMMONYX® LO sds Stepan Company AMMONYX® M Universal Preserv-A-Chem Inc. LAURAMINE OXIDE Odor: characteristic Use: Amine oxides are surfactants commonly used in consumer products such as shampoos, conditioners, detergents, and hard surface cleaners. WholeChem Lauramine oxide (aka Ammonyx LO)

 

 

Safety in Use Information:
Category: emulsifiers and foaming agents Recommendation for lauramine oxide usage levels up to: not for fragrance use. Recommendation for lauramine oxide flavor usage levels up to: not for flavor use. Safety References: European Food Safety Authority (EFSA) reference(s): Flavouring Group Evaluation 45 (FGE.45)[1]: One tertiary amine from chemical group 28 View page or View pdf EPI System: View Daily Med:search Lauryl Amine Oxide Hazardous Substances Data Bank:Search Cancer Citations:Search Toxicology Citations:Search Carcinogenic Potency Database:Search Env. Mutagen Info. Center:Search EPA Substance Registry Services (TSCA):1643-20-5 EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :15433 National Institute of Allergy and Infectious Diseases:Data WISER:UN 3259 WGK Germany:2 N,N-dimethyldodecan-1-amine oxide Chemidplus:0001643205 EPA/NOAA CAMEO:hazardous materials RTECS:JR6650000 for cas# 1643-20-5
Product Performance
Vicamox 405 is a water-based nonionic or amphoteric surfactant of the amine oxide type. When formulated with acids, the amine oxide can behave as a cationic surfactant but in neutral or alkaline conditions, it will behave as a nonionic surfactant. Lauryl amine oxide usage Useful as a foam booster and detergent in the following formulations or applications:- Dish washing detergents Laundry detergents All-purpose cleaning agents Liquid bleach products (as the surfactant) Shampoos Bubble baths Hair conditioners Foam stabilizer for rubber and polymer industries Key Points Readily biodegradable means that it will have a low environmental impact. Generally produces a rich stable foam. Good compatibility profile means that it can be used in a wide variety of products Evaluation and Testing pH (neat) 8.0 Amine Oxide 30% Colour 1 Gardner SG (20ºC) 0.97 Free Peroxide <0.1% Storage and Safety STORAGE When stored indoors at temperatures below 40ºC and in closed original containers, this product can be stored for at least 1 year. Refer to MSDS at www.vicchem.com for further information

 

 

HEALTH, SAFETY & ENVIRONMENT
VICAMOX 405 is a biodegradable surfactant which is not classified as a dangerous good. According to experience this product is considered to be safe if used in the correct manner. Skin and eye contact should be avoided. Refer to MSDS at www.vicchem.com Lauryl Amine Oxide Nitroxides are stable cyclic radicals, differing in size, charge, and lipophilicity (and therefore permeability through biological membranes).22-24 Their use as biophysical probes or contrast agents for nuclear magnetic resonance imaging has been investigated extensively and reviewed.25 rom: Methods in Enzymology, 2004 Related terms: Nucleic AcidCarnitineSurfactantsAmine OxidesTrimethylglycineTetrahydrofuransAminesIctalCellulase View all Topics Download as PDF Set alert About this page Learn more about Amine Oxide FISH | Important Elasmobranch Species J.P.H Wessels, in Encyclopedia of Food Sciences and Nutrition (Second Edition), 2003 Ammonia Formation While ammonia production owing to bacterial action is a common feature of fish flesh, the effect is exaggerated in the flesh of cartilaginous fishes. These fish possess, in addition to the trimethyl amine oxide of fish blood and muscle, a further nitrogen-rich compound, urea (carbonyl amide), which functions in osmoregulation to maintain the fish in balance with its salt-water environment. Bacteria that come in contact with the blood or flesh of the fish after death break down these compounds to release amines and, in the case of urea, ammonia with its characteristic pungent ‘fishy' smell; the release of ammonia is a first step in the breakdown process, resulting from bacterial urease activity. (See AMINES.)
Dominguez et al. [164] showed that mixtures of cocamidopropyl betaine and SLS elicited less ocular irritation than did either surfactant alone. They ascribed this synergism to interactions between the surfactants in solution, reducing the amount of either species available to elicit irritation. This could also explain the effect seen in Table C.3.8 with lauryl dimethyl amine oxide, lauryl amine oxide i.e. a cationically charged surfactant interacts or associates strongly with the anionic surfactant, reducing the amount of either species available to cause irritation. Similarly, Faucher and Goddard [138] demonstrated a reduction in SLS adsorption to human hair keratin when a nonionic surfactant, Tergitol 15-S-9 (which is a 15-carbon alcohol containing 9 ethoxylate units), was added to the system, even though the total concentration of the surfactant in the system increased with the added nonionic surfactant. As very little nonionic surfactant was adsorbed to the hair, the authors suggest that the Tergitol and SLS are interacting in solution, preventing SLS binding. Inclusion of the nonionic in the system will lower the CMC, thus reducing the amount of free SLS monomer available to interact with skin (see section on role of CMC).

 

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