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DIMETHYL AMINO ETHANOL (DMAE)

DIMETHYL AMINO ETHANOL (DMEAE) ;


CAS NUMBER; 108-01-0

 

EC NUMBER; 203-542-8


SYNONYMS; 2-Aminoethanol, 2-Aminoethyl alcohol, ETA, MEA 90, MEA-LCI, MEA, Monoethanolamine; N,N-Dimethyl-2-hydroxyethylamine, N,N-Dimethylethanolamine, DMEA, Jeffcat DMEA; MFCD00002846; 24870734; 2-(Dimethylamino)-ethanol for synthesis. CAS 108-01-0, chemical formula (CH₃)₂NCH₂CH₂OH.; N,N-Dimethylethanolamine; N,N Dimethylethanolamine; 2-(Dimethylamino)-ethanol; SCHEMBL9291503; MTLRKYIFXXCOBF-UHFFFAOYSA-N; 1-(DIMETHYLAMINO)ETHANOL;PROPAN-2-OL; InChI=1S/C4H11NO.C3H8O/c1-4(6)5(2)3;1-3(2)4/h4,6H,1-3H3;3-4H,1-2H3; MTLRKYIFXXCOBF-UHFFFAOYSA-N; dimethylamino-ethanol; DI-METHYLAMINOETHANOL; CTK6H9359; MDLKWDQMIZRIBY-UHFFFAOYSA-N; 21507-EP2295438A1; 21507-EP2314295A1; 21507-EP2314590A1; 106383-EP2287165A2; 106383-EP2287166A2; 106383-EP2292620A2; 106383-EP2295436A1; 106383-EP2298773A1; 106383-EP2371809A1; 108-01-0 [RN]; 1209235 [Beilstein]; 2-(Dimethylamino)-1-ethanol; 2-(Dimethylamino)ethanol [ACD/IUPAC Name]; 2-(Dimethylamino)ethanol [German] [ACD/IUPAC Name]; 2-(Diméthylamino)éthanol [French] [ACD/IUPAC Name]; 203-542-8 [EINECS]; 2-Dwumetyloaminoetanolu [Polish]; 2N6K9DRA24; 4-11-00-00122 [Beilstein]; Deanol [Wiki]
Dimethyl(2-hydroxyethyl)amine; Dimethyl(hydroxyethyl)amine; Dimethylaethanolamin [German]; Dimethylaminoaethanol [German]; DMAE; Ethanol, 2-(dimethylamino)- [ACD/Index Name]; MFCD00002846 [MDL number]; N-(2-Hydroxyethyl)dimethylamine; N,N-Dimethyl-2-aminoethanol; N,N-Dimethyl-2-hydroxyethylamine; N,N-Dimethylethanolamine; N,N-Dimethyl-N-(2-hydroxyethyl)amine; N,N-Dimethyl-N-(β-hydroxyethyl)amine; UNII-2N6K9DRA24; β-Dimethylaminoethyl alcohol; β-Hydroxyethyldimethylamine; (2-Hydroxyethyl)dimethylamine; (CH3)2NCH2CH2OH; (Dimethylamino)ethanol; 116134-09-9 alternate RN [RN]; 2-(Dimethylamino) ethanol; 2-(dimethylamino)ethan-1-ol; 2-(Dimethylamino)-ethanol; 2-(N,N-Dimethylamino)ethanol; 2-Dimethylamino ethanol; 2-Dimethylamino-ethanol; 2-DIMETHYLAMINOETHANOL; Amietol M 21 [Trade name]; Bimanol [Trade name]; Demanol [Trade name]; Dimethylaminoethanol [Wiki]; Dimethylethanoiamine; Dimethylethanolamine [Wiki]; Dimethylmonoethanolamine; DMEA; Kalpur P [Trade name]; Liparon [Trade name]; N-(Dimethylamino)ethanol; N,N-Dimethyl ethanolamine; N,N-Dimethyl(2-hydroxyethyl)amine; N,N-dimethylaminoethanol; N,N'-Dimethylethanolamine; N,N-Dimethyl-N-(β -hydroxyethyl)amine; N,N-Dimethyl-N-(β-hydroxyethyl)amine; N,N-Dimethyl-N-ethanolamine; N,N-Dimethyl-N-ethanolamine.N,N-Dimethyl-β -hydroxyethylamine; N,N-Dimethyl-β-hydroxyethylamine; N-Benzyloxycarbonyl-L-tyrosine; N-dimethyl aminoethanol; N-Dimethylaminoethanol; Norcholine [Trade name]; Propamine A [Trade name]; Q2N1 & 1 [WLN]; Texacat DME [Trade name]; UN 2051; Varesal [Trade name]; β -(dimethylamino)ethanol; β -(dimethylamino)ethyl alcoholβ -dimethylaminoethyl alcohol; β -hydroxyethyldimethylamine; β-(Dimethylamino)ethanol; β-(Dimethylamino)ethyl alcohol; β-Dimethylaminoethyl alcohol; β-Hydroxyethyldimethylamine ; 13854944; DMAE;DEANOL;Bimanol;kalpurp;Liparon;Varesal;Panclar;FC DMEA;Kalpur p;Dabco DMEA; (1) 2-(DIMETHYLAMINO)ETHANOL; (1) 2-(dimethylamino)ethanol: dimethylethanol amine; (2) 1-dimethylamino-2-propanol: dimethylisopropanolamine; 2-dimethylaminoethanol; deanol; dimethylethanolamine; (dimethylamino)ethanol; N,N-dimethylaminoethanol; N,N-dimethyl-2-hydroxyethylamine; N,N-dimethylethanolamine; N,N-dimethyl-.beta.-hydroxyethylamine; N,N-dimethyl-2-aminoethanol; N,N-dimethyl-N-(.beta.-hydroxyethyl)amine; N-(2-hydroxyethyl)dimethylamine; .beta.-(dimethylamino)ethanol; .beta.-dimethylaminoethyl alcohol; (N,N-dimethylamino)ethanol; 2-(dimethylamino)ethyl alcohol; .beta.-hydroxyethyldimethylamine; (2-hydroxyethyl)dimethylamine; dimethylmonoethanolamine; dimethyl(hydroxyethyl)amine; dimethyl(2-hydroxyethyl)amine; ethanolamine, N,N-dimethyl-; ethanol, 2-(dimethylamino)-; (2-Hydroxyethyl)dimethylamin; 2-(dimethylamino)-1-Ethanol 2-(N,N-dimethylamino)Ethanol ; 2-Dimethylaminoethanol; beta-Dimethylaminoethyl alcohol ; beta-Hydroxyethyldimethylamine; Dimethyl(2-hydroxyethyl)amine; Dimethyl(hydroxyethyl)amine; Dimethylaminoaethanol; Dimethylaethanolamin; Dimethylethanolamine; ; DimethylmonoethanolaminE; DMAE; DMEA; N,N-Dimethyl-2-aminoethanol; N,N-Dimethyl-2-hydroxyethylamine; N,N-Dimethyl-N-(2-hydroxyethyl)amine; N,N-Dimethyl-N-(beta-hydroxyethyl)amine; N,N-Dimethylaminoethanol; N-(2-Hydroxyethyl)dimethylamine; N-Dimethylaminoethanol; NorcholinE Propamine a ; b-Dimethylaminoethyl alcohol; β-dimethylaminoethyl alcohol; b-Hydroxyethyldimethylamine; β-hydroxyethyldimethylamine; N,N-Dimethyl-N-(b-hydroxyethyl)amine; N,N-Dimethyl-N-(β-hydroxyethyl)amine; (CH3)2nch2ch2oh; (dimethylamino)Ethanol ; 2-(dimethylamino) Ethanol; 2(dimethylamino)-Ethanol ; 2-(dimethylamino)Ethanol; 2-Dimethylamino; 2-dimethylamino-Ethanol; 2-Dwumetyloaminoetanolu; Amietol m 21; beta -(dimethylamino)Ethanol; beta -(dimethylamino)Ethyl alcohol; beta -Dimethylaminoethyl alcohol; beta -Hydroxyethyldimethylamine; Bimanol; dabco Dmea; Demanol; Demanyl; Dimethylaminoethanol; Dimethylethanoiamine; Kalpur P; Liparon; N, N-Dimethyl(2-hydroxyethyl)amine; N, N-Dimethyl-N-(2-hydroxyethyl)amine; N, N-Dimethyl-N-(beta -hydroxyethyl)amine; N,N'-dimethylethanolamine; N,N-Dimethyl(2-hydroxyethyl)amine; N,N-Dimethyl-beta -hydroxyethylamine; N,N-Dimethyl-N-(beta -hydroxyethyl)amine ; N,N-Dimethyl-N-ethanolamine; N,N-Dimethylaminoethanol (dmae); N,N-Dimethylethanolamine; N-(dimethylamino)Ethanol; N-Benzyloxycarbonyl-L-tyrosine; N-CBZ-L-Tyrosine; Phosphatidyl-N; dimethylethanolamine; Tegoamin dmea; Texacat dme; Tonibral; Toyocat -dma; Varesal; UEEJHVSXFDXPFK-UHFFFAOYSA-N; Dimethylethanolamine; 2-(DIMETHYLAMINO)ETHANOL; N,N-DIMETHYLETHANOLAMINE (DMEA); 2-(Dimethylamino) EthanoL; Dimethyl Amino Ethanol; Dimethylamino ethanol; (Dimethylamino)ethanol; 2-(Dimethylamino)ethanol; 2-(Dimethylamino)ethanol N-oxide; Dimethyl Amino Ethanol; Guinea pig ileumDimethylaminopropanolDimethylaminoethaneDirect and indirect cholinomimetic activityDimethylaminoethanolCholine; Guinea pig ileumDimethylaminopropanolDimethylaminoethaneDirect and indirect cholinomimetic activityDimethylaminoethanolCholine; 2-((2-(Dimethylamino)ethyl)(methyl)amino)ethanol; 2-((2-(Dimethylamino)ethyl)(methyl)amino)ethanol; (2-Hydroxyethyl)dimethylamine; (Dimethylamino)ethanol; (N,N-Dimethylamino)ethanol; 2-(Dimethylamino)ethanol; 2-(Dimethylamino)ethyl alcohol; 2-(N,N-Dimethylamino)ethanol; 2-Dimethylaminoethanol; 2-dimetilaminoetanol; Amietol M 21; Aminoalcohol 2mabs; Bimanol; Dabco DMEA; Deanol; Dimethol; Dimethyl(2-hydroxyethyl)amine; Dimethyl(hydroxyethyl)amine; DIMETHYLAMINOETHANOL; Dimethylaminoethanol, 2-; DIMETHYLETHANOLAMINE; Dimethylmonoethanolamine; DMAE; DMEA; Ethanol, 2-(dimethylamino)-; ETHANOLAMINE, N,N-DIMETHYL-; Jeffcat DMEA; Kalpur P; Lupragen N 101; N-(2-Hydroxyethyl)dimethylamine; N-(2-Hydroxyethyl)-N,N-dimethylamine; N,N-Dimethyl(2-hydroxyethyl)amine; N,N-Dimethyl-2-aminoethanol; N,N-DIMETHYLAETHANOLAMIN; N,N-DIMETHYLAMINO ETHANOL; N,N-Dimethylethanolamine; N,N-Dimethyl-N-(β-hydroxyethyl)amine; N,N-Dimethyl-β-hydroxyethylamine; Niax DMEA; Norcholine; NSC 2652; PC CAT DMEA
Propamine A; Rexolin; Tegoamin DMEA; Texacat DME; Texacat DMEA; Thancat DME; UN 2051; UN 2051; β-(Dimethylamino)ethanol; β-Dimethylaminoethyl alcohol; β-Hydroxyethyldimethylamine; deacidification, extraction, amines, triacylglycerols, 2-dimethylamino-ethanol (DMAE); 2-(Dimethylamino)ethanol; 2-([2-(Dimethylamino)ethyl]methylamino)ethanol; Ethanol, 2-[[2-(dimethylamino)ethyl]methylamino]-;LUPRAGEN(R) N 400; 2-[[2-(dimethylamino)ethyl]methylamino]etanol; 2-[[2-(DIMETHYLAMINO)ETHYL]METHYLAMINO]ETHANOL; N,N,N'-TRIMETHYLAMINOETHYLETHANOLAMINE; N-Methyl-N-(N,N-dimethylaminoethyl)-aminoethanol; 2-[[2-(dimethylamino)ethyl]methylamino]-ethano; Ethanol, 2-[[2-(dimethylamino)ethyl]methylamino]-; Ethanol,2-[[2-(dimethylamino)ethyl]methylamino]-;N-Methyl-N-(N,N-dimethylaminoethyl)-aminoethanol; 2-((2-(Dimethylamino)Ethyl)(Methyl)Amino)Ethanol; InChI=1S/C11H15N3O/c1-8-3-4-10-9(7-8)13-11(14(10)2)12-5-6-15/h3-4,7,15H,5-6H2,1-2H3,(H,12,13); DİMETHYL AMİNO ETHANOL; DIMETHYL AMINO ETHANOL; DİMETİL AMİNO ETHANOL; Dİ METİL AMİNO ETANOL; DI METIL AMINO ETANOL; dimetyl amino ethanol; dımethyl amıno ethanol ; di metil amino etanol; dietil amino etanol; di metyl amıno ethanol; dimetil amino ethanol; di methyl amino ethanol; di metil amino etanol; dimetil amino etanol; dımetıl amıno etanol; dı metıl amıno etanol; dı metıl amıno ethanol;

 

 


PHYSICAL PROPERTIES
Structural formula (CH3)2 N-CH2-CH2-OH
Molecular Wt. 89.14
Specific Gravity at 20/20 °C 0.8883
Refractive Index 1.4294
Boiling Point 134.6 °C
Freezing Point -58.6 °C
Solubility in Water Soluble
Flash Point 39.4 °C
Vapor Pessure(mm hg) 4.4 @ 20 °C
Vapor Density 3.1
Odor Ammoniacal Odor


Abstract

Dimethylaminoethanol (DMAE) and dimethylaminopropanol (DMAP) possess indirect cholinomimetic activity in the isolated guinea pig ileum preparation. This activity does not involve the stimulation of nicotinic receptors. Their ability to release acetylcholine was indicated by lack of stimulant activity in tissues pretreated with morphine or tetrodotoxin and in cooled tissues, and was confirmed by assay of released acetylcholine. The closely related cholinomimetic compounds choline and dimethylaminoethane (DME) acted predominantly through muscarinic and nicotinic receptor stimulation respectively. Isoamylalcohol was devoid of stimulant activity. Indirect cholinomimetic activity appears to be dependent on the presence of a tertiary nitrogen group (as in DMAE, DMAP and DME). The absence of an hydroxyl group results in direct stimulation of nicotinic receptors (DME) while in the presence of an hydroxyl group (DMAE, DMAP), acetylcholine release is ‘aganglionic'. Quaternisation of the nitrogen (choline) results in direct stimulant actions on post-junctional cholinergic receptor sites.

What is DMAE?

DMAE is a naturally occurring chemical, produced by the brain, that functions as an anti-oxidant. As such, it can strengthen the body's ability to fight environmental stressors such as airborne chemicals. As a dietary supplement, it can enhance brain function, strengthen the immune system, help the body to deal with dietary stressors such as hydrogenated fats, and even reduce the severity of hangovers. Studies have shown that DMAE can be more effective than some other antioxidants because it moves from the blood to the brain more easily.

What are the health benefits of DMAE?

The most popular use of DMAE is skincare. It helps to slow the development of some aspects of the aging process, such as liver spots and facial sagging. It has also been found to be useful in the treatment of mood disorders such as depression and ADHD (Attention Deficit Hyper-Activity Disorder), and in therapy for traumatic brain injuries.

 

FİZİKİ OZELLİKLERİ
Yapısal formül (CH3) 2 N-CH2-CH2-OH
Moleküler Wt. 89,14
20/20 ° C'deki Özgül Ağırlık 0.8883
Kırılma İndeksi 1.4294
Kaynama noktası 134.6 ° C
Donma Noktası -58.6 ° C
Suda Çözünebilirlik Çözünürlüğü
Parlama noktası 39.4 ° C
Buhar Pessürü (mm hg) 4.4 @ 20 ° C
Buhar yoğunluğu 3.1
Koku Amonyak Koku


Açıklama

Dimetilaminoetanol (DMAE) ve dimetilaminopropanol (DMAP), izole edilmiş guinea domuz ileum preparasyonunda dolaylı kolinomimetik aktiviteye sahiptir. Bu aktivite, nikotinik reseptörlerin uyarılmasını içermez. Asetilkolin salma kabiliyetleri, morfin veya tetrodotoksin ile ön-muamele edilmiş ve soğutulmuş dokularda uyarılmış dokulardaki uyarıcı aktivitesinin eksikliği ile belirtilmiş ve serbest asetilkolinin analizi ile doğrulanmıştır. Yakın ilişkili kolinomimetik bileşikler kolin ve dimetilaminoetan (DME), sırasıyla muskarinik ve nikotinik reseptör stimülasyonu yoluyla etkili olmuştur. İzoamilalkol, uyarıcı aktivitesinden yoksundu. Dolaylı kolinomimetik aktivitenin bir tersiyer nitrojen grubunun varlığına bağlı olduğu görülmektedir (DMAE, DMAP ve DME'de olduğu gibi). Bir hidroksil grubunun yokluğu, bir hidroksil grubu (DMAE, DMAP) varlığında, asetilkolin salımı "aganglionik" olduğunda, nikotinik reseptörlerin (DME) doğrudan uyarılması ile sonuçlanır. Nitrojenin (kolin) kuaternizasyonu, birleşme sonrası kolinerjik reseptör bölgelerinde doğrudan uyarıcı etkilere yol açar.


DMAE nedir?

DMAE, beyin tarafından üretilen ve bir antioksidan olarak işlev gören doğal olarak oluşan bir kimyasaldır. Bu nedenle, vücudun havadaki kimyasallar gibi çevresel streslerle savaşma kabiliyetini güçlendirebilir. Bir diyet takviyesi olarak, beyin fonksiyonunu güçlendirebilir, bağışıklık sistemini güçlendirebilir, vücudun hidrojene yağlar gibi diyet stresleri ile başa çıkmasına yardımcı olabilir ve hatta hangoverslerin şiddetini azaltabilir. Çalışmalar DMAE'nin diğer bazı antioksidanlardan daha etkili olabileceğini göstermiştir çünkü kandan beyne daha kolay hareket eder.

DMAE'nin sağlık faydaları nelerdir?

DMAE'nin en popüler kullanımı cilt bakımıdır. Karaciğer lekeleri ve yüz sarkması gibi yaşlanma sürecinin bazı yönlerinin gelişimini yavaşlatmaya yardımcı olur. Ayrıca depresyon ve DEHB (Dikkat Eksikliği Hiper-Aktivite Bozukluğu) gibi duygudurum bozukluklarının tedavisinde ve travmatik beyin yaralanmaları tedavisinde de yararlı olduğu bulunmuştur.

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